{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T15:29:04Z","timestamp":1782833344856,"version":"3.54.5"},"reference-count":14,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>End-stage renal disease (ESRD) is a global health problem with a high incidence (<jats:xref>1<\/jats:xref>) and a steadily increasing prevalence (<jats:xref>2<\/jats:xref>). Secondary hyperparathyroidism (SHPT) is a common and serious complication of chronic renal failure (CRF) in dialysis patients (<jats:xref>3<\/jats:xref>). It is mainly manifested as parathyroid hyperplasia caused by abnormal calcium and phosphorus metabolism and active vitamin D resistance, resulting in excessive secretion of parathyroid hormone (PTH), which leads to complications such as bone deformity, osteoarthralgia, pruritus, ectopic calcification, and cardiovascular calcification in CKD patients, significantly reducing the quality of life in CKD patients (<jats:xref>4<\/jats:xref>, <jats:xref>5<\/jats:xref>). In patients with chronic kidney disease, secondary parathyroid gland hyperplasia needs to be treated as early as possible (<jats:xref>6<\/jats:xref>). Currently, there are a variety of treatment options, including vitamin D receptor agonists, xenacax hydrochloride, parathyroidectomy and ablation techniques, etc. (<jats:xref>7<\/jats:xref>, <jats:xref>8<\/jats:xref>). Medical treatment is the main choice among these treatments, but it is invalid in patients with severe hyperparathyroidism. So, parathyroidectomy is suggested to do in those patients (<jats:xref>9<\/jats:xref>). However, many dialysis patients who have severe cardiopulmonary dysfunction cannot tolerate the trauma caused by surgery as the concept of minimally invasive surgery has been gradually introduced into all fields of surgery and medical treatment. Traditional surgery is no longer the only option. Radiofrequency ablation has been widely applied due to its advantages of less trauma, simple operation, and good repeatability. It has been reported to achieve good effects in treating secondary hyperparathyroidism patients (<jats:xref>8<\/jats:xref>). This case reports that one severe secondary hyperparathyroidism patient gets good therapeutic results from parathyroid radiofrequency ablation.<\/jats:p>","DOI":"10.3389\/fmed.2022.876692","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T08:47:20Z","timestamp":1658479640000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Severe secondary hyperparathyroidism in a chronic kidney disease patient treated with Radiofrequency ablation: One case report"],"prefix":"10.3389","volume":"9","author":[{"given":"Gulimire","family":"Muhetaer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,22]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","DOI":"10.1053\/j.ajkd.2018.01.002","article-title":"US renal data system 2017 annual data report: epidemiology of kidney disease in the United States.","volume":"71","author":"Saran","year":"2018","journal-title":"Am J Kidney Dis."},{"key":"B2","first-page":"997","article-title":"Prevalence of reduced kidney function and albuminuria in older adults: the Berlin initiative study.","volume":"32","author":"Ebert","year":"2017","journal-title":"Nephrol Dial Transplant."},{"key":"B3","doi-asserted-by":"publisher","first-page":"702","DOI":"10.4103\/1319-2442.113858","article-title":"Association between pruritus and serum concentrations of parathormone, calcium and phosphorus in hemodialysis patients.","volume":"24","author":"Tajbakhsh","year":"2013","journal-title":"Saudi J Kidney Dis Transpl."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.1093\/ndt\/gfq304","article-title":"Calcium, phosphorus, PTH and death rates in a large sample of dialysis patients from Latin America. The CORES Study.","volume":"26","author":"Naves-D\u00edaz","year":"2011","journal-title":"Nephrol Dial Transplant."},{"key":"B5","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1002\/hed.24657","article-title":"Efficacy and safety of ultrasound-guided radiofrequency ablation of hyperplastic parathyroid gland for secondary hyperparathyroidism associated with chronic kidney disease.","volume":"39","author":"Peng","year":"2017","journal-title":"Head Neck."},{"key":"B6","first-page":"S1","article-title":"KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD).","volume":"113","year":"2009","journal-title":"Kidney Int Suppl."},{"key":"B7","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jpsychores.2016.12.013","article-title":"Quality of sleep in renal transplant recipients and patients on hemodialysis.","volume":"93","author":"Liaveri","year":"2017","journal-title":"J Psychosom Res."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1016\/j.ultrasmedbio.2015.08.021","article-title":"Efficacy of ablation therapy for secondary hyperparathyroidism by ultrasound guided percutaneous thermoablation.","volume":"42","author":"Zhao","year":"2016","journal-title":"Ultrasound Med Biol."},{"key":"B9","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.kint.2017.04.006","article-title":"Executive summary of the 2017 KDIGO chronic kidney disease-mineral and bone disorder (CKD-MBD) guideline update: what\u2019s changed and why it matters.","volume":"92","author":"Ketteler","year":"2017","journal-title":"Kidney Int."},{"key":"B10","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1148\/radiol.2016151875","article-title":"US-guided microwave ablation of hyperplastic parathyroid glands: safety and efficacy in patients with end-stage renaldiseae \u2013 a pilot study.","volume":"282","author":"Zhuo","year":"2017","journal-title":"Radiology."},{"key":"B11","doi-asserted-by":"publisher","first-page":"e137","DOI":"10.11622\/smedj.2013092","article-title":"Percutaneous sonography-guided radio-frequency ablation in the management of parathyroid adenoma.","volume":"54","author":"Xu","year":"2013","journal-title":"Singapore Med J."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/srep26841","article-title":"Diagnostic accuracy study of intraoperative and perioperative serum intact PTH level for successful parathyroidectomy in 501 secondary hyperparathyroidism patients.","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci Rep."},{"key":"B13","doi-asserted-by":"publisher","first-page":"29","DOI":"10.5935\/1808-8694.20140008","article-title":"Localization of ectopic and supernumerary parathyroid glands in patients with secondary and tertiary hyperparathyroidism: surgical description and correl ation with preoperative ultrasonography and Tc99m Sestamibi scintigraphy.","volume":"80","author":"Andrade","year":"2014","journal-title":"Braz J Otorhinolaryngol."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-63299-8","article-title":"Efficacy of ultrasound-guided radiofrequency ablation of parathyroid hyperplasia: single session vs. two-session for effect on hypocalcemia.","volume":"10","author":"Zeng","year":"2020","journal-title":"Sci Rep."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2022.876692\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T08:47:27Z","timestamp":1658479647000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2022.876692\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,22]]},"references-count":14,"alternative-id":["10.3389\/fmed.2022.876692"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2022.876692","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,22]]},"article-number":"876692"}}