{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:19:46Z","timestamp":1791886786956,"version":"4.3.4"},"reference-count":83,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T00:00:00Z","timestamp":1681948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Cryptogenic organizing pneumonia (COP) is a form of idiopathic interstitial pneumonia that results from the pulmonary reaction to various unidentified injuries. Secondary organizing pneumonia is diagnosed when the triggering factor has been identified; it is mainly caused by infections, toxic substance exposure, drugs, connective tissue diseases, malignancies, autoimmune diseases, bone marrow, or organ transplantation, and radiotherapy. There has been an increase in the number of reports of drug-induced organizing pneumonia (OP). New biological therapies, interferon, monoclonal antibodies, anti-interleukin antibodies, and PD1\/PDL-1 inhibitors may induce this specific pulmonary reaction. The classical form of COP is usually subacute and does not manifest as severe disease. Patients maintain sufficient respiratory function, and treatment with steroids is usually effective. Several specific forms of OP (e.g., the cicatricial variant or acute fibrinous type) have distinct clinical and histological features, require higher doses of immunosuppressive drugs, and have a worse prognosis. In the era of administering steroid-sparing therapies for the treatment of interstitial lung diseases, connective tissue dases, and other conditions, it is important to emphasize this type of therapy for patients with COP.<\/jats:p>","DOI":"10.3389\/fmed.2023.1146782","type":"journal-article","created":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T18:24:26Z","timestamp":1682015066000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":42,"title":["Update on cryptogenic organizing pneumonia"],"prefix":"10.3389","volume":"10","author":[{"given":"Elzbieta","family":"Radzikowska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyna","family":"Fijolek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,4,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1164\/rccm.201308-1483ST","article-title":"An official American Thoracic Society\/European Respiratory Society statement: update of the international multidisciplinary classification of the idiopathic interstitial pneumonias","volume":"188","author":"Travis","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2S","DOI":"10.1378\/chest.102.1.2S","article-title":"Bronchiolitis obliterans organizing pneumonia: definition and clinical features","volume":"102","author":"Epler","year":"1992","journal-title":"Chest"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1183\/09031936.06.00013505","article-title":"Cryptogenic organising pneumonia","volume":"28","author":"Cordier","year":"2006","journal-title":"Eur Respir J"},{"key":"ref4","first-page":"382","article-title":"Cryptogenic organizing pneumonitis","volume":"52","author":"Davison","year":"1983","journal-title":"Q J Med"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1056\/NEJM198501173120304","article-title":"Bronchiolitis obliterans organizing pneumonia","volume":"312","author":"Epler","year":"1985","journal-title":"N Engl J Med"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1056\/NEJMra2116777","article-title":"Cryptogenic organizing pneumonia","volume":"386","author":"King","year":"2022","journal-title":"NEJM"},{"key":"ref7","first-page":"427","article-title":"Progressive airway obliteration in adults and its association with rheumatoid disease","volume":"46","author":"Geddes","year":"1977","journal-title":"Q J Med"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1378\/chest.96.5.999","article-title":"Idiopathic bronchiolitis obliterans organizing pneumonia. Definition of characteristic clinical profiles in a series of 16 patients","volume":"96","author":"Cordier","year":"1989","journal-title":"Chest"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1183\/09059180.00002410","article-title":"Organising pneumonia can be the inaugural manifestation in connective tissue diseases, including Sjogren\u2019s syndrome","volume":"19","author":"Henriet","year":"2010","journal-title":"Eur Respir Rev"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"686","DOI":"10.4187\/respcare.07150","article-title":"Post-breast cancer radiotherapy bronchiolitis Obliterans organizing pneumonia","volume":"65","author":"Epler","year":"2020","journal-title":"Respir Care"},{"key":"ref11","first-page":"394","article-title":"Organising pneumonia and lung cancer - case report and review of the literature","volume":"75","author":"Radzikowska","year":"2007","journal-title":"Pneumonol Alergol Pol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1183\/09031936.03.00035502","article-title":"Organising pneumonia caused by trastuzumab (Herceptin) therapy for breast cancer","volume":"21","author":"Radzikowska","year":"2003","journal-title":"Eur Respir J"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"e5788","DOI":"10.1097\/MD.0000000000005788","article-title":"Micronodular pattern of organizing pneumonia: case report and systematic literature review","volume":"96","author":"Lebargy","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1093\/rheumatology\/keq410","article-title":"Comparison between cryptogenic organizing pneumonia and connective tissue disease-related organizing pneumonia","volume":"50","author":"Yoo","year":"2011","journal-title":"Rheumatology (Oxford)"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1164\/ajrccm.158.6.9711036","article-title":"Bronchiolitis obliterans organizing pneumonia syndrome primed by radiation therapy to the breast. The Groupe dEtudes ET de Recherche sur les maladies Orphelines Pulmonaries (GERM\"O\"P)","volume":"158","author":"Crestani","year":"1998","journal-title":"Am J Respir Dis"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"2311","DOI":"10.2169\/internalmedicine.8271-16","article-title":"Nivolumab-induced acute Fibrinous and organizing pneumonia (AFOP)","volume":"56","author":"Ishiwata","year":"2017","journal-title":"Intern Med"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.medcli.2020.04.058","article-title":"Cryptogenic organizing pneumonia by alectinib","volume":"157","author":"L\u00f3pez Pardo","year":"2021","journal-title":"Med Clin (Barc)"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"2248","DOI":"10.3390\/ijerph17072248","article-title":"Beghrakis P.a systematic literature review of E-cigarette-related illness and injury: not just for the Respirologist","volume":"17","author":"Tzortzi","year":"2020","journal-title":"Int J Environ Res Public Health"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.5858\/2002-126-1064-AFAOP","article-title":"Acute fibrinous and organizing pneumonia: a histological pattern of lung injury and possible variant of diffuse alveolar damage","volume":"126","author":"Beasley","year":"2002","journal-title":"Arch Pathol Lab Med"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s12890-022-01852-z","article-title":"Clinical features and long-term prognosis of acute fibrinous and organizing pneumonia histologically confirmed by surgical lung biopsy","volume":"22","author":"Kim","year":"2022","journal-title":"BMC Pulm Med"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1164\/ajrccm.149.6.8004328","article-title":"Rapidly progressive bronchiolitis obliterans with organizing pneumonia","volume":"149","author":"Cohen","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1136\/jclinpath-2012-201342","article-title":"Fibrosing organising pneumonia","volume":"66","author":"Beardsley","year":"2013","journal-title":"J Clin Pathol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"e0249300","DOI":"10.1371\/journal.pone.0249300","article-title":"Clinical features of acute fibrinous and organizing pneumonia: an early histologic pattern of various acute inflammatory lung diseases","volume":"16","author":"Onishi","year":"2021","journal-title":"PLoS One"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/s13000-021-01155-7","article-title":"Acute fibrinous and organizing pneumonia: two case reports and literature review","volume":"16","author":"Chen","year":"2021","journal-title":"Diagn Pathol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.humpath.2017.03.018","article-title":"Cicatricial variant of cryptogenic organizing pneumonia","volume":"64","author":"Yousem","year":"2017","journal-title":"Human"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1136\/thx.2006.059469","article-title":"Epidemiology of organising pneumonia in Iceland","volume":"61","author":"Gudmundsson","year":"2006","journal-title":"Thorax"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1016\/j.rmed.2009.03.001","article-title":"Hellenic interstitial lung diseases group. Epidemiology of interstitial lung diseases in Greece","volume":"103","author":"Karakatsani","year":"2009","journal-title":"Respir Med"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1164\/ajrccm.162.2.9909015","article-title":"Characteristics of relapses in a series of 48 patients. The Groupe d\u2019Etudes et de Recherche sur les Maladles \u2018Orphelines\u2019 Pulmonaires (GERM\u2018O\u2019P)","volume":"162","author":"Lazor","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"e0184739","DOI":"10.1371\/journal.pone.0184739","article-title":"Cryptogenic organizing pneumonia \u2013 results of treatment with clarithromycin versus corticosteroids \u2013 observational study","volume":"12","author":"Radzikowska","year":"2017","journal-title":"PLoS One"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1378\/chest.102.3.715","article-title":"Bronchiolitis obliterans organizing pneumonia","volume":"102","author":"Izumi","year":"1992","journal-title":"Chest"},{"key":"ref31","first-page":"8S","article-title":"Cryptogenic organizing pneumonitis","volume":"102","author":"King","year":"1992","journal-title":"North Am Exp Chest"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1097\/00005792-199507000-00004","article-title":"Cryptogenic organizing pneumonia. A report of 25 cases and a review of the literature","volume":"74","author":"Alasaly","year":"1995","journal-title":"Medicine (Baltimore)"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1053\/rmed.2000.0805","article-title":"Bronchiolitis obliterans-organizing pneumonia: an Italian experience","volume":"94","author":"Cazzato","year":"2000","journal-title":"Respir Med"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1159\/000085366","article-title":"Bronchiolitis obliterans organizing pneumonia","volume":"72","author":"Oymak","year":"2005","journal-title":"Respiration"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"179","DOI":"10.3346\/jkms.2002.17.2.179","article-title":"Bronchiolitis obliterans organizing pneumonia: clinicopathologic review of a series of 45 Korean patients including rapidly progressive