{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:06:10Z","timestamp":1753891570915,"version":"3.41.2"},"reference-count":12,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T00:00:00Z","timestamp":1674691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Uterine collision tumor is a rare pathological type composed of two or more malignant tumors. The components of these malignant tumors do not have histological mixing and are separated by the normal mesenchyme. Collision cancer is very rare, with uterine collision tumors being even rarer. Only a few cases have been reported in relation to uterine collision tumors. At present, there is no standard treatment guideline for uterine collision tumors, and a comprehensive treatment composed of surgery, radiotherapy, and chemotherapy is suggested. In this study, we report a 54-year-old female patient diagnosed with highly differentiated endometrial adenocarcinoma with cervical carcinosarcoma. The endometrial adenocarcinoma component invaded the deep myometrium (&amp;gt; 1\/2 layer), involving the cervical glands and interstitium. The regional lymph node metastasis from endometrial adenocarcinoma was also detected. The patient underwent \u201ctransabdominal tumor cytoreduction (total hysterectomy + right adnexal resection + greater omentectomy + pelvic lymph node dissection + para-aortic lymph node dissection) + pelvic adhesion release.\u201d In addition, she has completed adjuvant radiotherapy and chemotherapy. After reviewing previous reports of collision tumors in different positions of the uterus, we found that collision tumors between the cervix and uterine body are very uncommon. In addition, we have not found any reports on the metastasis of sarcoid components, no matter what the composition is.<\/jats:p>","DOI":"10.3389\/fmed.2023.1044196","type":"journal-article","created":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T10:55:19Z","timestamp":1674730519000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Case report: Highly differentiated endometrial adenocarcinoma that collided with uterine cervical carcinosarcoma"],"prefix":"10.3389","volume":"10","author":[{"given":"Xue","family":"Fan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haoyue","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songtao","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,26]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1634\/theoncologist.2013-0445","article-title":"Progestins in the fertility-sparing treatment and retreatment of patients with primary and recurrent endometrial cancer.","volume":"20","author":"Park","year":"2015","journal-title":"Oncologist."},{"key":"B2","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J Clin."},{"key":"B3","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1146\/annurev-pathol-020117-043609","article-title":"Molecular genetics of endometrial carcinoma.","volume":"14","author":"Bell","year":"2019","journal-title":"Annu Rev Pathol."},{"key":"B4","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.ygyno.2005.06.021","article-title":"Cervical sarcomas: an analysis of incidence and outcome.","volume":"99","author":"Wright","year":"2005","journal-title":"Gynecol Oncol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1177\/10668969211037915","article-title":"Two components of variant profiles in primary vaginal carcinosarcoma via next-generation sequencing and a literature review.","volume":"30","author":"Kotoku","year":"2022","journal-title":"Int J Surgic Pathol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"89","DOI":"10.3346\/jkms.2012.27.1.89","article-title":"Collision of three histologically distinct endometrial cancers of the uterus.","volume":"27","author":"Jang","year":"2012","journal-title":"J Korean Med Sci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1046\/j.1440-1827.2003.01467.x","article-title":"Hepatoid carcinoma of the uterus that collided with carcinosarcoma.","volume":"53","author":"Takahashi","year":"2003","journal-title":"Pathol Int."},{"key":"B8","doi-asserted-by":"publisher","first-page":"802","DOI":"10.4103\/IJPM.IJPM_701_20","article-title":"Uterine collision tumor of endometrial stromal sarcoma and endometrioid adenocarcinoma: a rare case report and review of literature.","volume":"64","author":"Sharma","year":"2021","journal-title":"Indian J Pathol Microbiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1097\/00004347-200007000-00005","article-title":"Comparison of the genetic alterations in two epithelial collision tumors of the uterine cervix. A report of two cases.","volume":"19","author":"Kersemaekers","year":"2000","journal-title":"Int J Gynecol Pathol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"ED20","DOI":"10.7860\/JCDR\/2017\/23532.9405","article-title":"A rare collision tumour of uterus- squamous cell carcinoma and endometrial stromal sarcoma.","volume":"11","author":"Tanveer","year":"2017","journal-title":"J Clin Diagn Res."},{"key":"B11","doi-asserted-by":"publisher","first-page":"163","DOI":"10.4132\/jptm.2013.11.25","article-title":"Serous cystadenoma and fibrothecoma: a rare combination in collision tumor of ovary with pseudo-meigs syndrome.","volume":"49","author":"Chandanwale","year":"2015","journal-title":"J Pathol Transl Med."},{"key":"B12","doi-asserted-by":"publisher","first-page":"563","DOI":"10.3892\/mco.2016.770","article-title":"Three histologically distinct cancers of the uterine corpus: a case report and review of the literature.","volume":"4","author":"Masuyama","year":"2016","journal-title":"Mol Clin Oncol."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2023.1044196\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T10:55:25Z","timestamp":1674730525000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2023.1044196\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,26]]},"references-count":12,"alternative-id":["10.3389\/fmed.2023.1044196"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2023.1044196","relation":{},"ISSN":["2296-858X"],"issn-type":[{"type":"electronic","value":"2296-858X"}],"subject":[],"published":{"date-parts":[[2023,1,26]]},"article-number":"1044196"}}