{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T03:06:17Z","timestamp":1778123177001,"version":"3.51.4"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T00:00:00Z","timestamp":1651449600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To compare indocyanine green angiography (ICGA) and swept-source wide-field optical coherence tomography angiography (SS-OCTA) for the assessment of patients with posterior uveitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>SS-OCTA montage images of 5 x 12 x 12 mm or 2 x 15 x 9 mm, covering ~70\u201390 degree of the retina of consecutive patients with posterior uveitis were acquired. The choriocapillaries and choroidal slabs were compared to findings on ICGA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty-eight eyes of 41 patients were included (mean age 47.2 \u00b1 20.4 years; 58.5% female). In 23 (34%) lesions were visible on OCTA, but not discernable on ICGA. In turn, out of the 45 eyes with clearly discernable lesions on ICGA, 22 (49%) and 21 (47%) eyes showed no corresponding areas of flow deficit on OCTA in the CC and choroidal slab, respectively. Lesion size strongly correlated among ICGA and OCTA choriocapillaries- (CC) (r = 0.99, <jats:italic>p<\/jats:italic> \u2264 0.0001) and choroidal slabs (r = 0.99, <jats:italic>p<\/jats:italic> \u2264 0.0001), respectively. The mean lesion size on the late frames of ICGA (8.45 \u00b1 5.47 mm<jats:sup>2<\/jats:sup>) was larger compared to the lesion size on OCTA CC scan (7.98 \u00b1 5.47 mm<jats:sup>2<\/jats:sup>, <jats:italic>p<\/jats:italic> \u2264 0.0001) and choroidal scan (7.69 \u00b1 5.10 mm<jats:sup>2<\/jats:sup>, <jats:italic>p<\/jats:italic> = 0.002), respectively. The lesion size on OCTA CC scan was significantly larger than on the OCTA choroidal scan (<jats:italic>p<\/jats:italic> \u2264 0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>SS-wide field OCTA may be a promising tool to assess posterior uveitis patients and may replace ICGA to a certain extent in the future.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2022.853315","type":"journal-article","created":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T06:12:06Z","timestamp":1651471926000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Comparison of Indocyanine Green Angiography and Swept-Source Wide-Field Optical Coherence Tomography Angiography in Posterior 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