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Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Little is known about the association of comorbidities with sex and age at diagnosis in Sj\u00f6gren's disease. We tested the hypothesis that sex differences occur in comorbidities in patients with Sj\u00f6gren's disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with Sj\u00f6gren's disease were identified from 11\/1974 to 7\/2018 in the Mayo Clinic electronic medical record and assessed for 22 comorbidities according to sex and age at diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 13,849 patients identified with Sj\u00f6gren's disease, 11,969 (86%) were women and 1,880 (14%) men, primarily white (88%) with a sex ratio of 6.4:1 women to men. The mean age at diagnosis was 57 years for women and 59.7 years for men, and 5.6% had a diagnosis of fibromyalgia at Sj\u00f6gren's diagnosis. Men with Sj\u00f6gren's disease were more likely than women to be a current or past smoker. The average time to diagnosis of comorbidities after diagnosis of Sj\u00f6gren's disease was 2.6 years. The top comorbidities in patients with Sj\u00f6gren's disease were fibromyalgia (25%), depression (21.2%) and pain (16.4%). Comorbidities that occurred more often in women were hypermobile syndromes (31:1), CREST (29:1), migraine (23:1), Ehlers-Danlos syndrome (EDS) (22:1), Raynaud's syndrome (15:1), SLE (13:1), systemic sclerosis (SSc) (13:1), and fibromyalgia (12:1). Women with Sj\u00f6gren's disease were at increased risk of developing hypermobile syndromes (RR 7.27, CI 1.00\u201352.71, <jats:italic>p<\/jats:italic> = 0.05), EDS (RR 4.43, CI 1.08\u201318.14, <jats:italic>p<\/jats:italic> = 0.039), CREST (RR 4.24, CI 1.56\u201311.50, <jats:italic>p<\/jats:italic> = 0.005), migraine (RR 3.67, CI 2.39\u20135.62, <jats:italic>p<\/jats:italic> &amp;lt; 0.001), fibromyalgia (RR 2.26, CI 1.92\u20132.66, <jats:italic>p<\/jats:italic> &amp;lt; 0.001), Raynaud's syndrome (RR 2.29, CI 1.77\u20132.96, <jats:italic>p<\/jats:italic> &amp;lt; 0.001), SLE (RR 2.13, CI 1.64\u20132.76, <jats:italic>p<\/jats:italic> &amp;lt; 0.001), and SSc (RR 2.05 CI 1.44\u20132.92; <jats:italic>p<\/jats:italic> &amp;lt; 0.001). In contrast, men with Sj\u00f6gren's were at increased risk for developing myocardial infarction (RR 0.44, CI 0.35\u20130.55, <jats:italic>p<\/jats:italic> &amp;lt; 0.001), atherosclerosis\/CAD (RR 0.44, CI 0.39\u20130.49, <jats:italic>p<\/jats:italic> &amp;lt; 0.001), cardiomyopathy (RR 0.63, CI 0.46\u20130.86, <jats:italic>p<\/jats:italic> = 0.003), stroke (RR 0.66 CI 0.51\u20130.85, <jats:italic>p<\/jats:italic> = 0.001), and congestive heart failure (RR 0.70, CI 0.57\u20130.85, <jats:italic>p<\/jats:italic> &amp;lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The top comorbidities in Sj\u00f6gren's disease were fibromyalgia, depression, and pain. Women with Sj\u00f6gren's disease had a higher relative risk of developing fibromyalgia, depression, pain, migraine, hypermobile syndrome, EDS and other rheumatic autoimmune diseases. Men with Sj\u00f6gren's disease had higher risk of developing cardiovascular diseases.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2022.958670","type":"journal-article","created":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T04:37:20Z","timestamp":1659587840000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Sex differences in comorbidities associated with Sj\u00f6gren's disease"],"prefix":"10.3389","volume":"9","author":[{"given":"Katelyn A.","family":"Bruno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Carolina","family":"Morales-Lara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edsel 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