{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:00:41Z","timestamp":1792598441861,"version":"4.5.0"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T00:00:00Z","timestamp":1653350400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012401","name":"Beijing Science and Technology Planning Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012401","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Early prediction of acute kidney injury (AKI) can allow for timely interventions, but there are still few methods that are easy and convenient to apply in predicting AKI, specially targeted at patients with minimal change disease (MCD). Motivated by this, we aimed to develop a predicting model for AKI in patients with MCD within the KDIGO criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data on 401 hospitalized adult patients, whose biopsy was diagnosed as MCD from 12\/31\/2010 to 15\/7\/2021, were retrospectively collected. Among these data, patients underwent biopsy earlier formed the training set (<jats:italic>n<\/jats:italic> = 283), while the remaining patients formed the validation set (<jats:italic>n<\/jats:italic> = 118). Independent risk factors associated with AKI were analyzed. From this, the prediction model was developed and nomogram was plotted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>AKI was found in 55 of 283 patients (19%) and 15 of 118 patients (13%) in the training and validation cohorts, respectively. According to the results from lasso regression and logistic regression, it was found that four factors, including mean arterial pressure, serum albumin, uric acid, and lymphocyte counts, were independent of the onset of AKI. Incorporating these factors, the nomogram achieved a reasonably good concordance index of 0.84 (95%CI 0.77\u20130.90) and 0.75 (95%CI 0.62\u20130.87) in predicting AKI in the training and validation cohorts, respectively. Decision curve analysis suggested clinical benefit of the prediction models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our predictive nomogram provides a feasible approach to identify high risk MCD patients who might develop AKI, which might facilitate the timely treatment.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2022.862160","type":"journal-article","created":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T06:13:28Z","timestamp":1653372808000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["A Prediction Model for Acute Kidney Injury in Adult Patients With Minimal Change Disease"],"prefix":"10.3389","volume":"9","author":[{"given":"Chen","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Peng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Ling","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Ge","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Mei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Yan","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,5,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/j.kint.2018.04.024","article-title":"Acute kidney injury complicating nephrotic syndrome of minimal change disease","volume":"94","author":"Meyrier","year":"2018","journal-title":"Kidney Int."},{"key":"B2","doi-asserted-by":"publisher","first-page":"332","DOI":"10.2215\/CJN.05000516","article-title":"Minimal change disease","volume":"12","author":"Vivarelli","year":"2017","journal-title":"Clin J Am Soc Nephrol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1080\/08860220600840165","article-title":"Renal biopsy in elderly patients: a clinicopathological analysis","volume":"28","author":"Uezono","year":"2006","journal-title":"Ren Fail."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.2215\/CJN.00990209","article-title":"Renal biopsy in the very elderly","volume":"4","author":"Moutzouris","year":"2009","journal-title":"Clin J Am Soc Nephrol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/S0272-6386(00)70196-X","article-title":"Etiologies and outcome of acute renal insufficiency in older adults: a renal biopsy study of 259 cases","volume":"35","author":"Haas","year":"2000","journal-title":"Am J Kidney Dis."},{"key":"B6","doi-asserted-by":"publisher","first-page":"2192","DOI":"10.1093\/oxfordjournals.ndt.a027136","article-title":"Long-term outcome of adult-onset minimal-change nephropathy","volume":"11","author":"Mak","year":"1996","journal-title":"Nephrol Dial Transpl."},{"key":"B7","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1159\/000167603","article-title":"Minimal-change glomerulopathy of adulthood","volume":"8","author":"Korbet","year":"1988","journal-title":"Am J Nephrol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.mayocp.2017.10.021","article-title":"End-stage renal disease and mortality outcomes across different glomerulonephropathies in a large diverse US population","volume":"93","author":"Sim","year":"2018","journal-title":"Mayo Clin Proc."},{"key":"B9","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1053\/j.ajkd.2015.06.018","article-title":"Urinary, plasma, and serum biomarkers' utility for predicting acute kidney injury associated with cardiac surgery in adults: a meta-analysis","volume":"66","author":"Ho","year":"2015","journal-title":"Am J Kidney Dis."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13054-020-03179-9","article-title":"Sen, Hsu SP, Chen KL, Yang CY, Lee OKS. 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