{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T17:25:32Z","timestamp":1786296332405,"version":"build-2736575974"},"reference-count":138,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T00:00:00Z","timestamp":1649980800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>The analysis of synovial tissue offers the potential for the comprehensive characterization of cell types involved in arthritis pathogenesis. The studies performed to date in synovial tissue have made it possible to define synovial pathotypes, which relate to disease severity and response to treatment. Lipidomics is the branch of metabolomics that allows the quantification and identification of lipids in different biological samples. Studies in animal models of arthritis and in serum\/plasma from patients with arthritis suggest the involvement of different types of lipids (glycerophospholipids, glycerolipids, sphingolipids, oxylipins, fatty acids) in the pathogenesis of arthritis. We reviewed studies that quantified lipids in different types of tissues and their relationship with inflammation. We propose that combining lipidomics with currently used \u201comics\u201d techniques can improve the information obtained from the analysis of synovial tissue, for a better understanding of pathogenesis and the development of new therapeutic strategies.<\/jats:p>","DOI":"10.3389\/fmed.2022.857135","type":"journal-article","created":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T07:14:38Z","timestamp":1650006878000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Lipidomic Profiling in Synovial Tissue"],"prefix":"10.3389","volume":"9","author":[{"given":"Roxana","family":"Coras","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica D.","family":"Murillo-Saich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abha G.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur","family":"Kavanaugh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Guma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,4,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"100","DOI":"10.2174\/1874312901105010100","article-title":"The normal synovium","volume":"5","author":"Smith","year":"2011","journal-title":"Open Rheumatol J"},{"key":"B2","doi-asserted-by":"publisher","first-page":"107","DOI":"10.2174\/1874312901105010107","article-title":"The synovium in rheumatoid arthritis","volume":"5","author":"Hitchon","year":"2011","journal-title":"Open Rheumatol J"},{"key":"B3","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1111\/j.0105-2896.2009.00859.x","article-title":"Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis","volume":"233","author":"Bartok","year":"2010","journal-title":"Immunol Rev"},{"key":"B4","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3389\/fmed.2019.00014","article-title":"Psoriatic synovitis: singularity and potential clinical implications","volume":"6","author":"Celis","year":"2019","journal-title":"Front Med"},{"key":"B5","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1002\/1529-0131(199907)42:7<1481::AID-ANR23>3.0.CO;2-E","article-title":"Distinct vascular patterns of early synovitis in psoriatic, reactive, and rheumatoid arthritis","volume":"42","author":"Reece","year":"1999","journal-title":"Arthritis Rheum"},{"key":"B6","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1093\/rheumatology\/kev330","article-title":"Immunopathology of synovitis: from histology to molecular pathways","volume":"55","author":"van de Sande","year":"2016","journal-title":"Rheumatology"},{"key":"B7","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1093\/rheumatology\/key331","article-title":"Histologic evidence that mast cells contribute to local tissue inflammation in peripheral spondyloarthritis by regulating interleukin-17A content","volume":"58","author":"Chen","year":"2019","journal-title":"Rheumatology"},{"key":"B8","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/s41584-022-00749-9","article-title":"Synovial inflammation in osteoarthritis progression","volume":"1","author":"Sanchez-Lopez","year":"2022","journal-title":"Nat Rev Rheumatol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s41927-019-0080-9","article-title":"Health-related quality of life in patients with rheumatoid arthritis","volume":"3","author":"Katchamart","year":"2019","journal-title":"BMC Rheumatol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.rdc.2015.07.003","article-title":"Clinical features and diagnostic considerations in psoriatic Arthritis","volume":"41","author":"Gladman","year":"2015","journal-title":"Rheum Dis Clin North Am"},{"key":"B11","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1186\/s13075-020-02313-w","article-title":"Rheumatoid arthritis patients on persistent moderate disease activity on biologics have adverse 5-year outcome compared to persistent low-remission status and represent a heterogeneous group","volume":"22","author":"Genitsaridi","year":"2020","journal-title":"Arthritis Res Ther"},{"key":"B12","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1177\/1759720X17720366","article-title":"Sustained remission in rheumatoid arthritis: latest evidence and clinical considerations","volume":"9","author":"Ajeganova","year":"2017","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"B13","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1002\/art.40453","article-title":"Transcriptional