{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:15:28Z","timestamp":1792718128592,"version":"4.5.0"},"reference-count":48,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T00:00:00Z","timestamp":1682380800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Inflammation is known to contribute to the development of age-related macular degeneration (AMD). Several inflammatory indices derived from routine complete blood counts have been proposed as biomarkers in multiple disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, clinical and laboratory data were retrospectively collected from medical records to assess the aggregate index of systemic inflammation (AISI) and the systemic inflammatory response index (SIRI) as potential biomarkers of systemic inflammation in patients with early diagnosis of dry AMD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study included 90 patients with dry AMD and 270 age\/sex-matched patients with cataracts as a control group. There were no significant differences in the AISI and SIRI results between the cases and controls (\n                      <jats:italic>p<\/jats:italic>\n                      =\u20090.16 and 0.19, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This suggests that AISI and SIRI may be inadequate metrics for AMD or lack sensitivity in detecting inflammatory changes. Exploring other routine blood markers may help to identify and prevent the early stages of AMD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2023.1143045","type":"journal-article","created":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T00:53:37Z","timestamp":1682384017000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":25,"title":["Assessment of aggregate index of systemic inflammation and systemic inflammatory response index in dry age-related macular degeneration: a retrospective study"],"prefix":"10.3389","volume":"10","author":[{"given":"Naif S.","family":"Sannan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,4,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1016\/S0140-6736(18)31550-2","article-title":"Age-related macular degeneration","volume":"392","author":"Mitchell","year":"2018","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e106","DOI":"10.1016\/S2214-109X(13)70145-1","article-title":"Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis","volume":"2","author":"Wong","year":"2014","journal-title":"Lancet Glob Health"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/978-3-030-27378-1_5","article-title":"Systemic inflammatory disease and AMD comorbidity","volume":"1185","author":"Schnabolk","year":"2019","journal-title":"Adv Exp Med Biol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"192","DOI":"10.3109\/08820538.2011.570849","article-title":"Inflammation and age-related macular degeneration (AMD)","volume":"26","author":"Telander","year":"2011","journal-title":"Semin Ophthalmol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.survophthal.2005.12.001","article-title":"The role of inflammation in the pathogenesis of age-related macular degeneration","volume":"51","author":"Donoso","year":"2006","journal-title":"Surv Ophthalmol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1001\/jama.291.6.704","article-title":"Association between C-reactive protein and age-related macular degeneration","volume":"291","author":"Seddon","year":"2004","journal-title":"J Am Med Assoc"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1111\/aos.14402","article-title":"Systemic levels of interleukin-6 in patients with age-related macular degeneration: a systematic review and meta-analysis","volume":"98","author":"Nahavandipour","year":"2020","journal-title":"Acta Ophthalmol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s12944-018-0954-7","article-title":"Serum lipids in adults with late age-related macular degeneration: a case-control study","volume":"18","author":"Semba","year":"2019","journal-title":"Lipids Health Dis"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/s12944-016-0262-z","article-title":"Interactive effects of C-reactive protein levels on the association between APOE variants and triglyceride levels in a Taiwanese population","volume":"15","author":"Wu","year":"2016","journal-title":"Lipids Health Dis"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1038\/ng.3448","article-title":"A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants","volume":"48","author":"Fritsche","year":"2016","journal-title":"Nat Genet"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1038\/eye.2017.245","article-title":"Genetics and genetic testing for age-related macular degeneration review-article","volume":"32","author":"Warwick","year":"2018","journal-title":"Eye"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1093\/aje\/kwm096","article-title":"Association between circulating white blood cell count and long-term incidence of age-related macular degeneration: the Blue Mountains eye study","volume":"166","author":"Shankar","year":"2007","journal-title":"Am J Epidemiol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"754","DOI":"10.18240\/ijo.2017.05.16","article-title":"Correlation