{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:27:53Z","timestamp":1791822473406,"version":"4.3.4"},"reference-count":53,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T00:00:00Z","timestamp":1680134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007322","name":"Binzhou Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Adenomyosis is a diffuse or localized organic disease caused by benign invasion of endometrial glands and stroma into the myometrium. It is a common disease that seriously affects reproductive health of women in childbearing age. Due to the unknown etiology and pathophysiological mechanism, and the lack of unified diagnostic criteria and effective treatment methods, total or subtotal hysterectomy has become a radical treatment for adenomyosis, which will lead to the complete loss of fertility. With the continuous exploration of the treatment to adenomyotic patients who have infertility or fertility intentions, new drugs, surgical methods and treating concepts appears. Adopt individualized conservative therapeutic strategies for patients with different conditions, preserve the uterus as much as possible and protect the patient\u2019s fertility, which will play an important role on the follow-up assisted reproductive treatment and long-term management of adenomyosis.<\/jats:p>","DOI":"10.3389\/fmed.2023.1133042","type":"journal-article","created":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T12:57:46Z","timestamp":1680181066000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Individualized conservative therapeutic strategies for adenomyosis with the aim of preserving fertility"],"prefix":"10.3389","volume":"10","author":[{"given":"Lei","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanni","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaixue","family":"Lao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxi","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanlin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,3,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1007\/s10815-022-02476-2","article-title":"Adenomyosis and infertility","volume":"39","author":"Moawad","year":"2022","journal-title":"J Assist Reprod Genet"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"4057","DOI":"10.3390\/jcm11144057","article-title":"Pathogenesis of human Adenomyosis: current understanding and its association with infertility","volume":"11","author":"Khan","year":"2022","journal-title":"J Clin Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1055\/s-0040-1718920","article-title":"Epidemiology of Adenomyosis","volume":"38","author":"Upson","year":"2020","journal-title":"Semin Reprod Med"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/s00404-021-06243-z","article-title":"Endometriosis treatment Italian, impact of endometriosis on obstetric outcome after natural conception: a multicenter Italian study","volume":"305","author":"Berlanda","year":"2022","journal-title":"Arch Gynecol Obstet"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1055\/s-0040-1716687","article-title":"Adenomyosis: mechanisms and pathogenesis","volume":"38","author":"Zhai","year":"2020","journal-title":"Semin Reprod Med"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.fertnstert.2017.12.030","article-title":"Pathogenesis of uterine adenomyosis: invagination or metaplasia?","volume":"109","author":"Garcia-Solares","year":"2018","journal-title":"Fertil Steril"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"2719","DOI":"10.1007\/s43032-021-00684-2","article-title":"The role of abnormal uterine junction zone in the occurrence and development of Adenomyosis","volume":"29","author":"Xie","year":"2022","journal-title":"Reprod Sci"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"485","DOI":"10.3390\/jcm9020485","article-title":"The pathogenesis of Adenomyosis Vis-a-Vis endometriosis","volume":"9","author":"Guo","year":"2020","journal-title":"J Clin Med"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1177\/1933719117691141","article-title":"Molecular characteristics of the endometrium in uterine Adenomyosis and its biochemical microenvironment","volume":"24","author":"Yen","year":"2017","journal-title":"Reprod Sci"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.ejogrb.2020.08.019","article-title":"Relationship between adenomyosis and endometriosis; different phenotypes of a single disease?","volume":"253","author":"Maruyama","year":"2020","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.ejogrb.2022.05.001","article-title":"'Guess who'? 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