profiling of synovial macrophages using minimally invasive ultrasound-guided synovial biopsies in rheumatoid arthritis","volume":"70","author":"Mandelin","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"632224","DOI":"10.3389\/fmed.2021.632224","article-title":"Ultrasound-guided synovial biopsy: a review","volume":"8","author":"Saraiva","year":"2021","journal-title":"Front Med"},{"key":"B15","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1136\/annrheumdis-2018-214539","article-title":"Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients","volume":"78","author":"Humby","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"B16","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1038\/s41467-018-02892-y","article-title":"Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis","volume":"9","author":"Mizoguchi","year":"2018","journal-title":"Nat Commun"},{"key":"B17","doi-asserted-by":"publisher","first-page":"eaau8587","DOI":"10.1126\/scitranslmed.aau8587","article-title":"HBEGF","volume":"11","author":"Kuo","year":"2019","journal-title":"Sci Transl Med"},{"key":"B18","doi-asserted-by":"publisher","first-page":"845","DOI":"10.3389\/fimmu.2020.00845","article-title":"A pauci-immune synovial pathotype predicts inadequate response to TNF\u03b1-blockade in rheumatoid arthritis patients","volume":"11","author":"Nerviani","year":"2020","journal-title":"Front Immunol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"4526","DOI":"10.1039\/C8AN01046C","article-title":"Lipid metabolism in inflammation-related diseases","volume":"143","author":"Zhang","year":"2018","journal-title":"Analyst"},{"key":"B20","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.addr.2020.06.028","article-title":"Bioactive lipids, inflammation and chronic diseases","volume":"159","author":"Leuti","year":"2020","journal-title":"Adv Drug Deliv Rev"},{"key":"B21","doi-asserted-by":"publisher","first-page":"e148552","DOI":"10.1172\/JCI148552","article-title":"Lipid metabolism in autoimmune rheumatic disease: implications for modern and conventional therapies","volume":"132","author":"Robinson","year":"2022","journal-title":"J Clin Invest"},{"key":"B22","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1016\/j.tibs.2016.08.010","article-title":"Lipidomics: techniques, applications, and outcomes related to biomedical sciences","volume":"41","author":"Yang","year":"2016","journal-title":"Trends Biochem Sci"},{"key":"B23","doi-asserted-by":"publisher","first-page":"294","DOI":"10.3390\/metabo11050294","article-title":"A novel solid phase extraction sample preparation method for lipidomic analysis of human plasma using liquid chromatography\/mass spectrometry","volume":"11","author":"Apffel","year":"2021","journal-title":"Metabolites"},{"key":"B24","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1007\/s00216-020-02473-3","article-title":"Validation of lipidomic analysis of human plasma and serum by supercritical fluid chromatography-mass spectrometry and hydrophilic interaction liquid chromatography-mass spectrometry","volume":"412","author":"Wolrab","year":"2020","journal-title":"Anal Bioanal Chem"},{"key":"B25","doi-asserted-by":"publisher","first-page":"3299","DOI":"10.1194\/jlr.M009449","article-title":"Lipidomics reveals a remarkable diversity of lipids in human plasma","volume":"51","author":"Quehenberger","year":"2010"},{"key":"B26","doi-asserted-by":"publisher","first-page":"14054","DOI":"10.1021\/acs.analchem.0c03016","article-title":"Automated annotation of sphingolipids including accurate identification of hydroxylation sites using MS","volume":"92","author":"Hartler","year":"2020","journal-title":"Anal Chem"},{"key":"B27","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.plefa.2008.09.021","article-title":"Lipidomics analysis of essential fatty acids in macrophages","volume":"79","author":"Quehenberger","year":"2008","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"B28","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1016\/j.joca.2020.12.025","article-title":"Identification of a distinct lipidomic profile in the osteoarthritic synovial membrane by mass spectrometry imaging","volume":"29","author":"Rocha","year":"2021","journal-title":"Osteoarthritis Cartilage"},{"key":"B29","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.bbalip.2011.06.009","article-title":"Lipid classification, structures and tools","volume":"1811","author":"Fahy","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"B30","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.plipres.2016.02.001","article-title":"Roles of specific lipid species in the cell and their molecular mechanism","volume":"62","author":"Kimura","year":"2016","journal-title":"Prog Lipid Res"},{"key":"B31","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.plipres.2006.01.004","article-title":"Fatty acid elongases in mammals: their regulation and roles in metabolism","volume":"45","author":"Jakobsson","year":"2006","journal-title":"Prog Lipid Res"},{"key":"B32","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.bbalip.2018.05.008","article-title":"Fatty acid activation in thermogenic adipose