{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:00:29Z","timestamp":1753891229631,"version":"3.41.2"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T00:00:00Z","timestamp":1676246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Sympathetic ophthalmia (SO) is a rare but sight-threatening uveitis, and most observations have been made after typical manifestations occur. This report focuses on the choroidal changes detected by multimodal imaging at the presymptomatic stage of SO, which is implicated in the early recognition of SO.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 21-year-old woman suffered from decreased vision in the right eye and was diagnosed with retinal capillary hemangioblastomas associated with Von Hippel\u2013Lindau syndrome. The patient underwent two 23-G pars plana vitrectomies (PPVs), soon after which typical signs of SO manifested. SO resolved quickly after the oral administration of prednisone and remained stable during the follow-up of more than 1\u2009year. The retrospective analysis revealed preexisting bilaterally increased choroidal thickness, dots of flow void on the choroid, and choriocapillaris en-face slabs in optical coherence tomography angiography (OCTA) after the first PPV, which were all reversed by corticosteroid treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The case report highlights the involvement of the choroid and choriocapillaris at the presymptomatic stage of SO after the first inciting event. Abnormally thickened choroid and flow void dots suggested that SO had started and an ensuing surgery would run the risk of exacerbating SO. OCTA scanning of both eyes should be ordered routinely for patients with a history of trauma or intraocular surgeries, especially before the next surgical intervention. The report also suggests that non-human leukocyte antigen gene variation may also regulate the progression of SO, which requires further laboratory investigations.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2023.1118913","type":"journal-article","created":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T05:17:49Z","timestamp":1676265469000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case report: Sympathetic ophthalmia after vitrectomies in a patient with Von Hippel\u2013Lindau syndrome"],"prefix":"10.3389","volume":"10","author":[{"given":"Xiaonan","family":"Zhuang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengjuan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongcui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyi","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gezhi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,2,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.ophtha.2021.09.011","article-title":"Incidence of sympathetic ophthalmia after inciting events: a National Database Study in Japan","volume":"129","author":"Hashimoto","year":"2022","journal-title":"Ophthalmology"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s00417-005-0009-4","article-title":"Sympathetic ophthalmia in Singapore: new trends in an old disease","volume":"244","author":"Su","year":"2006","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1136\/bjo.84.5.448","article-title":"Sympathetic ophthalmia risk following vitrectomy: should we counsel patients?","volume":"84","author":"Kilmartin","year":"2000","journal-title":"Br J Ophthalmol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.oret.2022.01.012","article-title":"The risk of sympathetic ophthalmia after vitreoretinal surgery","volume":"6","author":"Anikina","year":"2022","journal-title":"Ophthalmol Retina"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1097\/ICU.0000000000000803","article-title":"Recent advances in diagnosis and management of sympathetic ophthalmia","volume":"32","author":"Fromal","year":"2021","journal-title":"Curr Opin Ophthalmol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/s12348-012-0065-y","article-title":"Sympathetic ophthalmia in HIV infection. 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