{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:01:24Z","timestamp":1753891284315,"version":"3.41.2"},"reference-count":50,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T00:00:00Z","timestamp":1656892800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>The T12811C mitochondrial DNA (mtDNA) mutation has been reported in Leber hereditary optic neuropathy (LHON) previously, with vision loss as the main manifestation. The involvement of other organ systems, including the central and peripheral nervous system, heart, and extraocular muscles, has not been well described. This case series report investigated four patients with T12811C mtDNA mutation, verified through a next generation sequencing. Two male patients presented with bilateral subacute visual decrease combined with involvement of multiple organ systems: leukoencephalopathy, hypertrophic cardiomyopathy, neurosensory deafness, spinal cord lesion and peripheral neuropathies. Two female patients presented with progressive ptosis and ophthalmoplegia, one of whom also manifested optic atrophy. This study found out that patients harboring T12811C mtDNA mutation manifested not only as vision loss, but also as a multi-system disorder affecting the nervous system, heart, and extraocular muscles.<\/jats:p>","DOI":"10.3389\/fmed.2022.912103","type":"journal-article","created":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T04:59:20Z","timestamp":1656910760000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Varying Clinical Phenotypes of Mitochondrial DNA T12811C Mutation: A Case Series Report"],"prefix":"10.3389","volume":"9","author":[{"given":"Qingdan","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaoyi","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinghuai","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guohong","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,4]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/S0002-9394(14)72445-6","article-title":"Mitochondria and Leber\u2019s hereditary optic neuropathy.","volume":"109","author":"Newman","year":"1990","journal-title":"Am J Ophthalmol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1136\/jmg.2007.054270","article-title":"Inherited mitochondrial optic neuropathies.","volume":"46","author":"Yu-Wai-Man","year":"2009","journal-title":"J Med Genet."},{"key":"B3","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/j.bbabio.2009.02.024","article-title":"Retinal ganglion cell neurodegeneration in mitochondrial inherited disorders.","volume":"1787","author":"Carelli","year":"2009","journal-title":"Biochim Biophys Acta."},{"key":"B4","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1136\/jmg.39.3.162","article-title":"Leber hereditary optic neuropathy.","volume":"39","author":"Man","year":"2002","journal-title":"J Med Genet."},{"key":"B5","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s11940-010-0100-y","article-title":"Leber\u2019s hereditary optic neuropathy.","volume":"13","author":"Sadun","year":"2011","journal-title":"Curr Treat Option Neurol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1007\/Bf00868531","article-title":"Characterization of basal ganglia dysfunction in Leber \u2018Plus\u2019 disease.","volume":"243","author":"Hanemann","year":"1996","journal-title":"J Neurol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1076\/noph.26.4.207.15871","article-title":"Clinical phenotype and the G11778A mutation of mitochondrial DNA in patients with Leber\u2019s hereditary optic neuropathy in Taiwan.","volume":"26","author":"Chu","year":"2001","journal-title":"Neuro Ophthalmology."},{"key":"B8","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/0022-510x(91)90164-3","article-title":"Hereditary spastic dystonia - 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