tissue","volume":"1864","author":"Steensels","year":"2019","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4172\/2153-0637.1000126","article-title":"Lipidomics in health and diseases-beyond the analysis of lipids","volume":"5","author":"Li","year":"2015","journal-title":"J Glycom Lipidomics"},{"key":"B34","doi-asserted-by":"publisher","first-page":"123069","DOI":"10.1016\/j.jchromb.2021.123069","article-title":"Current state-of-the-art of separation methods used in LC-MS based metabolomics and lipidomics","volume":"1188","author":"Harrieder","year":"2022","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"B35","doi-asserted-by":"publisher","first-page":"827","DOI":"10.3390\/cells9040827","article-title":"Circulating pro- and anti-inflammatory metabolites and its potential role in rheumatoid arthritis pathogenesis","volume":"9","author":"Coras","year":"2020","journal-title":"Cells"},{"key":"B36","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1073\/pnas.73.3.945","article-title":"Production of collagenase and prostaglandins by isolated adherent rheumatoid synovial cells","volume":"73","author":"Dayer","year":"1976","journal-title":"Proc Natl Acad Sci USA"},{"key":"B37","unstructured":"Distinct lipidomic signatures in synovium and synovial fluid of patients with rheumatoid arthritis versus psoriatic arthritis\n            RochaB\n            Cillero-PastorB\n            IllianoA\n            CalamiaV\n            PintoG\n            AmoresanoA\n          2021"},{"key":"B38","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1111\/j.1742-4658.2004.04489.x","article-title":"Various secretory phospholipase A2 enzymes are expressed in rheumatoid arthritis and augment prostaglandin production in cultured synovial cells","volume":"272","author":"Masuda","year":"2005","journal-title":"FEBS J"},{"key":"B39","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1002\/art.1780370508","article-title":"Interleukin-1 beta induces cytosolic phospholipase A2 and prostaglandin H synthase in rheumatoid synovial fibroblasts. Evidence for their roles in the production of prostaglandin E2","volume":"37","author":"Hulkower","year":"1994","journal-title":"Arthritis Rheum"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1172\/JCI117060","article-title":"Cyclooxygenase-1 and\u22122 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids","volume":"93","author":"Crofford","year":"1994","journal-title":"J Clin Invest"},{"key":"B41","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1093\/rheumatology\/35.8.711","article-title":"Expression of cyclooxygenase-2 in human and an animal model of rheumatoid arthritis","volume":"35","author":"Kang","year":"1996","journal-title":"Br J Rheumatol"},{"key":"B42","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/1529-0131(199801)41:1<122::AID-ART15>3.0.CO;2-8","article-title":"Expression of cyclooxygenase 1 and cyclooxygenase 2 in human synovial tissue: differential elevation of cyclooxygenase 2 in inflammatory joint diseases","volume":"41","author":"Siegle","year":"1998","journal-title":"Arthritis Rheum"},{"key":"B43","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1586\/1744666X.2.2.277","article-title":"New insights into eicosanoid biosynthetic pathways: implications for arthritis","volume":"2","author":"Kojima","year":"2006","journal-title":"Expert Rev Clin Immunol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"3439","DOI":"10.1002\/art.21390","article-title":"Effects of antirheumatic treatments on the prostaglandin E2 biosynthetic pathway","volume":"52","author":"Korotkova","year":"2005","journal-title":"Arthritis Rheum"},{"key":"B45","doi-asserted-by":"publisher","first-page":"469","DOI":"10.4049\/jimmunol.167.1.469","article-title":"Microsomal prostaglandin E synthase is regulated by proinflammatory cytokines and glucocorticoids in primary rheumatoid synovial cells","volume":"167","author":"Stichtenoth","year":"2001","journal-title":"J Immunol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/0024-3205(80)90310-0","article-title":"Is prostacyclin in the major pro-inflammatory prostanoid in joint fluid?","volume":"27","author":"Brodie","year":"1980","journal-title":"Life Sci"},{"key":"B47","doi-asserted-by":"publisher","first-page":"926968","DOI":"10.1155\/2012\/926968","article-title":"PGI2 as a regulator of inflammatory diseases","volume":"2012","author":"Dorris","year":"2012","journal-title":"Mediators Inflamm"},{"key":"B48","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1136\/ard.60.6.627","article-title":"Raised levels of F(2)-isoprostanes and prostaglandin F(2alpha) in different rheumatic diseases","volume":"60","author":"Basu","year":"2001","journal-title":"Ann Rheum Dis"},{"key":"B49","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.advms.2017.06.004","article-title":"A systematic review on the role of eicosanoid pathways in rheumatoid arthritis","volume":"63","author":"Hoxha","year":"2018","journal-title":"Adv Med Sci"},{"key":"B50","doi-asserted-by":"publisher","first-page":"9044","DOI":"10.1073\/pnas.1332766100","article-title":"Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase","volume":"100","author":"Trebino","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"B51","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1002\/art.30656","article-title":"Prostaglandin