{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T08:05:52Z","timestamp":1792569952612,"version":"4.5.0"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T00:00:00Z","timestamp":1681689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>The association between sleep duration and cough, wheezing, and dyspnea was unclear. This research aimed to test this relationship.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Research data were obtained from people who participated in the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2012. We used weighted logistic regression analysis and fitted curves to explore the association between sleep and respiratory symptoms. In addition, we investigated the association between sleep duration, chronic obstructive pulmonary disease (COPD), and asthma. The stratified analysis is used to analyze inflection points and specific populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 14,742 subjects are weighted to reflect the 45,678,491 population across the United States. Weighted logistic regression and fitted curves show a U-shaped relationship between sleep duration and cough and dyspnea. This U-shaped relationship remained in people without COPD and asthma. The stratified analysis confirmed that sleep duration before 7.5 h was negatively associated with cough (HR 0.80, 95% CI 0.73\u20130.87) and dyspnea (HR 0.82, 95% CI 0.77\u20130.88). In contrast, it was positively associated with cough and (HR 1.30, 95% CI 1.14\u20131.48) dyspnea (HR 1.12, 95% CI 1.00\u20131.26) when sleep duration was &amp;gt;7.5 h. In addition, short sleep duration is associated with wheezing, asthma, and COPD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both long and short sleep duration are associated with cough and dyspnea. And short sleep duration is also an independent risk factor for wheezing, asthma, and COPD. This finding provides new insights into the management of respiratory symptoms and diseases.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2023.1108663","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T05:55:02Z","timestamp":1681710902000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":24,"title":["The association between sleep duration, respiratory symptoms, asthma, and COPD in adults"],"prefix":"10.3389","volume":"10","author":[{"given":"Zhishen","family":"Ruan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomeng","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minyan","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanjun","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianhai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,4,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.rmed.2007.10.012","article-title":"Respiratory symptoms, COPD severity, and health related quality of life in a general population sample.","volume":"102","author":"Voll-Aanerud","year":"2008","journal-title":"Respir Med."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0260416","article-title":"Respiratory symptoms and respiratory deaths: a multi-cohort study with 45 years observation time.","volume":"16","author":"Stavem","year":"2021","journal-title":"PLoS One."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-8-107","article-title":"Respiratory symptoms in adults are related to impaired quality of life, regardless of asthma and COPD: results from the European community respiratory health survey.","volume":"8","author":"Voll-Aanerud","year":"2010","journal-title":"Health Qual Life Outcomes."},{"key":"B4","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1111\/j.1365-2796.2006.01631.x","article-title":"Respiratory symptoms as predictors of all-cause mortality in an urban community: a 30-year follow-up.","volume":"259","author":"Frostad","year":"2006","journal-title":"J Intern Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"59","DOI":"10.3109\/15412555.2013.781578","article-title":"Lung function and respiratory symptoms in association with mortality: the HUNT study.","volume":"11","author":"Leivseth","year":"2014","journal-title":"COPD."},{"key":"B6","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.sleh.2015.10.004","article-title":"National sleep foundation\u2019s updated sleep duration recommendations: final report.","volume":"1","author":"Hirshkowitz","year":"2015","journal-title":"Sleep Health."},{"key":"B7","doi-asserted-by":"publisher","first-page":"829","DOI":"10.5665\/sleep.4684","article-title":"Trends in self-reported sleep duration among US adults from 1985 to 2012.","volume":"38","author":"Ford","year":"2015","journal-title":"Sleep."},{"key":"B8","doi-asserted-by":"publisher","first-page":"931","DOI":"10.5664\/jcsm.4950","article-title":"Joint consensus statement of the American academy of sleep medicine and sleep research society on the recommended amount of sleep for a healthy adult: methodology and discussion.","volume":"11","author":"Watson","year":"2015","journal-title":"J Clin Sleep Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.smrv.2007.03.010","article-title":"Who are the long sleepers? Towards an understanding of the mortality relationship.","volume":"11","author":"Grandner","year":"2007","journal-title":"Sleep Med Rev."},{"key":"B10","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1093\/aje\/kws308","article-title":"Sleeping at the limits: the changing prevalence of short and long sleep durations in 10 countries.","volume":"177","author":"Bin","year":"2013","journal-title":"Am J Epidemiol."},{"key":"B11","first-page":"1","article-title":"National health and nutrition examination survey: sample design, 2007-2010.","volume":"160","author":"Curtin","year":"2013","journal-title":"Vital Health Stat 2."},{"key":"B12","doi-asserted-by":"publisher","first-page":"2365","DOI":"10.3945\/jn.109.114025","article-title":"A new dietary inflammatory index predicts interval changes in serum high-sensitivity C-reactive protein.","volume":"139","author":"Cavicchia","year":"2009","journal-title":"J Nutr."},{"key":"B13","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1002\/oby.22370","article-title":"Trends in lipids, obesity, metabolic syndrome, and diabetes mellitus in the United States: an NHANES analysis (2003-2004 to 2013-2014).","volume":"27","author":"Palmer","year":"2019","journal-title":"Obesity."},{"key":"B14","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1161\/HYPERTENSIONAHA.117.09801","article-title":"Trends in the prevalence, awareness, treatment, and control of hypertension among young adults in the United States, 1999 to 2014.","volume":"70","author":"Zhang","year":"2017","journal-title":"Hypertension."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n604","article-title":"Associations of healthy lifestyle and socioeconomic status with mortality and incident cardiovascular disease: two prospective cohort studies.","volume":"373","author":"Zhang","year":"2021","journal-title":"BMJ."