{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:58:14Z","timestamp":1753891094578,"version":"3.41.2"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Subacute thyroiditis, an inflammatory disease, has been reported caused by vaccines in rare cases. In the context of the coronavirus disease 19 pandemic, various SARS-CoV-2 vaccines have been developed and may be potential triggers for subacute thyroiditis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>We report a case of subacute thyroiditis 3 days after receiving the second dose of inactivated SARS-CoV-2 vaccine (BBIBP-CorV). The patient did not report a previous history of thyroid disease, upper respiratory tract infection, or COVID-19. Physical examination, laboratory testing, ultrasonography, and radioactive iodine uptake were consistent with subacute thyroiditis. During follow-up, the patient recovered from symptoms and signs, and imaging changes except for hypothyroidism, requiring an ongoing thyroxine replacement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Inactivated SARS-CoV-2 vaccine may be a causal trigger leading to subacute thyroiditis. Clinicians should be aware of subacute thyroiditis as a possible thyroid-related side effect of an inactivated SARS-CoV-2 vaccine.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2022.918721","type":"journal-article","created":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T04:33:23Z","timestamp":1658550803000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Case Report: Subacute thyroiditis after receiving inactivated SARS-CoV-2 vaccine (BBIBP-CorV)"],"prefix":"10.3389","volume":"9","author":[{"given":"Linhua","family":"Pi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiguang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2345","DOI":"10.1007\/s11154-021-09648-y","article-title":"New aspects in the pathogenesis and management of subacute thyroiditis","volume":"21","author":"Stasiak","year":"2021","journal-title":"Rev Endocr Metab Disord."},{"key":"B2","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/s1607-551x(09)70315-8","article-title":"Subacute thyroiditis following influenza vaccine (Vaxigrip) in a young female","volume":"22","author":"Hsiao","year":"2006","journal-title":"Kaohsiung J Med Sci."},{"key":"B3","first-page":"135","article-title":"Subacute thyroiditis after hepatitis B vaccination","volume":"45","author":"Toft","year":"1998","journal-title":"Endocr J."},{"key":"B4","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1056\/NEJMoa2035389","article-title":"Efficacy and safety of the mRNA-1273 SARS-CoV-2 Vaccine","volume":"384","author":"Baden","year":"2021","journal-title":"N Engl J Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/S1473-3099(20)30831-8","article-title":"Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine, BBIBP-CorV: a randomised, double-blind, placebo-controlled, phase 1\/2 trial","volume":"21","author":"Xia","year":"2021","journal-title":"Lancet Infect Dis."},{"key":"B6","doi-asserted-by":"publisher","first-page":"100689","DOI":"10.1016\/j.eclinm.2020.100689","article-title":"Safety and immunogenicity of INO-4800 DNA vaccine against SARS-CoV-2: A preliminary report of an open-label, Phase 1 clinical trial","volume":"31","author":"Tebas","year":"2021","journal-title":"EClinicalMedicine."},{"key":"B7","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/S0140-6736(20)31604-4","article-title":"Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1\/2, single-blind, randomised controlled trial","volume":"396","author":"Folegatti","year":"2020","journal-title":"Lancet."},{"key":"B8","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/S1473-3099(20)30843-4","article-title":"Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine in healthy adults aged 18-59 years: a randomised, double-blind, placebo-controlled, phase 1\/2 clinical trial","volume":"21","author":"Zhang","year":"2021","journal-title":"Lancet Infect Dis."