D2 regulates joint inflammation and destruction in murine collagen-induced arthritis","volume":"64","author":"Maicas","year":"2012","journal-title":"Arthritis Rheum"},{"key":"B52","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/0952-3278(90)90002-3","article-title":"Leukotriene B4 and prostaglandin E2-like activity in synovial fluid in osteoarthritis","volume":"39","author":"Sahap Atik","year":"1990","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"B53","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1002\/art.1780361017","article-title":"In vitro release of prostaglandins and leukotrienes from synovial tissue, cartilage, and bone in degenerative joint diseases","volume":"36","author":"Wittenberg","year":"1993","journal-title":"Arthritis Rheum"},{"key":"B54","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1111\/j.1472-8206.2005.00316.x","article-title":"Prostaglandin E synthase in the pathophysiology of arthritis","volume":"19","author":"Kojima","year":"2005","journal-title":"Fundam Clin Pharmacol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"R121","DOI":"10.1186\/ar3851","article-title":"Limited effect of anti-rheumatic treatment on 15-prostaglandin dehydrogenase in rheumatoid arthritis synovial tissue","volume":"14","author":"Gheorghe","year":"2012","journal-title":"Arthritis Res Ther"},{"key":"B56","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/S0014-5793(97)00904-6","article-title":"Expression of arachidonate platelet-type 12-lipoxygenase in human rheumatoid arthritis type B synoviocytes","volume":"414","author":"Liagre","year":"1997","journal-title":"FEBS Lett"},{"key":"B57","doi-asserted-by":"publisher","first-page":"R83","DOI":"10.1186\/ar2717","article-title":"Expression of 5-lipoxygenase and 15-lipoxygenase in rheumatoid arthritis synovium and effects of intraarticular glucocorticoids","volume":"11","author":"Gheorghe","year":"2009","journal-title":"Arthritis Res Ther"},{"key":"B58","first-page":"2144","article-title":"Antiinflammatory mediator lipoxin A4 and its receptor in synovitis of patients with rheumatoid arthritis","volume":"34","author":"Hashimoto","year":"2007","journal-title":"J Rheumatol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1084\/jem.20052371","article-title":"Neutrophil-derived leukotriene B4 is required for inflammatory arthritis","volume":"203","author":"Chen","year":"2006","journal-title":"J Exp Med"},{"key":"B60","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1084\/jem.20052349","article-title":"A unique requirement for the leukotriene B4 receptor BLT1 for neutrophil recruitment in inflammatory arthritis","volume":"203","author":"Kim","year":"2006","journal-title":"J Exp Med"},{"key":"B61","doi-asserted-by":"publisher","first-page":"e107890","DOI":"10.1371\/journal.pone.0107890","article-title":"5-Lipoxygenase inhibitors attenuate TNF-alpha-induced inflammation in human synovial fibroblasts","volume":"9","author":"Lin","year":"2014","journal-title":"PLoS ONE"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1007\/s00296-009-1125-y","article-title":"Regulation of TNFalpha and IL1beta in rheumatoid arthritis synovial fibroblasts by leukotriene B4","volume":"30","author":"Xu","year":"2010","journal-title":"Rheumatol Int"},{"key":"B63","doi-asserted-by":"publisher","first-page":"3049","DOI":"10.4049\/jimmunol.1001031","article-title":"Nonredundant roles for leukotriene B4 receptors BLT1 and BLT2 in inflammatory arthritis","volume":"185","author":"Mathis","year":"2010","journal-title":"J Immunol"},{"key":"B64","first-page":"863","article-title":"Effects of a single dose of methotrexate on 5- and 12-lipoxygenase products in patients with rheumatoid arthritis","volume":"19","author":"Leroux","year":"1992","journal-title":"J Rheumatol"},{"key":"B65","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1002\/art.1780350403","article-title":"Acute and chronic suppression of leukotriene B4 synthesis ex vivo in neutrophils from patients with rheumatoid arthritis beginning treatment with methotrexate","volume":"35","author":"Sperling","year":"1992","journal-title":"Arthritis Rheum"},{"key":"B66","first-page":"1537","article-title":"Zileuton, a 5-lipoxygenase inhibitor in rheumatoid arthritis","volume":"19","author":"Weinblatt","year":"1992","journal-title":"J Rheumatol"},{"key":"B67","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1136\/ard.2006.062554","article-title":"Clinical trial of a leucotriene B4 receptor antagonist, BIIL 284, in patients with rheumatoid arthritis","volume":"66","author":"Diaz-Gonzalez","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"B68","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1038\/nrrheum.2014.1","article-title":"Persisting eicosanoid pathways in rheumatic diseases","volume":"10","author":"Korotkova","year":"2014","journal-title":"Nat Rev Rheumatol"},{"key":"B69","doi-asserted-by":"publisher","first-page":"2657","DOI":"10.1172\/JCI97943","article-title":"Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators","volume":"128","author":"Serhan","year":"2018","journal-title":"J Clin Invest"},{"key":"B70","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.plipres.2010.07.005","article-title":"Old and new generation lipid mediators in acute