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Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Studies evaluating the relationship between intrauterine hematoma in the first trimester and prenatal complications are conflicting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate whether intrauterine hematoma identified in the first trimester in women with singleton pregnancies is associated with adverse perinatal outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Search Strategy<\/jats:title><jats:p>A comprehensive literature search of three databases (Embase, PubMed, and Web of Science) was performed up to September 2021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Selection Criteria<\/jats:title><jats:p>Cohort and case-control studies that have evaluated the relationship between intrauterine hematoma identified before 14 gestational weeks and the risk of prenatal complications, in women with a singleton pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Data Collection and Analysis<\/jats:title><jats:p>Two members of our team independently assessed the studies for inclusion, collected the data of interest, and assessed the risk of bias, and calculated pooled odds ratios (ORs) using random-effects models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Results<\/jats:title><jats:p>Nine studies, including 1,132 women with intrauterine hematoma and 11,179 controls met the inclusion criteria. Intrauterine hematoma increased the risk of spontaneous abortion [OR 2.15, 95% confidence interval (CI) 1.23\u20133.75], preterm birth (OR 1.83, 95% CI 1.37\u20132.43), fetal growth restriction (OR 2.33, 95% CI 1.13\u20134.83) and placental abruption (OR 3.16, 95% CI 1.23\u20138.13). No statistically significant association was found between intrauterine hematoma and preeclampsia (OR 1.30, 95% CI 0.87\u20131.94).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Intrauterine hematoma in the first trimester of pregnancy increases the risk of spontaneous abortion, preterm birth, placental abruption, and fetal growth restriction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Systematic Review Registration<\/jats:title><jats:p><jats:ext-link>https:\/\/www.crd.york.ac.uk\/PROSPERO\/<\/jats:ext-link>.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2022.892146","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T05:32:31Z","timestamp":1655443951000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Intrauterine Hematoma in the First Trimester and Pregnancy Complications: A Systematic Review and Meta-Analysis"],"prefix":"10.3389","volume":"9","author":[{"given":"Zhao-juan","family":"Qin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1186\/s12884-017-1539-6","article-title":"Intra- versus retroplacental hematomas: a retrospective case-control study on pregnancy outcomes","volume":"17","author":"Ott","year":"2017","journal-title":"BMC Pregnancy Childbirth."},{"key":"B2","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1097\/00006254-199302000-00001","article-title":"Subchorionic hematoma: a review","volume":"48","author":"Pearlstone","year":"1993","journal-title":"Obstet Gynecol Surv."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1002\/jum.14524","article-title":"Subchorionic hematoma: correlation of grading techniques with first-trimester pregnancy outcome","volume":"37","author":"Heller","year":"2018","journal-title":"J Ultrasound Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1002\/uog.20861","article-title":"First-trimester intrauterine hematoma and pregnancy complications","volume":"55","author":"Al-Memar","year":"2020","journal-title":"Ultrasound Obstet Gynecol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"330","DOI":"10.14366\/usg.18006","article-title":"The impact of first-trimester intrauterine hematoma on adverse perinatal outcomes","volume":"37","author":"Peixoto","year":"2018","journal-title":"Ultrasonography."},{"key":"B6","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1097\/AOG.0000000000003360","article-title":"Association between first-trimester subchorionic hematomas and pregnancy loss in singleton pregnancies","volume":"134","author":"Naert","year":"2019","journal-title":"Obstet Gynecol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"239","DOI":"10.5152\/jtgga.2014.14170","article-title":"The effects of subchorionic hematoma on pregnancy outcome in patients with threatened abortion","volume":"15","author":"Sukur","year":"2014","journal-title":"J Turk Ger Gynecol Assoc."},{"key":"B8","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1097\/AOG.0b013e3181e90170","article-title":"Ultrasound-detected subchorionic hemorrhage and the obstetric implications","volume":"116","author":"Norman","year":"2010","journal-title":"Obstet Gynecol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1111\/j.1471-0528.1981.tb00936.x","article-title":"Intrauterine haematoma. 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