{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T10:42:26Z","timestamp":1783939346900,"version":"3.55.0"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Talaromyces marneffei<\/jats:italic> (<jats:italic>T<\/jats:italic>. <jats:italic>marneffei<\/jats:italic>) is an opportunistic fungal pathogen commonly found in human immunodeficiency virus (HIV) patients that often infects lymph nodes. Knowledge about the computed tomography (CT) characteristics of <jats:italic>T<\/jats:italic>. <jats:italic>marneffei<\/jats:italic> lymphadenopathy in HIV patients is limited. The aim of this study was to investigate the clinical and CT characteristics of <jats:italic>T<\/jats:italic>. <jats:italic>marneffei<\/jats:italic> lymphadenopathy to improve its diagnosis and promote recognition of this type of infection in radiology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between February 2019 and June 2021, we retrospectively reviewed the clinical features and CT characteristics of <jats:italic>T<\/jats:italic>. <jats:italic>marneffei<\/jats:italic> lymphadenopathy in 21 HIV patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The clinical symptoms of <jats:italic>T<\/jats:italic>. <jats:italic>marneffei<\/jats:italic> infection are non-specific. Anemia (100%), fever (85.7%) and cough and sputum production (76.2%) were the most frequent symptoms. Multiple lymphadenopathies, mainly in the mediastinum (76.2%) and mesentery (82.4%), can be fused (14.3%) and necrotic (52.4%), with slight (41.7%) and moderate enhancement (58.3%) that is heterogeneous. In addition to involving the lymph nodes, the lesions involved the lungs (81.0%), liver and spleen (42.9%), and small intestine (14.3%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>T<\/jats:italic>. <jats:italic>marneffei<\/jats:italic> is prone to affecting lymph nodes and extranodal organs in HIV patients. Although the clinical manifestations of <jats:italic>T<\/jats:italic>. <jats:italic>marneffei<\/jats:italic> infection are not specific, the possibility of <jats:italic>T. marneffei<\/jats:italic> infection should be considered if CT findings indicate multiple lesion sites.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2022.930678","type":"journal-article","created":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T05:29:55Z","timestamp":1658899795000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["CT findings of Talaromyces marneffei infection among HIV patients with 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