inflammation and resolution","volume":"50","author":"Stables","year":"2011","journal-title":"Prog Lipid Res"},{"key":"B71","doi-asserted-by":"publisher","first-page":"3383","DOI":"10.4049\/jimmunol.0900327","article-title":"12\/15-lipoxygenase counteracts inflammation and tissue damage in arthritis","volume":"183","author":"Kr\u00f6nke","year":"2009","journal-title":"J Immunol"},{"key":"B72","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1007\/s00011-007-7141-z","article-title":"BML-111, a lipoxin receptor agonist, modulates the immune response and reduces the severity of collagen-induced arthritis","volume":"57","author":"Zhang","year":"2008","journal-title":"Inflamm Res"},{"key":"B73","doi-asserted-by":"publisher","first-page":"2362","DOI":"10.4049\/jimmunol.1502268","article-title":"Resolvin D3 is dysregulated in arthritis and reduces arthritic inflammation","volume":"197","author":"Arnardottir","year":"2016","journal-title":"J Immunol"},{"key":"B74","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s13075-020-2133-2","article-title":"Resolvin D1 suppresses pannus formation via decreasing connective tissue growth factor caused by upregulation of miRNA-146a-5p in rheumatoid arthritis","volume":"22","author":"Sun","year":"2020","journal-title":"Arthritis Res Ther"},{"key":"B75","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s13075-019-1852-8","article-title":"In vitroand in vivo assessment of the proresolutive and antiresorptive actions of resolvin D1: relevance to arthritis","volume":"21","author":"Benabdoun","year":"2019","journal-title":"Arthritis Res Ther"},{"key":"B76","doi-asserted-by":"publisher","first-page":"e85922","DOI":"10.1172\/jci.insight.85922","article-title":"Proresolving and cartilage-protective actions of resolvin D1 in inflammatory arthritis","volume":"1","author":"Norling","year":"2016","journal-title":"JCI Insight"},{"key":"B77","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1172\/JCI131609","article-title":"GPR101 mediates the pro-resolving actions of RvD5n-3 DPA in arthritis and infections","volume":"130","author":"Flak","year":"2020","journal-title":"J Clin Invest"},{"key":"B78","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1038\/s41591-020-0939-8","article-title":"Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis","volume":"26","author":"Alivernini","year":"2020","journal-title":"Nat Med"},{"key":"B79","doi-asserted-by":"publisher","first-page":"2168","DOI":"10.3390\/cells10082168","article-title":"S1P Increases VEGF production in osteoblasts and facilitates endothelial progenitor cell angiogenesis by inhibiting miR-16\u20135p expression via the c-Src\/FAK signaling pathway in rheumatoid arthritis","volume":"10","author":"Huang","year":"2021","journal-title":"Cells"},{"key":"B80","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/S0022-2143(98)90141-X","article-title":"Apoptosis induction in synovial fibroblasts by ceramide: in vitro and in vivo effects","volume":"131","author":"Ichinose","year":"1998","journal-title":"J Lab Clin Med"},{"key":"B81","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1006\/bbrc.2000.2239","article-title":"Regulation of rheumatoid synovial cell growth by ceramide","volume":"269","author":"Migita","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"B82","doi-asserted-by":"publisher","first-page":"e0218090","DOI":"10.1371\/journal.pone.0218090","article-title":"Upregulation of sphingosine-1-phosphate receptor 3 on fibroblast-like synoviocytes is associated with the development of collagen-induced arthritis via increased interleukin-6 production","volume":"14","author":"Inoue","year":"2019","journal-title":"PLoS ONE"},{"key":"B83","doi-asserted-by":"publisher","first-page":"117988","DOI":"10.1016\/j.lfs.2020.117988","article-title":"Sphingosine kinase 1\/sphingosine 1-phosphate\/sphingosine 1-phosphate receptor 1 pathway: a novel target of geniposide to inhibit angiogenesis","volume":"256","author":"Sun","year":"2020","journal-title":"Life Sci"},{"key":"B84","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1111\/joim.12743","article-title":"Defective glucose and lipid metabolism in rheumatoid arthritis is determined by chronic inflammation in metabolic tissues","volume":"284","author":"Arias de la Rosa","year":"2018","journal-title":"J Intern Med"},{"key":"B85","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1136\/ard.2010.144634","article-title":"Rheumatoid arthritis susceptibility genes associate with lipid levels in patients with rheumatoid arthritis","volume":"70","author":"Toms","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"B86","doi-asserted-by":"publisher","first-page":"613","DOI":"10.3858\/emm.2011.43.11.068","article-title":"Common variants at the promoter region of the APOM confer a risk of rheumatoid arthritis","volume":"43","author":"Hu","year":"2011","journal-title":"Exp Mol Med"},{"key":"B87","doi-asserted-by":"publisher","first-page":"2275","DOI":"10.1002\/art.23623","article-title":"Genome-wide association study of rheumatoid arthritis in the Spanish population: KLF12 as a risk locus for rheumatoid arthritis susceptibility","volume":"58","author":"Juli\u00e0","year":"2008","journal-title":"Arthritis Rheum"},{"key":"B88","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1002\/art.30235","article-title":"Genome-wide