},{"key":"B16","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1164\/rccm.201905-0996OC","article-title":"Sex steroid hormones and asthma in a nationwide study of U.S. Adults.","volume":"201","author":"Han","year":"2020","journal-title":"Am J Respir Crit Care Med."},{"key":"B17","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1093\/ije\/27.6.962","article-title":"Respiratory symptoms and long-term risk of death from cardiovascular disease, cancer and other causes in Swedish men.","volume":"27","author":"Rosengren","year":"1998","journal-title":"Int J Epidemiol."},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2020.106060","article-title":"Respiratory symptoms and mortality in four general population cohorts over 45 years.","volume":"170","author":"Gulsvik","year":"2020","journal-title":"Respir Med."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1530","DOI":"10.1164\/ajrccm.153.5.8630597","article-title":"Association of chronic mucus hypersecretion with FEV1 decline and chronic obstructive pulmonary disease morbidity. Copenhagen city heart study group.","volume":"153","author":"Vestbo","year":"1996","journal-title":"Am J Respir Crit Care Med."},{"key":"B20","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1164\/rccm.200603-381OC","article-title":"Incidence of chronic obstructive pulmonary disease in a cohort of young adults according to the presence of chronic cough and phlegm.","volume":"175","author":"de Marco","year":"2007","journal-title":"Am J Respir Crit Care Med."},{"key":"B21","doi-asserted-by":"publisher","first-page":"2107","DOI":"10.1016\/j.rmed.2006.03.028","article-title":"Predictive value of respiratory symptoms and bronchial hyperresponsiveness to diagnose asthma in New Zealand.","volume":"100","author":"Sistek","year":"2006","journal-title":"Respir Med."},{"key":"B22","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1378\/chest.105.1.151","article-title":"The relation of sleep complaints to respiratory symptoms in a general population.","volume":"105","author":"Klink","year":"1994","journal-title":"Chest."},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-032511","article-title":"Are symptoms of insomnia related to respiratory symptoms? Cross-sectional results from 10 European countries and Australia.","volume":"10","author":"Bjornsdottir","year":"2020","journal-title":"BMJ Open."},{"key":"B24","doi-asserted-by":"publisher","first-page":"00010","DOI":"10.1183\/23120541.00010-2019","article-title":"Snoring and nocturnal reflux: association with lung function decline and respiratory symptoms.","volume":"5","author":"Emilsson","year":"2019","journal-title":"ERJ Open Res."},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1136\/bmjresp-2017-000206","article-title":"Respiratory symptoms are more common among short sleepers independent of obesity.","volume":"4","author":"Bj\u00f6rnsd\u00f3ttir","year":"2017","journal-title":"BMJ Open Respir Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.metabol.2018.04.001","article-title":"Association of sleep disturbances with obesity, insulin resistance and the metabolic syndrome.","volume":"84","author":"Koren","year":"2018","journal-title":"Metabolism."},{"key":"B27","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.jad.2021.09.075","article-title":"Association between sleep duration and depression in US adults: a cross-sectional study.","volume":"296","author":"Dong","year":"2022","journal-title":"J Affect Disord."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.952075","article-title":"Association between sleep duration and chest pain in US adults: a cross-sectional study.","volume":"10","author":"Chen","year":"2022","journal-title":"Front Public Health."},{"key":"B29","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.smrv.2017.11.001","article-title":"Association between long sleep duration and increased risk of obesity and type 2 diabetes: a review of possible mechanisms.","volume":"40","author":"Tan","year":"2018","journal-title":"Sleep Med Rev."},{"key":"B30","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.biopsych.2015.05.014","article-title":"Sleep disturbance, sleep duration, and inflammation: a systematic review and meta-analysis of cohort studies and experimental sleep deprivation.","volume":"80","author":"Irwin","year":"2016","journal-title":"Biol Psychiatry."},{"key":"B31","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1007\/s11325-017-1520-7","article-title":"The effect of sleep duration on exhaled nitric oxide levels in U.S. Adults.","volume":"21","author":"Hyde","year":"2017","journal-title":"Sleep Breath."},{"key":"B32","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1164\/rccm.201905-1004LE","article-title":"Sleep duration, current asthma, and lung function in a nationwide study of U.S. Adults.","volume":"200","author":"Yang","year":"2019","journal-title":"Am J Respir Crit Care Med."},{"key":"B33","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.anai.2020.04.035","article-title":"Associations of sleep duration with patient-reported outcomes and health care use in US adults with asthma.","volume":"125","author":"Luyster","year":"2020","journal-title":"Ann Allergy Asthma Immunol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.psychres.2017.07.036","article-title":"Sleep duration and its association with demographics, lifestyle factors, poor mental health and chronic diseases in older Chinese adults.","volume":"257","author":"Wang","year":"2017","journal-title":"Psychiatry Res."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1159\/000516381","article-title":"Sleep duration and its associations with mortality and quality of life in chronic obstructive pulmonary disease: results from the 2007-2015 KNAHNES.","volume":"100","author":"Kim","year":"2021","journal-title":"Respir Int Rev Thorac Dis."},{"key":"B36","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1378\/chest.91.4.540","article-title":"Prevalence of reported sleep disturbances in a general adult population and their relationship to obstructive airways diseases.","volume":"91","author":"Klink","year":"1987","journal-title":"Chest."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2023.1108663\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T05:55:04Z","timestamp":1681710904000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2023.1108663\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,17]]},"references-count":36,"alternative-id":["10.3389\/fmed.2023.1108663"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2023.1108663","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,17]]},"article-number":"1108663"}}