{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:56:47Z","timestamp":1788267407999,"version":"build-2803163510"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T00:00:00Z","timestamp":1684972800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>Fusobacterium nucleatum<\/jats:italic> is a common oral symbiotic flora that can cause respiratory tract, oral nervous system, obstetric and skin infections. <jats:italic>Fusobacterium nucleatum<\/jats:italic> infections are mostly caused by aspiration. The clinical manifestations of pulmonary infections with <jats:italic>Fusobacterium nucleatum<\/jats:italic> can include simple pneumonia, lung abscesses, empyema, etc.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>We described the case of a 49-year-old man with a 1-year history of intermittent cough and sputum production who had worsened over the last 4 days with fever and right chest pain. After thoracentesis and catheter drainage were performed, <jats:italic>Fusobacterium nucleatum<\/jats:italic> was detected in the pleural effusion by using next-generation sequencing. Meanwhile, a diagnosis of squamous cell carcinoma of the right lung was made by fiberoptic bronchoscopy. The patient's condition improved significantly after percutaneous drainage and long-term intravenous antibiotic treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This is the first case reported of empyema due to <jats:italic>Fusobacterium nucleatum<\/jats:italic> infection in a patient with squamous cell carcinoma.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2023.1099040","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T04:54:07Z","timestamp":1684990447000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Empyema caused by Fusobacterium nucleatum with squamous cell carcinoma of the lung: a case report and literature review"],"prefix":"10.3389","volume":"10","author":[{"given":"Yue","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,5,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1016\/j.cmi.2018.11.030","article-title":"The bacterial aetiology of pleural empyema. 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