association study of rheumatoid arthritis in Koreans: population-specific loci as well as overlap with European susceptibility loci","volume":"63","author":"Freudenberg","year":"2011","journal-title":"Arthritis Rheum"},{"key":"B89","doi-asserted-by":"publisher","first-page":"2680","DOI":"10.1093\/hmg\/ddr161","article-title":"The human AIRE gene at chromosome 21q22 is a genetic determinant for the predisposition to rheumatoid arthritis in Japanese population","volume":"20","author":"Terao","year":"2011","journal-title":"Hum Mol Genet"},{"key":"B90","doi-asserted-by":"publisher","first-page":"e1002949","DOI":"10.1371\/journal.pgen.1002949","article-title":"Functional variants in NFKBIE and RTKN2 involved in activation of the NF-\u03baB pathway are associated with rheumatoid arthritis in Japanese","volume":"8","author":"Myouzen","year":"2012","journal-title":"PLoS Genet"},{"key":"B91","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/ng1267","article-title":"An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis","volume":"35","author":"Tokuhiro","year":"2003","journal-title":"Nat Genet"},{"key":"B92","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1002\/art.20854","article-title":"SLC22A4 polymorphisms implicated in rheumatoid arthritis and Crohn's disease are not associated with rheumatoid arthritis in a Canadian Caucasian population","volume":"52","author":"Newman","year":"2005","journal-title":"Arthritis Rheum"},{"key":"B93","doi-asserted-by":"publisher","first-page":"e1000282","DOI":"10.1371\/journal.pgen.1000282","article-title":"Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum","volume":"4","author":"Gieger","year":"2008","journal-title":"PLoS Genet"},{"key":"B94","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/nature05911","article-title":"Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls","volume":"447","author":"Consortium","year":"2007","journal-title":"Nature"},{"key":"B95","doi-asserted-by":"publisher","first-page":"e1002490","DOI":"10.1371\/journal.pgen.1002490","article-title":"Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations","volume":"8","author":"Demirkan","year":"2012","journal-title":"PLoS Genet"},{"key":"B96","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1038\/s41397-018-0040-6","article-title":"Genome-wide association study of response to tumour necrosis factor inhibitor therapy in rheumatoid arthritis","volume":"18","author":"Massey","year":"2018","journal-title":"Pharmacogenomics J"},{"key":"B97","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1093\/gerona\/glaa113","article-title":"Imbalance between omega-6- and omega-3-derived bioactive lipids in arthritis in older adults","volume":"76","author":"Coras","year":"2021","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"B98","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1002\/art.41537","article-title":"Profiling of serum oxylipins during the earliest stages of rheumatoid arthritis","volume":"73","author":"Rodr\u00edguez-Carrio","year":"2021","journal-title":"Arthritis Rheumatol"},{"key":"B99","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.imlet.2020.08.006","article-title":"Low levels of pro-resolving lipid mediators lipoxin-A4, resolvin-D1 and resolvin-E1 in patients with rheumatoid arthritis","volume":"227","author":"\u00d6zg\u00fcl \u00d6zdemir","year":"2020","journal-title":"Immunol Lett"},{"key":"B100","doi-asserted-by":"publisher","first-page":"5332","DOI":"10.1038\/s41598-021-84122-y","article-title":"Lipid, fatty acid, carnitine- and choline derivative profiles in rheumatoid arthritis outpatients with different degrees of periodontal inflammation","volume":"11","author":"Beyer","year":"2021","journal-title":"Sci Rep"},{"key":"B101","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1186\/s12967-021-03169-7","article-title":"Serum metabolomic and lipidomic profiling identifies diagnostic biomarkers for seropositive and seronegative rheumatoid arthritis patients","volume":"19","author":"Luan","year":"2021","journal-title":"J Transl Med"},{"key":"B102","doi-asserted-by":"publisher","first-page":"5420","DOI":"10.1038\/s41467-020-19176-z","article-title":"Blood pro-resolving mediators are linked with synovial pathology and are predictive of DMARD responsiveness in rheumatoid arthritis","volume":"11","author":"Gomez","year":"2020","journal-title":"Nat Commun"},{"key":"B103","doi-asserted-by":"publisher","first-page":"e0164196","DOI":"10.1371\/journal.pone.0164196","article-title":"Metabolite and lipid profiling of biobank plasma samples collected prior to onset of rheumatoid arthritis","volume":"11","author":"Surowiec","year":"2016","journal-title":"PLoS ONE"},{"key":"B104","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s11306-019-1527-0","article-title":"Pro- and anti-inflammatory eicosanoids in psoriatic arthritis","volume":"15","author":"Coras","year":"2019","journal-title":"Metabolomics"},{"key":"B105","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1186\/s13075-021-02575-y","article-title":"Differences in oxylipin profile in psoriasis versus psoriatic arthritis","volume":"23","author":"Coras","year":"2021","journal-title":"Arthritis Res