{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T03:12:22Z","timestamp":1777605142516,"version":"3.51.4"},"reference-count":17,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T00:00:00Z","timestamp":1657756800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>This case report describes a 58-year-old, never-smoking housewife with chief complaints of progressively worsening cough, dyspnea, and intermittent fever, who was initially misdiagnosed with community-acquired pneumonia (CAP). However, her pulse oximetry oxygen saturation continued to decline, and eventually, she underwent an endotracheal intubation. Fortunately, transbronchial cryobiopsy (TBCB) assisted by extracorporeal membrane oxygenation (ECMO) was performed in the most critical situation, and it revealed an organizing pneumonia (OP) pattern. OP describes a histological pattern of acute or subacute pulmonary damage, which may be idiopathic or associated with a known or unknown underlying disease. A definitive diagnosis of OP usually obtained from pathology, and surgical lung biopsy with large lung tissue is recommended. However, since the surgical lung biopsy was not convenient for this patient after mechanical ventilation, bedside TBCB supported by ECMO was selected. To our knowledge, we are the first to report the pathological diagnosis of ECMO assisted TBCB in acute respiratory failure. When oxygenation cannot be maintained after endotracheal intubation and surgical lung biopsy is not feasible, ECMO-supported TBCB may be a good choice to obtain lung tissue for histopathological diagnosis in patients with acute lung injury of unknown etiology.<\/jats:p>","DOI":"10.3389\/fmed.2022.955992","type":"journal-article","created":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T05:06:46Z","timestamp":1657775206000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Extracorporeal Membrane Oxygenation Supported Transbronchial Cryobiopsy in the Diagnosis of Severe Organizing Pneumonia: A Case Report"],"prefix":"10.3389","volume":"9","author":[{"given":"Xiaoyan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqiong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingying","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunxia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanbo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Xing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenlin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingyuan","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,7,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr.03.2009.1689","article-title":"Organising pneumonia presenting as acute life threatening pulmonary haemorrhage.","volume":"2011","author":"Narasimhaiah","year":"2011","journal-title":"BMJ Case Rep."},{"key":"B2","doi-asserted-by":"publisher","first-page":"829","DOI":"10.3892\/etm.2015.2183","article-title":"Macrolide therapy in cryptogenic organizing pneumonia: a case report and literature review.","volume":"9","author":"Ding","year":"2015","journal-title":"Exp Ther Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.ejrad.2013.04.017","article-title":"CT features of focal organizing pneumonia: an analysis of consecutive histopathologically confirmed 45 cases.","volume":"83","author":"Zhao","year":"2014","journal-title":"Eur J Radiol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"v1","DOI":"10.1136\/thx.2008.101691","article-title":"Interstitial lung disease guideline: the British thoracic society in collaboration with the thoracic society of Australia and New Zealand and the Irish thoracic society.","volume":"63","author":"Bradley","year":"2008","journal-title":"Thorax."},{"key":"B5","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1055\/s-0032-1325157","article-title":"Cryptogenic organizing pneumonia.","volume":"33","author":"Cottin","year":"2012","journal-title":"Semin Respir Crit Care Med."},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-018-0764-8","article-title":"Predictive factors for relapse of cryptogenic organizing pneumonia.","volume":"19","author":"Saito","year":"2019","journal-title":"BMC Pulm Med."},{"key":"B7","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1183\/09031936.06.00013505","article-title":"Cryptogenic organising pneumonia.","volume":"28","author":"Cordier","year":"2006","journal-title":"Eur Respir J."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1177\/0300060520920068","article-title":"Findings on cryptogenic organizing pneumonia: a case report and literature review.","volume":"48","author":"Yao","year":"2020","journal-title":"J Int Med Res."},{"key":"B9","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1056\/NEJM198501173120304","article-title":"Bronchiolitis obliterans organizing pneumonia.","volume":"312","author":"Epler","year":"1985","journal-title":"New Engl J Med."},{"key":"B10","doi-asserted-by":"crossref","first-page":"8S","DOI":"10.1378\/chest.102.1.8S","article-title":"Cryptogenic organizing pneumonitis. 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