{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T09:30:09Z","timestamp":1783416609340,"version":"3.54.6"},"reference-count":14,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T00:00:00Z","timestamp":1676505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The cutaneous microangiopathy plays a key role in the development of the skin clinical lesions of venous insufficiency. Capillaroscopy allows a non-invasive observation of the superficial skin capillaries of the lower leg, which have previously been shown to be altered in patients with advanced venous disease. As it is now available in a friendly, easy to handle way through modern video devices, we report our findings in a short series of patients with C3\u2013C5 chronic venous disorders using this technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 21 patients with venous insufficiency (C3\u2013C5 on at least one leg) underwent a capillaroscopic examination of both legs and pictures recorded from the sites of the most severe venous skin lesions. This was performed with a CapXview handheld video-capillaroscope (\u00d7100 magnification), allowing easy manual measurement of maximum capillary bulk diameter and capillary density.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Dramatic changes in capillary density, size, and shape were easily observed at the site of the venous skin lesions. A significant negative linear relationship was found between capillary density and the \u201cC\u201d classes (<jats:italic>r<\/jats:italic> = \u22120.45; <jats:italic>P<\/jats:italic> &amp;lt; 0.001). A significant negative correlation was also found between capillary density and bulk diameter (<jats:italic>r<\/jats:italic> = \u22120.52; <jats:italic>P<\/jats:italic> &amp;lt; 0.001). The area under the ROC curve for the mathematical prediction of venous skin changes by capillary density was 0.842, which shows the strength of the link between the microvascular and the clinical status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Video-capillaroscopy allows a direct observation of the cutaneous venous microangiopathy and provides the possibility to measure capillary density which allows its quantification. This simple to use technique shows the potential for a more precise follow-up and treatment evaluation of the cutaneous consequences of venous disease, which remains to be further investigated.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2023.1144102","type":"journal-article","created":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T11:32:58Z","timestamp":1676547178000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Video-capillaroscopy, a promising tool for the clinical evaluation of patients with chronic venous insufficiency"],"prefix":"10.3389","volume":"10","author":[{"given":"Patrick H.","family":"Carpentier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corine","family":"Trolliet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Cornu-Th\u00e9nard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9my","family":"Chamberod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Laur\u00e8s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janick","family":"Noilhetas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Chauvin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,2,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1258\/phleb.2007.007061","article-title":"Epidemiology of chronic venous disease.","volume":"23","author":"Robertson","year":"2008","journal-title":"Phlebology."},{"key":"B2","doi-asserted-by":"publisher","first-page":"S5","DOI":"10.1007\/s12325-019-0881-7","article-title":"The seriousness of chronic venous disease: a review of real-world evidence.","volume":"36","author":"Davies","year":"2019","journal-title":"Adv Ther."},{"key":"B3","first-page":"236","article-title":"Venous hemodynamic changes in lower limb venous disease: the UIP consensus according to scientific evidence.","volume":"35","author":"Lee","year":"2016","journal-title":"Int Angiol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1038\/jid.1954.25","article-title":"Capillary microscopy in the diagnosis of dermatologic diseases.","volume":"22","author":"Gilje","year":"1954","journal-title":"J Invest Dermatol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1161\/01.CIR.70.5.806","article-title":"Transcutaneous oxygen tension 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ulcer risk index: a new prognostic tool for digital skin ulcer development in systemic sclerosis patients.","volume":"61","author":"Sebastiani","year":"2009","journal-title":"Arthritis Rheum."},{"key":"B13","first-page":"63","article-title":"Correlation between capillaroscopic classifications and severity in systemic sclerosis: results from SCLEROCAP study at inclusion.","volume":"37","author":"Boulon","year":"2019","journal-title":"Clin Exp Rheumatol."},{"key":"B14","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1113\/jphysiol.1919.sp001839","article-title":"The number and distribution of capillaries in muscles with calculations of the oxygen pressure head necessary for supplying the tissue.","volume":"52","author":"Krogh","year":"1919","journal-title":"J Physiol."}],"container-title":["Frontiers in 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