Ther"},{"key":"B106","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s11306-021-01805-3","article-title":"Serum metabolic fingerprinting of psoriasis and psoriatic arthritis patients using solid-phase microextraction-liquid chromatography-high-resolution mass spectrometry","volume":"17","author":"Looby","year":"2021","journal-title":"Metabolomics"},{"key":"B107","doi-asserted-by":"publisher","first-page":"S169","DOI":"10.1016\/j.joca.2018.02.368","article-title":"Lipidomic analysis of human serum reveals elevated phospho-and sphingolipid species levels during osteoarthritis","volume":"26","author":"Kosinska","year":"2018","journal-title":"Osteoarthritis and Cartilage"},{"key":"B108","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1177\/1947603518798891","article-title":"Synovial fluid fatty acid profiles differ between osteoarthritis and healthy patients","volume":"11","author":"Van de Vyver","year":"2020","journal-title":"Cartilage"},{"key":"B109","doi-asserted-by":"publisher","first-page":"1839","DOI":"10.1016\/j.biocel.2012.06.016","article-title":"Lipidomic profiling in Crohn's disease: abnormalities in phosphatidylinositols, with preservation of ceramide, phosphatidylcholine and phosphatidylserine composition","volume":"44","author":"Sewell","year":"2012","journal-title":"Int J Biochem Cell Biol"},{"key":"B110","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1083\/jcb.201001028","article-title":"Phosphoinositide 3-kinase \u03b4 regulates membrane fission of Golgi carriers for selective cytokine secretion","volume":"190","author":"Low","year":"2010","journal-title":"J Cell Biol"},{"key":"B111","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.1093\/ibd\/izz098","article-title":"Lipidomics in Ulcerative Colitis Reveal Alteration in Mucosal Lipid Composition Associated With the Disease State","volume":"25","author":"Diab","year":"2019","journal-title":"Inflamm Bowel Dis"},{"key":"B112","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1007\/s10495-017-1384-0","article-title":"Phosphatidylethanolamine targeting for cell death imaging in early treatment response evaluation and disease diagnosis","volume":"22","author":"Elvas","year":"2017","journal-title":"Apoptosis"},{"key":"B113","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.2967\/jnumed.117.205815","article-title":"Noninvasive whole-body imaging of phosphatidylethanolamine as a cell death marker using","volume":"59","author":"Delvaeye","year":"2018","journal-title":"J Nucl Med"},{"key":"B114","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.crohns.2013.03.013","article-title":"Altered colonic mucosal availability of n-3 and n-6 polyunsaturated fatty acids in ulcerative colitis and the relationship to disease activity","volume":"8","author":"Pearl","year":"2014","journal-title":"J Crohns Colitis"},{"key":"B115","doi-asserted-by":"publisher","first-page":"e76532","DOI":"10.1371\/journal.pone.0076532","article-title":"Altered colonic mucosal Polyunsaturated Fatty Acid (PUFA) derived lipid mediators in ulcerative colitis: new insight into relationship with disease activity and pathophysiology","volume":"8","author":"Masoodi","year":"2013","journal-title":"PLoS ONE"},{"key":"B116","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1093\/ibd\/izy349","article-title":"A quantitative analysis of colonic mucosal oxylipins and endocannabinoids in treatment-na\u00efve and deep remission ulcerative colitis patients and the potential link with cytokine gene expression","volume":"25","author":"Diab","year":"2019","journal-title":"Inflamm Bowel Dis"},{"key":"B117","doi-asserted-by":"publisher","first-page":"971","DOI":"10.3390\/jcm8070971","article-title":"The lipid status in patients with ulcerative colitis: sphingolipids are disease-dependent regulated","volume":"8","author":"Bazarganipour","year":"2019","journal-title":"J Clin Med"},{"key":"B118","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/s41419-017-0214-1","article-title":"Sphingolipid de novo biosynthesis is essential for intestine cell survival and barrier function","volume":"9","author":"Li","year":"2018","journal-title":"Cell Death Dis"},{"key":"B119","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s00005-013-0221-6","article-title":"GSL-enriched membrane microdomains in innate immune responses","volume":"61","author":"Nakayama","year":"2013","journal-title":"Arch Immunol Ther Exp"},{"key":"B120","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1189\/jlb.0106069","article-title":"Induction of human neutrophil chemotaxis by Candida albicans-derived beta-1,6-long glycoside side-chain-branched beta-glucan","volume":"80","author":"Sato","year":"2006","journal-title":"J Leukoc Biol"},{"key":"B121","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s12944-016-0178-7","article-title":"The role of epidermal sphingolipids in dermatologic diseases","volume":"15","author":"Borodzicz","year":"2016","journal-title":"Lipids Health Dis"},{"key":"B122","doi-asserted-by":"publisher","first-page":"95","DOI":"10.3346\/jkms.2006.21.1.95","article-title":"Ceramides and cell signaling molecules in psoriatic epidermis: reduced levels of ceramides, PKC-alpha, and JNK","volume":"21","author":"Lew","year":"2006","journal-title":"J Korean Med Sci"},{"key":"B123","doi-asserted-by":"publisher","first-page":"859","DOI":"10.3346\/jkms.2004.19.6.859","article-title":"An