{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:28:58Z","timestamp":1790677738254,"version":"4.1.0"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T00:00:00Z","timestamp":1660003200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Refractory septic shock (RSS) is characterized by high vasopressor requirements, as a consequence of vasopressor resistance, which may be caused or enhanced by sympathetic hyperactivation. Experimental models and clinical trials show a reduction in vasopressor requirements and improved microcirculation compared to conventional sedation. Dexmedetomidine did not reduce mortality in clinical trials, but few septic shock patients were enrolled. This pilot trial aims to evaluate vasopressor re-sensitization with dexmedetomidine and assess the effect size, in order to design a larger trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is an investigator-initiated, multicenter, randomized, double-blind, placebo-controlled trial, comparing dexmedetomidine versus placebo in RSS patients with norepinephrine dose \u22650.5\u03bcg\/kg\/min. The primary outcome is blood pressure response to phenylephrine challenge, 6 hours after completion of a first challenge, after study treatment initiation. Secondary outcomes include feasibility and safety outcomes (bradycardia), mortality, vasopressor requirements, heart rate variability, plasma and urine catecholamines levels. The sample size is estimated at 32 patients to show a 20% improvement in blood pressure response to phenylephrine. Randomization (1:1) will be stratified by center, sedation type and presence of liver cirrhosis. Blood pressure and ECG will be continuously recorded for the first 24 h, enabling high-quality data collection for the primary and secondary endpoints. The study was approved by the ethics committee \u201cSud-Est VI\u201d (2019-000726-22) and patients will be included after informed consent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The present study will be the first randomized trial to specifically address the hemodynamic effects of dexmedetomidine in patients with septic shock. We implement a high-quality process for data acquisition and recording in the first 24 h, ensuring maximal quality for the evaluation of both efficacy and safety outcomes, as well as transparency of results. The results of the study will be used to elaborate a full-scale randomized controlled trial with mortality as primary outcome in RSS patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial registration<\/jats:title><jats:p>Registered with ClinicalTrials.gov (NCT03953677). Registered 16 May 2019, <jats:ext-link>https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03953677<\/jats:ext-link>.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2022.968274","type":"journal-article","created":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T05:19:31Z","timestamp":1660022371000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Dexmedetomidine to reduce vasopressor resistance in refractory septic shock: Protocol for a double-blind randomized controlled pilot trial (ADRESS Pilot study)"],"prefix":"10.3389","volume":"9","author":[{"given":"Auguste","family":"Dargent","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abderrahmane","family":"Bourredjem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Argaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Levy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Fournel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lie","family":"Cransac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Badie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Quintin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Quenot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s13613-015-0058-8","article-title":"Timing and causes of death in septic shock","volume":"5","author":"Daviaud","year":"2015","journal-title":"Ann Intens Care."},{"key":"B2","doi-asserted-by":"publisher","first-page":"R65","DOI":"10.1186\/cc12598","article-title":"The epidemiology of septic shock in French intensive care units: the prospective multicenter cohort EPISS study","volume":"17","author":"Quenot","year":"2013","journal-title":"Crit Care."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.1378\/chest.113.6.1640","article-title":"Effect of L-NAME, an inhibitor of nitric oxide synthesis, on cardiopulmonary function in human septic shock","volume":"113","author":"Avontuur","year":"1998","journal-title":"Chest."},{"key":"B4","doi-asserted-by":"publisher","first-page":"104","DOI":"10.5754\/hge10550","article-title":"Terlipressin in the treatment of late phase catecholamine-resistant septic shock","volume":"59","author":"Svoboda","year":"2012","journal-title":"Hepato-gastroenterology."},{"key":"B5","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s13613-017-0261-x","article-title":"Outcome of patients with septic shock and high-dose vasopressor therapy","volume":"7","author":"Auchet","year":"2017","journal-title":"Ann Intens Care."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/SHK.0000000000001022","article-title":"Group and the E study. 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