of neutrophil\/lymphocyte and platelet\/lymphocyte ratio with visual acuity and macular thickness in age-related macular degeneration","volume":"10","author":"Sengul","year":"2017","journal-title":"Int J Ophthalmol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1007\/s11605-012-2121-1","article-title":"The prognostic value of the neutrophil-lymphocyte ratio (NLR) in acute pancreatitis: identification of an optimal NLR","volume":"17","author":"Suppiah","year":"2013","journal-title":"J Gastrointest Surg"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.clinre.2012.06.004","article-title":"Assessment of neutrophil-lymphocyte ratio in ulcerative colitis: a promising marker in predicting disease severity","volume":"36","author":"Torun","year":"2012","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"S127","DOI":"10.1016\/j.dsx.2016.12.021","article-title":"Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio as useful predictive markers of prediabetes and diabetes mellitus","volume":"11","author":"Mertoglu","year":"2017","journal-title":"Diabetes Metab Syndr"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"287","DOI":"10.3109\/09273948.2014.921715","article-title":"Assessment of neutrophil\/lymphocyte ratio in patients with age-related macular degeneration","volume":"23","author":"Ilhan","year":"2015","journal-title":"Ocul Immunol Inflamm"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"5701949","DOI":"10.1155\/2020\/5701949","article-title":"Low systemic inflammation response index predicts good prognosis in locally advanced pancreatic carcinoma patients treated with concurrent chemoradiotherapy","volume":"2020","author":"Topkan","year":"2020","journal-title":"Gastroenterol Res Pract"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.4143\/crt.2020.303","article-title":"High systemic inflammation response index (SIRI) indicates poor outcome in gallbladder cancer patients with surgical resection: a single institution experience in China","volume":"52","author":"Sun","year":"2020","journal-title":"Cancer Res Treat"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"2455","DOI":"10.1007\/s00432-017-2506-3","article-title":"Systemic inflammation response index (SIRI), cancer stem cells and survival of localised gastric adenocarcinoma after curative resection","volume":"143","author":"Li","year":"2017","journal-title":"J Cancer Res Clin Oncol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.2147\/CMAR.S235519","article-title":"Pretreatment systemic inflammation response index in patients with breast cancer treated with neoadjuvant chemotherapy as a useful prognostic indicator","volume":"12","author":"Chen","year":"2020","journal-title":"Cancer Manag Res"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"766","DOI":"10.3389\/fonc.2020.00766","article-title":"A novel prognostic marker systemic inflammation response index (SIRI) for operable cervical cancer patients","volume":"10","author":"Chao","year":"2020","journal-title":"Front Oncol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"685","DOI":"10.3855\/jidc.12879","article-title":"Laboratory test alterations in patients with COVID-19 and non COVID-19 interstitial pneumonia: a preliminary report","volume":"14","author":"Paliogiannis","year":"2020","journal-title":"J Infect Dev Ctries"},{"key":"ref24","article-title":"Blood cell count indexes of systemic inflammation as predictive biomarkers of immunotherapy outcomes in advanced non-small-cell lung cancer","author":"Paliogiannis","year":"2018"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1089\/ars.2012.5149","article-title":"Reactive oxygen species in inflammation and tissue injury","volume":"20","author":"Mittal","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/nri1785","article-title":"Neutrophils and immunity: challenges and opportunities","volume":"6","author":"Nathan","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1080\/09273948.2018.1485960","article-title":"Complete blood cell count-derived inflammation biomarkers in men with age-related macular degeneration","volume":"27","author":"Pinna","year":"2019","journal-title":"Ocul Immunol Inflamm"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/09273948.2022.2092752","article-title":"Neutrophil-lymphocyte ratios in dry age-related macular degeneration","author":"Naif","year":"","journal-title":"Ocul Immunol Inflamm"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1007\/s00262-018-2182-4","article-title":"Blood cell count indexes as predictors of outcomes in advanced non-small-cell lung cancer patients treated with Nivolumab","volume":"67","author":"Putzu","year":"2018","journal-title":"Cancer Immunol Immunother"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1111\/ans.14557","article-title":"Inflammatory cell indexes as preoperative predictors of hospital stay in open elective thoracic surgery","volume":"88","author":"Paliogiannis","year":"2018","journal-title":"ANZ J Surg"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1007\/s44197-021-00021-5","article-title":"Combined blood indexes of systemic inflammation as a Mirror to admission to intensive care unit