{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:25:44Z","timestamp":1791890744327,"version":"4.3.4"},"reference-count":17,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:00:00Z","timestamp":1670198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study analyses the 2020 survey and reviews the 2009, 2014 surveys to ascertain which Beh\u00e7et's symptoms, personal and family status, patients' lifestyle, and work-related outcomes impacted on Health-Related Quality of Life (HRQoL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Four hundred and fifty-nine Beh\u00e7et's patients submitted an online survey\/questionnaire. Patients provided information on socio-demographic characteristics, disease duration, historical and current symptoms, systemic and topical medication, health related lifestyle, work-related outcomes regarding employment status and claiming benefits and Quality of Life (QoL) measured by EQ-5D index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four hundred and nineteen patients met the inclusion criteria, and 371 who had full data (Males: Females: Others = 84:285:2, mean\u2013age = 41.1 \u00b1 23.3:38 \u00b1 13.2:40 \u00b1 5). The main symptoms associated with patients seeking medical care were mouth ulcers 30% and genital ulcers 23%, joint 14%, and eye problems 9%. The EQ-5D index for 2009, 2014, 2020 was (mean \u00b1 SD); 0.47 \u00b1 0.38, 0.42 \u00b1 0.37, 0.34 \u00b1 0.40, respectively, <jats:italic>p<\/jats:italic> &amp;lt; 0.05. 2020 patients had the worst values of the five domains compared to 2014 and 2009. Interestingly, mobility value was the same over the 10 years of monitoring patients. Beh\u00e7et's syndrome (BS) symptoms that had significant negative impact on QoL were; 2009 (arthropathy, neurological problems, pathergy reaction, and stomach\/bowel symptoms), 2014 (arthropathy, headache, neurological problems, pathergy reaction, and skin lesions), 2020 (arthropathy, neurological problems, and stomach\/bowel symptoms). The 2014 and 2020 surveys reported the QoL is significantly better in patients on immunosuppressant, who did sport, continued in employment and not receiving benefits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Joints and neurological symptoms are the main symptoms which had negative impact on BS patients over the 10 years, sociodemographic (gender, age, marital, and education status), lifestyle (medication, cannabis, drinking wine, and regular exercise), employment status (employee and no career change), and accessing benefits (never claim benefit) had significant influence on patients' HRQoL.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2022.996571","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T06:56:30Z","timestamp":1670223390000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["The impact of multifactorial factors on the Quality of Life of Beh\u00e7et's patients over 10 years"],"prefix":"10.3389","volume":"9","author":[{"given":"Amal A.","family":"Senusi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Mather","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Ola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley A.","family":"Bergmeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bindi","family":"Gokani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farida","family":"Fortune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,12,5]]},"reference":[{"key":"B1","first-page":"931","article-title":"Development of the BD-QoL: a quality of life measure specific to Beh\u00e7et's disease","volume":"31","author":"Gilworth","year":"2004","journal-title":"J Rheumatol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/s10067-005-0046-8","article-title":"Quality of life and life satisfaction in patients with Beh\u00e7et's disease: relationship with disease activity","volume":"25","author":"Bodur","year":"2006","journal-title":"Clin Rheumatol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1111\/j.1601-0825.2005.01173.x","article-title":"Oral health related quality of life is affected by disease activity in Beh\u00e7et's disease","volume":"12","author":"Mumcu","year":"2006","journal-title":"Oral Dis."},{"key":"B4","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/s13023-015-0341-7","article-title":"Genital ulcer severity score and genital health quality of life in Beh\u00e7et's disease","volume":"10","author":"Senusi","year":"2015","journal-title":"Orphanet J Rare Dis"},{"key":"B5","first-page":"S18","article-title":"Quality of life and its relation with disease severity in Beh\u00e7et's disease","volume":"27","author":"Ertam","year":"2009","journal-title":"Clin Exp Rheumatol"},{"key":"B6","first-page":"S110","article-title":"Beh\u00e7et's syndrome patients have high levels of functional disability, fatigue and pain as measured by a Multi-dimensional Health Assessment Questionnaire (MDHAQ)","volume":"4","author":"Alder","year":"2008","journal-title":"Clin Exp Rheumatol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"2165","DOI":"10.1093\/rheumatology\/keq251","article-title":"Impact of Beh\u00e7et's syndrome on health-related quality of life: influence of the type and number of symptoms","volume":"49","author":"Bernab\u00e9","year":"2010","journal-title":"Rheumatology"},{"key":"B8","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s10654-006-9092-z","article-title":"Health-related quality of life as a predictor of mortality among community-dwelling older persons","volume":"22","author":"Tsai","year":"2007","journal-title":"Eur J Epidemiol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.2105\/AJPH.2007.114041","article-title":"Prospective change in health-related quality of life and subsequent mortality among middle-aged and older women","volume":"98","author":"Kroenke","year":"2008","journal-title":"Amer J Publ Health"},{"key":"B10","first-page":"373","article-title":"World Medical Association Declaration of Helsinki. 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