{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T15:34:41Z","timestamp":1756308881820,"version":"3.41.2"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T00:00:00Z","timestamp":1647907200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Lymphoscintigraphy is still considered the gold standard imaging modality for diagnosing lymphedema, due to ineffective lymphatic transport resulting in edema and skin damage. However, protocol variability and poor image resolution can make the interpretation challenging. Up to now, 99 mTc-labeled colloid lymphatic travel is monitored with dual-head cameras, but single-photon emission CT (SPECT) has proved its interest. Here, we present the case of a 59-year-old-man with bilateral asymmetric lower limb edema which was explored using dual-head and new 3D-ring cadmium -zinc-telluride (CZT) SPECT cameras, confirming bilateral lower limb lymphatic dysfunction. In line with other recently published reports, this case report promotes the use of SPECT\/CT in the lymphoscintigraphic exploration of lower limb edema. The recognition of the clinicopathologic features of lower limb edema is required to prevent missed diagnoses, such as compressive disease, tumors, etc., as well as to better influence the management of patients.<\/jats:p>","DOI":"10.3389\/fmed.2022.866541","type":"journal-article","created":{"date-parts":[[2022,3,27]],"date-time":"2022-03-27T18:47:46Z","timestamp":1648406866000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Case Report: Potential Applications of Using a 3D-Ring CZT SPECT for Lymphoscintigraphic Exploration of Lower Limb Edema"],"prefix":"10.3389","volume":"9","author":[{"given":"H\u00e9l\u00e8ne","family":"Besse","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthieu","family":"Bailly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,3,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"13691","DOI":"10.1038\/s41598-019-49554-7","article-title":"Scintigraphic investigations of the deep and superficial lymphatic systems in the evaluation of lower limb oedema","volume":"9","author":"Barbieux","year":"2019","journal-title":"Sci Rep."},{"key":"B2","first-page":"1","article-title":"Relationship between lymphoscintigraphy and clinical findings in lower limb lymphedema (LO): toward a comprehensive staging","volume":"41","author":"Pecking","year":"2008","journal-title":"Lymphology."},{"key":"B3","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1007\/s00259-002-1020-1","article-title":"Dynamic lymph flow imaging in patients with oedema of the lower limb for evaluation of the functional outcome after autologous lymph vessel transplantation: an 8-year follow-up study","volume":"30","author":"Weiss","year":"2003","journal-title":"Eur J Nucl Med Mol Imaging."},{"key":"B4","doi-asserted-by":"publisher","first-page":"188","DOI":"10.3348\/kjr.2015.16.1.188","article-title":"Primary lymphedema of the lower limb: the clinical utility of single photon emission computed tomography\/CT","volume":"16","author":"Weiss","year":"2015","journal-title":"Korean J Radiol."},{"key":"B5","first-page":"106","article-title":"Contributions of SPECT\/CT imaging to the lymphoscintigraphic investigations of the lower limb lymphedema","volume":"46","author":"Baulieu","year":"2013","journal-title":"Lymphology."},{"key":"B6","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.remnie.2019.03.003","article-title":"Lymphoscintigraphy for the evaluation of limb lymphatic flow disorders: Report of technical procedural standards from an Italian Nuclear Medicine expert panel","volume":"38","author":"Maccauro","year":"2019","journal-title":"Rev Esp Med Nucl Imagen Mol."},{"key":"B7","doi-asserted-by":"crossref","DOI":"10.3389\/fnume.2021.740275","article-title":"Bone scintigraphy of vertebral fractures with a whole-body CZT camera in a PET-like utilization","volume-title":"Front Nucl Med.","author":"Bahloul","year":"2021"},{"key":"B8","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1001\/archsurg.138.2.152","article-title":"Differential diagnosis, investigation, and current treatment of lower limb lymphedema","volume":"138","author":"Tiwari","year":"2003","journal-title":"Arch Surg."},{"key":"B9","first-page":"43","article-title":"The third circulation: radionuclide lymphoscintigraphy in the evaluation of lymphedema","volume":"44","author":"Szuba","year":"2003","journal-title":"J Nucl Med."},{"key":"B10","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1097\/00003072-199308000-00003","article-title":"Lymphoscintigraphy. 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