in COVID-19 patients: a multicentric study","volume":"12","author":"Hamad","year":"2022","journal-title":"J Epidemiol Glob Health"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1007\/s00408-020-00386-7","article-title":"Blood cell count derived inflammation indexes in patients with idiopathic pulmonary fibrosis","volume":"198","author":"Zinellu","year":"2020","journal-title":"Lung"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"2158","DOI":"10.1002\/cncr.30057","article-title":"A novel systemic inflammation response index (SIRI) for predicting the survival of patients with pancreatic cancer after chemotherapy","volume":"122","author":"Qi","year":"2016","journal-title":"Cancer"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"3263","DOI":"10.1002\/hed.26375","article-title":"Prognostic value of preoperative systemic inflammation response index in patients with oral squamous cell carcinoma: propensity score-based analysis","volume":"42","author":"Lin","year":"2020","journal-title":"Head Neck"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1016\/j.ophtha.2009.04.017","article-title":"Nine-year incidence and risk factors for age-related macular degeneration in a defined Japanese population. The Hisayama study","volume":"116","author":"Yasuda","year":"2009","journal-title":"Ophthalmology"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1983","DOI":"10.1167\/iovs.06-0223","article-title":"Circulating inflammatory markers and hemostatic factors in age-related maculopathy: a population-based case-control study","volume":"48","author":"Wu","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"129","DOI":"10.3945\/ajcn.112.057091","article-title":"Homocysteine, folate, vitamin B-12, and 10-y incidence of age-related macular degeneration","volume":"98","author":"Gopinath","year":"2013","journal-title":"Am J Clin Nutr"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1111\/aos.14072,566","article-title":"Neutrophil-to-lymphocyte ratio in age-related macular degeneration: a systematic review and meta-analysis","volume":"97","author":"Niazi","year":"2019","journal-title":"Acta Ophthalmol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"251584142110105","DOI":"10.1177\/25158414211010550","article-title":"Is there a relationship between hematological inflammatory parameters and age-related macular degeneration?","volume":"13","author":"Karahan","year":"2021","journal-title":"Ther Adv Ophthalmol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/s41423-021-00832-3","article-title":"Neutrophils in chronic inflammatory diseases","volume":"19","author":"Herrero-Cervera","year":"2022","journal-title":"Cell Mol Immunol"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.1007\/s00018-016-2147-8","article-title":"Inflammation and its role in age-related macular degeneration","volume":"2016","author":"Kauppinen","year":"1765","journal-title":"Cell Mol Life Sci"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1111\/pin.12294","article-title":"Lymphocyte \u201choming\u201d and chronic inflammation","volume":"65","author":"Sakai","year":"2015","journal-title":"Pathol Int"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1038\/nri3070","article-title":"Monocyte recruitment during infection and inflammation","volume":"11","author":"Shi","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1177\/0003319715583186","article-title":"Association of Platelet to lymphocyte ratio with inflammation and severity of coronary atherosclerosis in patients with stable coronary artery disease","volume":"67","author":"Akboga","year":"2016","journal-title":"Angiology"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"899","DOI":"10.3233\/CBM-150534","article-title":"Application of platelet\/lymphocyte and neutrophil\/lymphocyte ratios in early diagnosis and prognostic prediction in patients with resectable gastric cancer","volume":"15","author":"Lian","year":"2015","journal-title":"Cancer Biomark"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/S0014-4835(81)80065-6","article-title":"The role of inflammation in radiation cataractogenesis","volume":"33","author":"Worgul","year":"1981","journal-title":"Exp Eye Res"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1667\/RR1688.1","article-title":"Radiation cataractogenesis: a review of recent studies","volume":"172","author":"Ainsbury","year":"2009","journal-title":"Radiat Res"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1097\/00055735-200102000-00002","article-title":"Control of intra-ocular inflammation associated with cataract surgery","volume":"12","author":"El-Harazi","year":"2001","journal-title":"Curr Opin Ophthalmol"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2023.1143045\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T00:53:51Z","timestamp":1682384031000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2023.1143045\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,25]]},"references-count":48,"alternative-id":["10.3389\/fmed.2023.1143045"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2023.1143045","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,25]]},"article-number":"1143045"}}