inverse relationship between ceramide synthesis and clinical severity in patients with psoriasis","volume":"19","author":"Cho","year":"2004","journal-title":"J Korean Med Sci"},{"key":"B124","doi-asserted-by":"publisher","first-page":"12017","DOI":"10.1038\/srep12017","article-title":"Circulating levels of sphingosine-1-phosphate are elevated in severe, but not mild psoriasis and are unresponsive to anti-TNF-\u03b1 treatment","volume":"5","author":"Checa","year":"2015","journal-title":"Sci Rep"},{"key":"B125","doi-asserted-by":"publisher","first-page":"adv00407","DOI":"10.2340\/00015555-3766","article-title":"Metabolomic analysis of skin biopsies from patients with atopic dermatitis reveals hallmarks of inflammation, disrupted barrier function and oxidative stress","volume":"101","author":"Ilves","year":"2021","journal-title":"Acta Derm Venereol"},{"key":"B126","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1016\/j.jid.2018.02.003","article-title":"Bioactive lipid mediator profiles in human psoriasis skin and blood","volume":"138","author":"Sorokin","year":"2018","journal-title":"J Invest Dermatol"},{"key":"B127","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1111\/1523-1747.ep12874482","article-title":"Induction of epidermal hyperproliferation by topical n-3 polyunsaturated fatty acids on guinea pig skin linked to decreased levels of 13-hydroxyoctadecadienoic acid (13-hode)","volume":"94","author":"Miller","year":"1990","journal-title":"J Invest Dermatol"},{"key":"B128","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1038\/jid.2010.342","article-title":"Epidermal FABP (FABP5) regulates keratinocyte differentiation by 13(S)-HODE-mediated activation of the NF-\u03baB signaling pathway","volume":"131","author":"Ogawa","year":"2011","journal-title":"J Invest Dermatol"},{"key":"B129","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1038\/sj.jid.5701172","article-title":"G2A plays proinflammatory roles in human keratinocytes under oxidative stress as a receptor for 9-hydroxyoctadecadienoic acid","volume":"128","author":"Hattori","year":"2008","journal-title":"J Invest Dermatol"},{"key":"B130","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1194\/jlr.M087221","article-title":"LC\/MS\/MS analyses of open-flow microperfusion samples quantify eicosanoids in a rat model of skin inflammation","volume":"60","author":"Pipper","year":"2019","journal-title":"J Lipid Res"},{"key":"B131","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/S0163-7827(03)00049-3","article-title":"Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function","volume":"43","author":"Spector","year":"2004","journal-title":"Prog Lipid Res"},{"key":"B132","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.prostaglandins.2009.05.002","article-title":"5-Oxo-ETE and the OXE receptor","volume":"89","author":"Grant","year":"2009","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"B133","doi-asserted-by":"publisher","first-page":"e151911","DOI":"10.1172\/jci.insight.151911","article-title":"Phospholipase A2 enzymes represent a shared pathogenic pathway in psoriasis and pityriasis rubra pilaris","volume":"6","author":"Shao","year":"2021","journal-title":"JCI Insight"},{"key":"B134","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1111\/1523-1747.ep12696858","article-title":"Eicosanoids in acute and chronic psoriatic lesions: leukotriene B4, but not 12-hydroxy-eicosatetraenoic acid, is present in biologically active amounts in acute guttate lesions","volume":"92","author":"Fogh","year":"1989","journal-title":"J Invest Dermatol"},{"key":"B135","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1111\/j.1600-0625.1995.tb00225.x","article-title":"Incorporation of 15-hydroxyeicosatrienoic acid in specific phospholipids of cultured human keratinocytes and psoriatic plaques","volume":"4","author":"Heitmann","year":"1995","journal-title":"Exp Dermatol"},{"key":"B136","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.jdermsci.2017.10.016","article-title":"Resolvin D1 attenuates imiquimod-induced mice psoriasiform dermatitis through MAPKs and NF-\u03baB pathways","volume":"89","author":"Xu","year":"2018","journal-title":"J Dermatol Sci"},{"key":"B137","doi-asserted-by":"publisher","first-page":"1963","DOI":"10.1007\/s12035-020-02237-1","article-title":"Resolvin D1 Attenuates innate immune reactions in experimental subarachnoid hemorrhage rat model","volume":"58","author":"Liu","year":"2021","journal-title":"Mol Neurobiol"},{"key":"B138","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1038\/s41590-019-0378-1","article-title":"Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry","volume":"20","author":"Zhang","year":"2019","journal-title":"Nat Immunol"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2022.857135\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T07:14:46Z","timestamp":1650006886000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2022.857135\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,15]]},"references-count":138,"alternative-id":["10.3389\/fmed.2022.857135"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2022.857135","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,15]]},"article-number":"857135"}}