{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T21:18:55Z","timestamp":1788211135577,"version":"build-2803163510"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T00:00:00Z","timestamp":1653004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>\n                    We aim to compare the effects of sugammadex on postoperative nausea and vomiting (PONV) with those of neostigmine\u2013atropine mixture. A total of 136 American Society of Anesthesiology (ASA) I or II patients, aged 18 to 65 years who underwent ear, nose, and throat (ENT) surgery under general anesthesia, were recruited in this prospective, randomized, double-blind study to receive either sugammadex 2 mg\/kg or neostigmine 2.5 mg with atropine 1 mg for reversal of neuromuscular blockade. PONV scores and the need for the rescue of anti-emetic were assessed upon arrival in the post-anesthesia recovery unit and at 1-, 6-, 12-, and 24-h post-reversal. The incidence of PONV was significantly lower in patients who received sugammadex (3%) compared to patients who received neostigmine\u2013atropine mixture (20%) at 6 h postoperative (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.013). The incidence of PONV was comparable at other time intervals. None of the sugammadex recipients require rescue antiemetic whereas two patients from the neostigmine\u2013atropine group required rescue antiemetic at 1 and 6 h post-reversal, respectively. The need for the rescue antiemetic was not statistically significant. We concluded that reversal of neuromuscular blockade with sugammadex showed lower incidence of PONV compared to neostigmine\u2013atropine combination in the first 6 h post-reversal.\n                  <\/jats:p>","DOI":"10.3389\/fmed.2022.905131","type":"journal-article","created":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T01:12:53Z","timestamp":1653009173000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Effects of Sugammadex and Neostigmine on Post-operative Nausea and Vomiting in ENT Surgery"],"prefix":"10.3389","volume":"9","author":[{"given":"Nik Izyan Syaizana Nik","family":"Mat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih Nie","family":"Yeoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Maaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaafar Md","family":"Zain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna Su Min","family":"Ooi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,5,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"388","DOI":"10.4103\/0259-1162.179310","article-title":"Postoperative nausea and vomiting: a simple yet complex problem","volume":"10","author":"Shaikh","year":"2016","journal-title":"Anesthesia, Essays Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1097\/00000542-199909000-00022","article-title":"A simplified risk score for predicting postoperative nausea and vomiting: conclusions from cross-validations between two centers","volume":"91","author":"Apfel","year":"1999","journal-title":"J Am Soc Anesthesiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s12070-010-0012-x","article-title":"Nausea and vomiting after ENT surgeries: a comparison between ondansetron, metoclopramide and small dose of propofol","volume":"62","author":"Mishra","year":"2010","journal-title":"Indian J Otolaryngol Head Neck Surg."},{"key":"B4","doi-asserted-by":"crossref","DOI":"10.1017\/9781108591317","volume-title":"Pharmacology for Anaesthesia and Intensive Care","author":"Peck","year":"2021"},{"key":"B5","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.jclinane.2014.08.010","article-title":"Comparison of sugammadex and conventional reversal on postoperative nausea and vomiting: a randomized, blinded trial","volume":"27","author":"Koyuncu","year":"2015","journal-title":"J Clin Anesth."},{"key":"B6","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1007\/s00266-013-0067-7","article-title":"The management of post-operative nausea and vomiting: current thoughts and protocols","volume":"37","author":"Sweis","year":"2013","journal-title":"Aesthetic Plast Surg."},{"key":"B7","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1111\/aas.12813","article-title":"Effects of sugammadex vs. pyridostigmine\u2013glycopyrrolate on postrolate on postx vs. C, Jung Y, Woo Yhts and protocols","volume":"61","author":"Lee","year":"2017","journal-title":"Acta Anaesthesiologica Scandinavica."},{"key":"B8","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1093\/bja\/82.3.379","article-title":"Omitting antagonism of neuromuscular block: effect on postoperative nausea and vomiting and risk of residual paralysis. 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