{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:47:55Z","timestamp":1775868475399,"version":"3.50.1"},"reference-count":14,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T00:00:00Z","timestamp":1661385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014175","name":"Shanghai Municipal Health and Family Planning Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014175","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Green nail syndrome (GNS) is a triad of green discoloration of the nail plate, proximal paronychia, and distal onycholysis. <jats:italic>Pseudomonas aeruginosa<\/jats:italic> is known to be the most common causative agent; however, there is no unified standard for the diagnosis and treatment of GNS. Thus, treatment is challenging and often refractory. Here, we report three representative cases with different predisposing factors, including trauma-related, occupation-related, and onychosis-related GNS. Patients with GNS accompanied by onycholysis were instructed to undergo chemical nail avulsion combined with topical antibiotics, and favorable curative effects were observed in all cases. Chemical nail avulsion with urea powder as a conventional method may be an effective treatment for GNS and warrants clinical generalization.<\/jats:p>","DOI":"10.3389\/fmed.2022.991918","type":"journal-article","created":{"date-parts":[[2022,9,22]],"date-time":"2022-09-22T15:57:47Z","timestamp":1663862267000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Case report: Novel use of the conventional method- chemical nail avulsion may be effective for treatment of green nail syndrome"],"prefix":"10.3389","volume":"9","author":[{"given":"Qian","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianjuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/j.jaad.2020.06.087","article-title":"Appending the appendages: new perspectives on netherton syndrome and green nail syndrome.","volume":"83","author":"Heymann","year":"2020","journal-title":"J Am Acad Dermatol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/s00105-013-2704-0","article-title":"Infections of finger and toe nails due to fungi and bacteria.","volume":"65","author":"Nenoff","year":"2014","journal-title":"Hautarzt."},{"key":"B3","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1097\/QCO.0000000000000717","article-title":"Skin manifestations of Pseudomonas aeruginosa infections.","volume":"34","author":"Spernovasilis","year":"2021","journal-title":"Curr Opin Infect Dis."},{"key":"B4","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1007\/s40257-019-00476-0","article-title":"Retrospective case series on risk factors, diagnosis and treatment of Pseudomonas aeruginosa nail infections.","volume":"21","author":"Geizhals","year":"2020","journal-title":"Am J Clin Dermatol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1016\/j.jaad.2020.01.040","article-title":"Green nail syndrome: analysis of the association with onychomycosis.","volume":"83","author":"Ohn","year":"2020","journal-title":"J Am Acad Dermatol."},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMicm0706497","article-title":"Images in clinical medicine. 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