{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:30:08Z","timestamp":1788449408437,"version":"build-2803163510"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T00:00:00Z","timestamp":1652918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>We aimed to investigate the clinical, laboratory, and electrocardiographic (ECG) findings of colchicine poisoning and to evaluate if there is a correlation between them and the two major outcomes of this toxicity which are respiratory\/cardiovascular failure and death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Medical records of 34 colchicine-intoxicated patients that were treated in our center during the past 10 years were retrospectively evaluated. The patient's clinical presentation, vital signs, laboratory tests, ECGs, and outcomes were reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Abdominal pain, and hypotension at presentation had significant correlation with mortality (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.003, OR: 2.2 [4.1, 7.9],\n                      <jats:italic>p<\/jats:italic>\n                      = 0.029, OR: 13.0 [1.5, 111.8]). Mortality significantly occurred in those with sinus tachycardia, hypokalemia, metabolic acidosis, and impaired liver and kidney function tests (\n                      <jats:italic>p<\/jats:italic>\n                      -values = 0.025, 0.007, 0.04, and 0.008, respectively). All the patients had some ECG abnormalities. Most frequent ECG abnormalities were pathologic ST segment elevation and depression (70%), left atrial enlargement (48%), and sinus tachycardia (37%), PR elevation in aVR lead (37%), and T wave inversion (37%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Colchicine toxicity is a dangerous entity regarding the cardiovascular events and requires close general and cardiac monitoring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2022.872528","type":"journal-article","created":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T01:48:01Z","timestamp":1652924881000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical, Laboratory, and Electrocardiographic Findings in Colchicine Toxicity: 10 Years of Experience"],"prefix":"10.3389","volume":"9","author":[{"given":"Mehdi","family":"Sheibani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasim","family":"Zamani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir Houshang","family":"Gerami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Akhondi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Hassanian-Moghaddam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,5,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1093\/jat\/21.1.70","article-title":"Colchicine poisoning: report of a fatal case and presentation of an HPLC procedure for body fluid and tissue analyses","volume":"21","author":"Kintz","year":"1997","journal-title":"J Anal Toxicol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1093\/jat\/26.6.365","article-title":"Application of LC-MS analysis to a colchicine fatality","volume":"26","author":"Jones","year":"2002","journal-title":"J Anal Toxicol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.semarthrit.2015.06.013","article-title":"Colchicine\u2013update on mechanisms of action and therapeutic uses","volume":"45","author":"Leung","year":"2015","journal-title":"Semin Arthritis Rheum."},{"key":"B4","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/S0736-4679(02)00430-4","article-title":"Deaths associated with inappropriate intravenous colchicine administration","volume":"22","author":"Bonnel","year":"2002","journal-title":"J Emerg Med."},{"key":"B5","first-page":"1625","article-title":"Aplasie m\u00e9dullaire apr\u00e8s intoxication aigu\u00eb \u00e0 la colchicine. 20 cas [Medullary aplasia after acute colchicine poisoning. 20 cases]","volume":"6","author":"Bismuth","year":"1977","journal-title":"Nouv Presse Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"61","DOI":"10.3399\/bjgp17X688993","article-title":"Colchicine in overdose","volume":"67","author":"Roddy","year":"2017","journal-title":"Br J Gen Pract."},{"key":"B7","doi-asserted-by":"publisher","first-page":"407","DOI":"10.3109\/15563650.2010.495348","article-title":"Colchicine poisoning: the dark side of an ancient drug","volume":"48","author":"Finkelstein","year":"2010","journal-title":"Clin Toxicol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"307","DOI":"10.4081\/reumatismo.2013.720","article-title":"Acute colchicine overdose: report of three cases","volume":"65","author":"Aghabiklooei","year":"2014","journal-title":"Reumatismo."},{"key":"B9","unstructured":"Colchicine (Oral Route) Proper Use"},{"key":"B10","first-page":"e53","article-title":"Clinical manifestations and outcomes of colchicine poisoning cases; 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