{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:00:21Z","timestamp":1753891221566,"version":"3.41.2"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T00:00:00Z","timestamp":1657152000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p><jats:italic>Campylobacter jejuni<\/jats:italic> (<jats:italic>C. jejuni<\/jats:italic>), a Gram-negative bacterium, belongs to microaerobic bacteria. We reported a 21-year-old male patient diagnosed with hemophagocytic lymphohistiocytosis (HLH) due to <jats:italic>C. jejuni<\/jats:italic> infection, who presented with multiple clinical manifestations of peripheral nerve injury, such as ophthalmoplegia, facial paralysis, and urinary retention during the treatment. Electromyography showed neurogenic injury and the final diagnosis was Guillain-Barre Syndrome (GBS). After treatment of dexamethasone combined with immunoglobulin, the patient was discharged from the hospital with partial recovery of neurological symptoms.<\/jats:p>","DOI":"10.3389\/fmed.2022.895923","type":"journal-article","created":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T07:33:07Z","timestamp":1657179187000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Campylobacter jejuni-Associated Hemophagocytic Lymphohistiocytosis and Guillain-Barre Syndrome: A Case Report"],"prefix":"10.3389","volume":"9","author":[{"given":"Fang-e","family":"Shi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei-fang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-jie","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gui-ying","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-hong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"Hvac024","DOI":"10.1093\/Clinchem\/Hvac024","article-title":"Optimized Sequencing Adaptors Enable Rapid and Real-Time Metagenomic Identification of Pathogens During Runtime of Sequencing [Published Online Ahead of Print, 2022 Mar 15]","volume":"2022","author":"Zhang","year":"2022","journal-title":"Clin Chem"},{"key":"B2","first-page":"608","article-title":"Serum Antibody to Campylobacter Jejuni (CJ) in Guillain-Barre Syndrome (GBS) Patients and Its Significance","volume":"17","author":"Hao","year":"2001","journal-title":"Chinese J Immunol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1038\/Nrgastro.2011.191","article-title":"The Clinical Importance of Emerging Campylobacter Species","volume":"8","author":"Man","year":"2011","journal-title":"Nat Rev Gastroenterol Hepatol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1128\/CMR.00006-15","article-title":"Global Epidemiology of Campylobacter Infection","volume":"28","author":"Kaakoush","year":"2015","journal-title":"Clin Microbiol Rev."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1007\/S10096-019-03575-2","article-title":"Potential False-Positive Urine Legionella Enzyme Immunoassay Test Results","volume":"38","author":"Como","year":"2019","journal-title":"Eur J Clin Microbiol Infect Dis."},{"key":"B6","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/S12952-016-0047-Y","article-title":"V\u00e9lez LA. Comparison of Serological Methods With PCR-Based Methods for the Diagnosis of Community-Acquired Pneumonia Caused by Atypical Bacteria","volume":"15","author":"Herrera","year":"2016","journal-title":"J Negat Results Biomed."},{"key":"B7","doi-asserted-by":"publisher","first-page":"545","DOI":"10.3329\/Jhpn.V28i6.6602","article-title":"Quantifying the Association Between Campylobacter Infection and Guillain-Barr\u00e9 Syndrome: A Systematic Review","volume":"28","author":"Poropatich","year":"2010","journal-title":"J Health Popul Nutr."},{"key":"B8","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/S1474-4422(08)70215-1","article-title":"Clinical Features, Pathogenesis, and Treatment of Guillain-Barr\u00e9 Syndrome","volume":"7","author":"Van Doorn","year":"2008","journal-title":"Lancet Neurol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"877","DOI":"10.3760\/cma.j.issn.1006","volume":"52","year":"2019","journal-title":"Chinese J Neurol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1136\/jcp.2006.046284","article-title":"Bickerstaff's Brainstem Encephalitis Related to Campylobacter Jejuni Gastroenteritis","volume":"60","author":"Hussain","year":"2007","journal-title":"J Clin Pathol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1111\/ene.12769","article-title":"Anti-GQ1b Antibody Syndrome: Anti-Ganglioside Complex Reactivity Determines Clinical Spectrum","volume":"23","author":"Fukami","year":"2016","journal-title":"Eur J Neurol."},{"key":"B12","article-title":"Miller Fisher Syndrome","volume-title":"StatPearls","author":"Rocha Cabrero","year":"2021"},{"key":"B13","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.Jneuroim.2016.07.021","article-title":"Chiba A. Ca(2+)-Dependent Anti-GQ1b Antibody in GQ1b-Seronegative Fisher Syndrome and Related Disorders","volume":"298","author":"Uchibori","year":"2016","journal-title":"J Neuroimmunol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1111\/j.1365-2141.2007.06922.x","article-title":"Frequency and Spectrum of Central Nervous System Involvement in 193 Children With Haemophagocytic Lymphohistiocytosis","volume":"140","author":"Horne","year":"2008","journal-title":"Br J Haematol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1146\/Annurev-Pathol-020117-043625","article-title":"Hemophagocytic Lymphohistiocytosis","volume":"13","author":"Al-Samkari","year":"2018","journal-title":"Annu Rev Pathol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.1212\/01.wnl.0000244468.22377.6b","article-title":"Relationship of Bacterial Strains to Clinical Syndromes of Campylobacter-Associated Neuropathies","volume":"67","author":"Kimoto","year":"2006","journal-title":"Neurology."},{"key":"B17","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.It.2022.02.003","article-title":"Guillain-Barr\u00e9 Syndrome: Expanding the Concept of Molecular Mimicry","volume":"43","author":"Laman","year":"2022","journal-title":"Trends Immunol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"2064706","DOI":"10.1080\/19490976.2022.2064706","article-title":"Campylobacter Jejuni Induces Autoimmune Peripheral Neuropathy via Sialoadhesin and Interleukin-4 Axes","volume":"14","author":"Malik","year":"2022","journal-title":"Gut Microbes"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2022.895923\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T07:33:09Z","timestamp":1657179189000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2022.895923\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,7]]},"references-count":18,"alternative-id":["10.3389\/fmed.2022.895923"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2022.895923","relation":{},"ISSN":["2296-858X"],"issn-type":[{"type":"electronic","value":"2296-858X"}],"subject":[],"published":{"date-parts":[[2022,7,7]]},"article-number":"895923"}}