{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:31:23Z","timestamp":1790623883627,"version":"4.1.0"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T00:00:00Z","timestamp":1663891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>To overcome resistance to chemotherapy for colorectal cancer, we propose to validate <jats:italic>in vivo<\/jats:italic> a novel terpyridine-platinum (TP) compound radiolabeled with the radio-theranostic isotope <jats:sup>64<\/jats:sup>Cu. <jats:italic>In vivo<\/jats:italic> stability, biodistribution, PET imaging, tumor growth delay, toxicity and dosimetry of [<jats:sup>64<\/jats:sup>Cu]NOTA-C3-TP were determined. The current experimental studies show that [<jats:sup>64<\/jats:sup>Cu]NOTA-C3-TP is stable <jats:italic>in vivo<\/jats:italic>, rapidly eliminated by the kidneys and has a promising tumor uptake ranging from 1.8 \u00b1 0.4 to 3.0 \u00b1 0.2 %ID\/g over 48 h. [<jats:sup>64<\/jats:sup>Cu]NOTA-C3-TP retarded tumor growth by up to 6 \u00b1 2.0 days and improved survival relative to vehicle and non-radioactive [<jats:sup>Nat<\/jats:sup>Cu]NOTA-C3-TP over 17 days of tumor growth observation. This effect was obtained with only 0.4 nmol <jats:italic>i.v<\/jats:italic>. injection of [<jats:sup>64<\/jats:sup>Cu]NOTA-C3-TP, which delivers 3.4 \u00b1 0.3 Gy tumoral absorbed dose. No evidence of toxicity, by weight loss or mortality was revealed. These findings confirm the high potential of [<jats:sup>64<\/jats:sup>Cu]NOTA-TP as a novel radio-theranostic agent.<\/jats:p>","DOI":"10.3389\/fmed.2022.975213","type":"journal-article","created":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T08:47:10Z","timestamp":1663922830000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["In vivo behavior of [64Cu]NOTA-terpyridine platinum, a novel chemo-radio-theranostic agent for imaging, and therapy of colorectal cancer"],"prefix":"10.3389","volume":"9","author":[{"given":"Meysam","family":"Khosravifarsani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samia","family":"Ait-Mohand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benoit","family":"Paquette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9on","family":"Sanche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Gu\u00e9rin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"89","DOI":"10.5114\/pg.2018.81072","article-title":"Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors","volume":"14","author":"Rawla","year":"2019","journal-title":"Prz Gastroenterol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"31","DOI":"10.3390\/medsci6020031","article-title":"Colorectal cancer: genetic abnormalities, tumor progression, tumor heterogeneity, clonal evolution and tumor-initiating cells","volume":"6","author":"Testa","year":"2018","journal-title":"Med Sci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"676","DOI":"10.3390\/cancers5020676","article-title":"Epigenetics and colorectal cancer pathogenesis","volume":"5","author":"Bardhan","year":"2013","journal-title":"Cancers."},{"key":"B4","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1097\/DCR.0000000000000926","article-title":"The american society of colon and rectal surgeons clinical practice guidelines for the treatment of colon cancer","volume":"60","author":"Vogel","year":"2017","journal-title":"Dis Colon Rectum."},{"key":"B5","doi-asserted-by":"publisher","first-page":"15065","DOI":"10.1038\/nrdp.2015.65","article-title":"Colorectal cancer","volume":"1","author":"Kuipers","year":"2015","journal-title":"Nat Rev Dis Primers."},{"key":"B6","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1007\/s11864-015-0348-2","article-title":"Microsatellite instability testing and its role in the management of colorectal cancer","volume":"16","author":"Kawakami","year":"2015","journal-title":"Curr Treat Options Oncol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1177\/1758834015614530","article-title":"Swaika A, Mody K. 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