},{"key":"B9","doi-asserted-by":"publisher","first-page":"737142","DOI":"10.3389\/fmed.2021.737142","article-title":"Case Report: Two cases of subacute thyroiditis following SARS-CoV-2 vaccination","volume":"8","author":"Bornemann","year":"2021","journal-title":"Front Med (Lausanne)."},{"key":"B10","unstructured":"Subacute thyroiditis after mRNA vaccine for COVID-19A956A57\n            FranquemontS\n            GalvezJ\n          35166076J Endocrine Soc.52021"},{"key":"B11","doi-asserted-by":"publisher","first-page":"e16045","DOI":"10.7759\/cureus.16045","article-title":"Subacute Thyroiditis after receiving the adenovirus-vectored vaccine for coronavirus disease (COVID-19)","volume":"13","author":"Oyibo","year":"2021","journal-title":"Cureus."},{"key":"B12","doi-asserted-by":"publisher","first-page":"2600","DOI":"10.1210\/clinem\/dgab373","article-title":"Three cases of subacute thyroiditis following SARS-CoV-2 vaccine: postvaccination ASIA syndrome","volume":"106","author":"Iremli","year":"2021","journal-title":"J Clin Endocrinol Metab."},{"key":"B13","doi-asserted-by":"publisher","first-page":"534","DOI":"10.3390\/jcm9020534","article-title":"Subacute thyroiditis is associated with HLA-B*18:01, -DRB1*01 and -C*04:01-the significance of the new molecular background","volume":"9","author":"Stasiak","year":"2020","journal-title":"J Clin Med"},{"key":"B14","doi-asserted-by":"publisher","first-page":"707726","DOI":"10.3389\/fendo.2021.707726","article-title":"COVID-19-associated subacute thyroiditis: evidence-based data from a systematic review","volume":"12","author":"Trimboli","year":"2021","journal-title":"Front Endocrinol (Lausanne)."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1001\/jama.2021.3199","article-title":"SARS-CoV-2 Vaccines","volume":"325","author":"Creech","year":"2021","journal-title":"JAMA."},{"key":"B16","doi-asserted-by":"publisher","first-page":"2439","DOI":"10.1056\/NEJMoa2027906","article-title":"Safety and immunogenicity of two RNA-Based Covid-19 vaccine candidates","volume":"383","author":"Walsh","year":"2020","journal-title":"N Engl J Med."},{"key":"B17","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1038\/s41586-020-2381-y","article-title":"A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2","volume":"584","author":"Shi","year":"2020","journal-title":"Nature."},{"key":"B18","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1007\/s12026-020-09152-6","article-title":"Molecular mimicry between SARS-CoV-2 spike glycoprotein and mammalian proteomes: implications for the vaccine","volume":"68","author":"Kanduc","year":"2020","journal-title":"Immunol Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"617089","DOI":"10.3389\/fimmu.2020.617089","article-title":"Reaction of human monoclonal antibodies to SARS-CoV-2 proteins with tissue antigens: implications for autoimmune diseases","volume":"11","author":"Vojdani","year":"2020","journal-title":"Front Immunol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"100051","DOI":"10.1016\/j.jtauto.2020.100051","article-title":"Pathogenic priming likely contributes to serious and critical illness and mortality in COVID-19 via autoimmunity","volume":"3","author":"Lyons-Weiler","year":"2020","journal-title":"J Transl Autoimmun."},{"key":"B21","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1007\/s12020-021-02807-w","article-title":"Modulation of ACE-2 mRNA by inflammatory cytokines in human thyroid cells: a pilot study","volume":"74","author":"Coperchini","year":"2021","journal-title":"Endocrine."},{"key":"B22","doi-asserted-by":"publisher","first-page":"150","DOI":"10.3389\/fendo.2016.00150","article-title":"Autoimmune\/inflammatory syndrome induced by adjuvants and thyroid autoimmunity","volume":"7","author":"Watad","year":"2016","journal-title":"Front Endocrinol (Lausanne)."},{"key":"B23","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1080\/21645515.2014.1004026","article-title":"Advances in aluminum hydroxide-based adjuvant research and its mechanism","volume":"11","author":"He","year":"2015","journal-title":"Hum Vaccin Immunother."