{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T07:20:17Z","timestamp":1793690417345,"version":"4.5.1"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T00:00:00Z","timestamp":1659916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Concurrent severe rhabdomyolysis and acute liver damage are rarely reported in the setting of acute high-altitude illness (AHAI). We described a 53-year-old healthy mountain climber who experienced headache and dyspnea at the summit of Snow Mountain (Xueshan; 3,886 m above sea level) and presented to the emergency room with generalized malaise, diffuse muscle pain, and tea-colored urine. His consciousness was alert, and he had a blood pressure of 114\/74 mmHg, heart rate of 66\/min, and body temperature of 36.8\u00b0C. Myalgia of the bilateral lower limbs, diminished skin turgor, dry oral mucosa, and tea-colored urine were notable. Urinalysis showed positive occult blood without red blood cells. The most striking blood laboratory data included creatine kinase (CK) 33,765 IU\/L, inappropriately high aspartate aminotransferase (AST) 2,882 IU\/L and alanine aminotransferase (ALT) 2,259 IU\/L (CK\/AST ratio 11.7, CK\/ALT ratio 14.9), creatinine 1.5 mg\/dl, serum urea nitrogen (BUN) 26 mg\/dl, total bilirubin 1.7 mg\/dl, ammonia 147 \u03bcg\/ml, lactate 2.5 mmol\/L, and prothrombin time 17.8 s. The meticulous search for the underlying causes of acute liver injury was non-revealing. With volume repletion, mannitol use, and urine alkalization coupled with avoidance of nephrotoxic and hepatotoxic agents, his clinical features and laboratory abnormality completely resolved in 3 weeks. Despite rarity, severe rhabdomyolysis and\/oracute liver injury as a potential life-threatening condition requiring urgent management may occur in high-altitude hypobaric hypoxia.<\/jats:p>","DOI":"10.3389\/fmed.2022.917355","type":"journal-article","created":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T05:17:16Z","timestamp":1659935836000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Case report: Severe rhabdomyolysis and acute liver injury in a high-altitude mountain 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