{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:37:29Z","timestamp":1780447049076,"version":"3.54.1"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:00:00Z","timestamp":1666310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The prognostic impact of marital status on malignant pleural mesothelioma (MPM) is not investigated. This paper probes into the relationship between the prognosis of MPM and marital status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>The Surveillance, Epidemiology, and End Results (SEER) database of American had been applied to choose eligible patients over the 2004\u20132015 periods. Moreover, cancer-specific survival (CSS) and overall survival (OS) of unmarried and married groups were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 3,997 patients in total had been identified, including 2,735 (68.43%) married patients. In comparison to unmarried patients, married ones tended to be younger, male, white, and received active treatment (surgery, chemotherapy, or radiotherapy). In addition, the 1, 3, and 5-year CSS rates were 44.40, 12.09, and 6.88% in married patients, while 35.75, 12.12, and 6.37% in unmarried group (<jats:italic>p<\/jats:italic> = 0.0014). At the same time, the 1, 3, and 5-year OS rates were 41.84, 10.56, and 5.91% in married patients, while 33.67, 10.44, and 4.93%, respectively, in the unmarried group (<jats:italic>p<\/jats:italic> &amp;lt; 0.0001). As revealed by the multivariate analysis results, the marital status was an independent favorable prognostic factor, in which the married groups showed better CSS [hazard ratio (<jats:italic>HR<\/jats:italic>): 0.870; 95% confidence interval (<jats:italic>CI<\/jats:italic>): 0.808\u20130.938; <jats:italic>p<\/jats:italic> &amp;lt; 0.001] as well as OS (<jats:italic>HR<\/jats:italic>: 0.871; 95% <jats:italic>CI<\/jats:italic>: 0.810\u20130.936; <jats:italic>p<\/jats:italic> &amp;lt; 0.001). According to the results of subgroup analysis, the CSS and <jats:italic>OS<\/jats:italic> survival of married groups were better than the unmarried groups in almost all the subgroups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Marital status is an independent favorable prognostic indicator of MPM. Poor prognosis in unmarried patients is likely to be related to insufficient treatments and socioeconomic and psychosocial factors.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2022.955619","type":"journal-article","created":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T05:08:41Z","timestamp":1666328921000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Marital status as an independent prognostic factor for patients of malignant pleural 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