},{"key":"B24","doi-asserted-by":"publisher","first-page":"101412","DOI":"10.1016\/j.beem.2020.101412","article-title":"syndrome and endocrine autoimmune disorders","volume":"34","author":"Bragazzi","year":"2020","journal-title":"Best Pract Res Clin Endocrinol Metab."},{"key":"B25","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1007\/s40618-022-01767-w","article-title":"SARS-CoV-2 vaccine-associated subacute thyroiditis","volume":"22","author":"Yorulmaz","year":"2022","journal-title":"J Endocrinol Invest."},{"key":"B26","doi-asserted-by":"publisher","first-page":"8952048","DOI":"10.1155\/2021\/8952048","article-title":"A Case report of subacute thyroiditis following mRNA COVID-19 Vaccine","volume":"2021","author":"Plaza-Enriquez","year":"2021","journal-title":"Case Rep Endocrinol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1007\/s40618-021-01681-7","article-title":"Post-COVID-vaccine autoimmune\/inflammatory syndrome in response to adjuvants (ASIA syndrome) manifesting as subacute thyroiditis","volume":"45","author":"Das","year":"2022","journal-title":"J Endocrinol Invest."},{"key":"B28","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1007\/s40618-021-01707-0","article-title":"Thyroid as a target of adjuvant autoimmunity\/inflammatory syndrome due to mRNA-based SARS-CoV2 vaccination: from Graves' disease to silent thyroiditis","volume":"45","author":"Pujol","year":"2022","journal-title":"J Endocrinol Invest."},{"key":"B29","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1056\/NEJMra2035343","article-title":"Maintaining Safety with SARS-CoV-2 Vaccines","volume":"384","author":"Castells","year":"2021","journal-title":"N Engl J Med."},{"key":"B30","doi-asserted-by":"publisher","first-page":"24711","DOI":"10.1136\/bcr-2021-244711","article-title":"Subacute thyroiditis after inactive SARS-CoV-2 vaccine","volume":"14","author":"Saygili","year":"2021","journal-title":"BMJ Case Rep"},{"key":"B31","doi-asserted-by":"publisher","first-page":"100136","DOI":"10.1016\/j.metop.2021.100136","article-title":"Thyroiditis following vaccination against COVID-19: Report of two cases and review of the literature","volume":"12","author":"Siolos","year":"2021","journal-title":"Metabol Open."},{"key":"B32","doi-asserted-by":"publisher","first-page":"23247096211043386","DOI":"10.1177\/23247096211043386","article-title":"A Case of hypophysitis following immunization with the mRNA-1273 SARS-CoV-2 vaccine","volume":"9","author":"Murvelashvili","year":"2021","journal-title":"J Investig Med High Impact Case Rep."},{"key":"B33","doi-asserted-by":"publisher","first-page":"102710","DOI":"10.1016\/j.jaut.2021.102710","article-title":"Autoimmune hepatitis triggered by SARS-CoV-2 vaccination","volume":"123","author":"Vuille-Lessard","year":"2021","journal-title":"J Autoimmun."},{"key":"B34","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1016\/j.kint.2021.06.033","article-title":"Granulomatous vasculitis after the AstraZeneca anti-SARS-CoV-2 vaccine","volume":"100","author":"Gillion","year":"2021","journal-title":"Kidney Int."},{"key":"B35","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1111\/bjh.17508","article-title":"Immune thrombocytopenic purpura after SARS-CoV-2 vaccine","volume":"194","author":"Candelli","year":"2021","journal-title":"Br J Haematol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1056\/NEJMc2109975","article-title":"Myocarditis after COVID-19 mRNA vaccination","volume":"385","author":"Verma","year":"2021","journal-title":"N Engl J Med."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2022.918721\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T04:33:29Z","timestamp":1658550809000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2022.918721\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,22]]},"references-count":36,"alternative-id":["10.3389\/fmed.2022.918721"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2022.918721","relation":{},"ISSN":["2296-858X"],"issn-type":[{"type":"electronic","value":"2296-858X"}],"subject":[],"published":{"date-parts":[[2022,7,22]]},"article-number":"918721"}}