{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:00:23Z","timestamp":1753891223522,"version":"3.41.2"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T00:00:00Z","timestamp":1655424000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>We aim to establish an objective and accurate prediction model by evaluating the uterine cavity and correlate these key factors with the live birth rate after hysteroscopic adhesiolysis (HA). A total of 457 intrauterine adhesions (IUA) patients were retrospectively enrolled in this study. The participants underwent HA and second-look hysteroscopy at the Third Xiangya Hospital of Central South University. Pregnancy outcomes, including spontaneous live births and no live births (miscarriages and infertility), were followed. Clinical parameters, containing the number of visible uterine horns and tubal ostia, the length of the uterine cavity, among others, were measured and analyzed to determine the dominant variables in an attempt to establish the live birth rate, prediction models. Women in the no live birth group were older than that in the live birth group (<jats:italic>P<\/jats:italic> = 0.0002, OR = 0.895, 95% CI: 0.844\u20130.949) and were more likely to be 2 gravidity (<jats:italic>P<\/jats:italic> = 0.0136, OR = 2.558, 95% CI: 1.213\u20135.394). Uterine cavity length in pre-HA hysteroscopy was longer in the live birth group (<jats:italic>P<\/jats:italic> = 0.0018, OR = 1.735, 95% CI: 1.227\u20132.453), and adhesion scores in pre-HA hysteroscopy were more frequently above 6 (<jats:italic>P<\/jats:italic> = 0.0252, OR = 0.286, 95% CI: 0.096\u20130.856) in the no live birth group. During the second-look, hysteroscopy, visible bilateral fallopian tube ostia were more frequently observed in the live birth group (<jats:italic>P<\/jats:italic> = 0.0339, OR = 11.76, 95% CI: 1.207\u2013114.611), and adhesion scores were 4\u20136 (<jats:italic>P<\/jats:italic> &amp;lt; 0.0001, OR = 0.032, 95% CI: 0.007\u20130.146) and above 6 (<jats:italic>P<\/jats:italic> &amp;lt; 0.0001, OR = 0.012, 95% CI: 0.002\u20130.073) in the no live birth group. The areas under the curves (AUCs) of the pre-HA and second-look hysteroscopy prediction models were 0.7552 and 0.8484, respectively. We established an objective and accurate method for evaluating the uterine cavity by hysteroscopy, and second-look hysteroscopy is more valuable than the fist hysteroscopy in predicting the live birth rate following HA. Visible bilateral fallopian tube ostia or adhesion scores were &amp;lt;4 in the second-look hysteroscopy might predict live birth after surgery.<\/jats:p>","DOI":"10.3389\/fmed.2022.926754","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T05:59:46Z","timestamp":1655445586000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Uterine Cavity Parameters Evaluated by Hysteroscopy can Predict the Live Birth Rate For Intrauterine Adhesion Patients"],"prefix":"10.3389","volume":"9","author":[{"given":"Xingping","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiqian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuting","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuijing","family":"Yi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dabao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/j.fertnstert.2008.02.096","article-title":"Asherman 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