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Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Joint pain is a common symptom in patients with hypermobile Ehlers-Danlos Syndrome (hEDS), hypermobility spectrum disorders (HSD) and fibromyalgia. The goal of this study was to determine whether symptoms and comorbidities overlap in patients diagnosed with hEDS\/HSD and\/or fibromyalgia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively examined self-reported data from an EDS Clinic intake questionnaire in patients diagnosed with hEDS\/HSD, fibromyalgia, or both vs. controls with an emphasis on joint issues.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 733 patients seen at the EDS Clinic, 56.5% (<jats:italic>n<\/jats:italic> = 414) were diagnosed with hEDS\/HSD and fibromyalgia (Fibro), 23.8% (<jats:italic>n<\/jats:italic> = 167) hEDS\/HSD, 13.3% (<jats:italic>n<\/jats:italic> = 98) fibromyalgia, or 7.4% (<jats:italic>n<\/jats:italic> = 54) none of these diagnoses. More patients were diagnosed with HSD (76.6%) than hEDS (23.4%). Patients were primarily White (95%) and female (90%) with a median age in their 30s (controls 36.7 [18.0, 70.0], fibromyalgia 39.7 [18.0, 75.0], hEDS\/HSD 35.0 [18.0, 71.0], hEDS\/HSD&amp;amp;Fibro 31.0 [18.0, 63.0]). There was high overlap in all 40 symptoms\/comorbidities that we examined in patients diagnosed with fibromyalgia only or hEDS\/HSD&amp;amp;Fibro, regardless of whether they had hEDS or HSD. Patients that only had hEDS\/HSD without fibromyalgia had far fewer symptoms\/comorbidities than patients with hEDS\/HSD&amp;amp;Fibro. The top self-reported issues in patients that only had fibromyalgia were joint pain, hand pain when writing or typing, brain fog, joint pain keeping from daily activities, allergy\/atopy and headache. Five issues that significantly and uniquely characterized patients diagnosed with hEDS\/HSD&amp;amp;Fibro were subluxations (dislocations in hEDS patients), joint issues like sprains, the need to stop sports due to injuries, poor wound healing, and migraine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The majority of patients seen at the EDS Clinic had a diagnosis of hEDS\/HSD plus fibromyalgia that was associated with more severe disease. Our findings indicate that fibromyalgia should be routinely assessed in patients with hEDS\/HSD and vis-a-versa to improve patient care.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2023.1096180","type":"journal-article","created":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T04:38:49Z","timestamp":1682397529000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":30,"title":["High overlap in patients diagnosed with hypermobile Ehlers-Danlos syndrome or hypermobile spectrum disorders with fibromyalgia and 40 self-reported symptoms and comorbidities"],"prefix":"10.3389","volume":"10","author":[{"given":"DeLisa","family":"Fairweather","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katelyn A.","family":"Bruno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley A.","family":"Darakjian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara K.","family":"Bruce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica M.","family":"Gehin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archana","family":"Kotha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angita","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongwei","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David O.","family":"Hodge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd D.","family":"Rozen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bala","family":"Munipalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando A.","family":"Rivera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro A.","family":"Malavet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dacre R. 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