{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T07:30:58Z","timestamp":1780990258780,"version":"3.54.1"},"reference-count":20,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T00:00:00Z","timestamp":1657756800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim was to quantify and compare papillary and peripapillary vessel density in amblyopic eyes of adults and age-matched controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross-sectional study involved 20 eyes from 10 subjects with anisometropic amblyopia and 12 eyes of 6 age- and gender-matched healthy controls. Optical coherence tomography angiography (OCTA) was performed on all participants. SPSS 20 was used for data analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean subject age was 35.7 \u00b1 10.04 years (range 18\u201347) in the amblyopia group and 34.67 \u00b1 6.92 years (range 23\u201342) in the control group. The diopter of amblyopia ranges from +3 to +5 ds. The mean inside optic disk capillary vessel density (CVD) was 41.88 \u00b1 6.55% in amblyopic eyes, 49.23 \u00b1 6.55% in fellow eyes, and 50.23 \u00b1 4% in control eyes (<jats:italic>p<\/jats:italic> &amp;lt; 0.05). The mean inside optic disk all vessel density (AVD) was 52.97 \u00b1 6.71% in amblyopic eyes, 59.87 \u00b1 4.59% in fellow eyes, and 60.45 \u00b1 2.8% in control eyes (<jats:italic>p<\/jats:italic> &amp;lt; 0.05). The amblyopic eye of participants showed a decrease in vessel density in the inside optic disk than in the fellow eyes and healthy subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our present study revealed lower vessel density inside the optic disc of adult patients with anisometropic amblyopia. However, further studies are really needed to determine the clinical relevance of this finding.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2022.903228","type":"journal-article","created":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T08:07:36Z","timestamp":1657786056000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Analysis of Optic Nerve in Adults With Amblyopia Using OCTA"],"prefix":"10.3389","volume":"9","author":[{"given":"Hui","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonggang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingfen","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/612086","article-title":"Altered functional connectivity of the primary visual cortex in subjects with amblyopia","author":"Ding","year":"2013","journal-title":"Neural Plast"},{"key":"B2","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.jaapos.2018.05.014","article-title":"Evaluation of retinal structure in unilateral amblyopia using spectral domain optical coherence tomography","volume":"22","author":"Lekskul","year":"2018","journal-title":"J Am Assoc Pediatr Ophthalmol Strabismus."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1080\/02713683.2017.1349153","article-title":"The evaluation of anatomic and functional changes in unilateral moderate amblyopic eyes using optical coherence tomography and pupil cycle time","volume":"42","author":"Kusbeci","year":"2017","journal-title":"Curr Eye Res."},{"key":"B4","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1080\/09273972.2017.1318152","article-title":"Choroidal thickness in strabismus and amblyopia cases","volume":"25","author":"Niyaz","year":"2017","journal-title":"Strabismus."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1007\/s10792-020-01345-0","article-title":"Quantitative analysis of macular and peripapillary microvasculature in adults with anisometropic amblyopia","volume":"40","author":"Dereli Can","year":"2020","journal-title":"Int Ophthalmol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1097\/IAE.0000000000001407","article-title":"Reproducibility of vessel density measurement with optical coherence tomography angiography in eyes with and without retinopathy","volume":"37","author":"You","year":"2017","journal-title":"Retina."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.1097\/IAE.0000000000001426","article-title":"Reproducibility and reliability of optical coherence tomography angiography for foveal avascular zone evaluation and measurement in different settings","volume":"37","author":"La Spina","year":"2017","journal-title":"Retina."},{"key":"B8","doi-asserted-by":"publisher","first-page":"336","DOI":"10.5301\/ejo.5000858","article-title":"Reproducibility and repeatability of foveal avascular zone area measurements using swept-source optical coherence tomography angiography in healthy subjects","volume":"27","author":"Mastropasqua","year":"2017","journal-title":"Eur J Ophthalmol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"e0243074","DOI":"10.1371\/journal.pone.0243074","article-title":"Retinal vascular metrics difference by comparison of two image acquisition modes using a novel OCT angiography prototype","volume":"15","author":"Di Antonio","year":"2020","journal-title":"PLoS ONE."},{"key":"B10","doi-asserted-by":"publisher","first-page":"e82763","DOI":"10.1371\/journal.pone.0082763","article-title":"Refractive error, visual acuity and causes of vision loss in children in Shandong, China. 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