form","volume":"17","author":"Chang","year":"2002","journal-title":"J Korean Med Sci"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.5578\/tt.53938","article-title":"Retrospective evaluation of patients with organizing pneumonia: is cryptogenic organizing pneumonia different from secondary organizing pneumonia?","volume":"65","author":"Y\u0131lmaz","year":"2017","journal-title":"Tuberk Toraks"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"147997311985382","DOI":"10.1177\/1479973119853829","article-title":"A long-term retrospective study of patients with biopsy-proven cryptogenic organizing pneumonia","volume":"16","author":"Zhou","year":"2019","journal-title":"Chron Respir Dis"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1378\/chest.10-0883","article-title":"Cryptogenic and secondary organizing pneumonia","volume":"139","author":"Drakopanagiotakis","year":"2011","journal-title":"Chest"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.resinv.2016.09.001","article-title":"Factors associated with the relapse of cryptogenic and secondary organizing pneumonia","volume":"55","author":"Onishi","year":"2017","journal-title":"Respir Investig"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"763","DOI":"10.21037\/atm-20-4490","article-title":"Analysis of the clinical characteristics of 176 patients with pathologically confirmed cryptogenic organizing pneumonia","volume":"8","author":"Zhang","year":"2020","journal-title":"Ann Transl Med"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"38S","DOI":"10.1378\/chest.102.1.38S","article-title":"Pathologic aspects of bronchiolitis obliterans organizing pneumonia","volume":"102","author":"Colby","year":"1992","journal-title":"Chest"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/S0272-5231(21)00925-4","article-title":"Pathologic manifestations of bronchiolitis, constrictive bronchiolitis, cryptogenic organizing pneumonia, and diffuse panbronchiolitis","volume":"14","author":"Myers","year":"1993","journal-title":"Clin Chest Med"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1136\/jclinpath-2014-202626","article-title":"A comparison of the pathological, clinical and radiographical, features of cryptogenic organising pneumonia, acute fibrinous and organising pneumonia and granulomatous organising pneumonia","volume":"68","author":"Feinstein","year":"2015","journal-title":"J Clin Pathol"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1007\/PL00007654","article-title":"Apoptotic activity is increased in the newly formed fibromyxoid connective tissue in bronchiolitis obliterans organizing pneumonia","volume":"177","author":"Lappi-Blanco","year":"1999","journal-title":"Lung"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1016\/S0046-8177(99)90036-9","article-title":"Intraluminal fibromyxoid lesions in bronchiolitis obliterans organizing pneumonia are highly capillarized","volume":"30","author":"Lappi-Blanco","year":"1999","journal-title":"Hum Pathol"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1016\/j.imbio.2012.10.014","article-title":"Macrolides inhibit cytokine production by alveolar macrophages in bronchiolitis obliterans organizing pneumonia","volume":"218","author":"Cai","year":"2013","journal-title":"Immunobiology"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/5584_2016_223","article-title":"Cryptogenic organizing pneumonia: IL-1\u03b2, IL-6, IL-8, and TGF- \u03b21 serum concentrations and response to clarithromycin treatment","volume":"911","author":"Radzikowska","year":"2016","journal-title":"Adv Exp Med Biol"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"871","DOI":"10.17219\/acem\/61953","article-title":"Clarithromycin decreases IL-6 concentration in serum and BAL fluid in patients with cryptogenic organizing pneumonia","volume":"25","author":"Radzikowska","year":"2016","journal-title":"Clin Exp Med"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1007\/s00408-015-9775-x","article-title":"Increased Galectin-9 concentration and number of CD4+Foxp3high+cells in bronchoalveolar lavage fluid of patients with cryptogenic organizing pneumonia","volume":"193","author":"Katoh","year":"2015","journal-title":"Lung"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1016\/j.rmed.2015.09.015","article-title":"Organizing pneumonia\/non-specific interstitial pneumonia overlap is associated with unfavorable lung disease progression","volume":"109","author":"Todd","year":"2015","journal-title":"Respir Med"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1046\/j.1440-1843.1999.00187.x","article-title":"Idiopathic bronchiolitis obliterans with organizing pneumonia presenting with spontaneous hydropneumothorax and solitary pulmonary nodule","volume":"4","author":"Yang","year":"1999","journal-title":"Respirology"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.rmcr.2017.06.006","article-title":"Cryptogenic organising pneumonia presenting with spontaneous pneumothorax and the value of procalcitonin: a case report","volume":"22","author":"Kang","year":"2017","journal-title":"Respir Med Case Rep"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1164\/rccm.201202-0320ST","article-title":"An official American Thoracic Society clinical practice guideline: the clinical utility of bronchoalveolar lavage cellular analysis in interstitial lung disease","volume":"185","author":"Meyer","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1183\/09031936.93.05070791","article-title":"Bronchiolitis obliterans organizing pneumonia (BOOP): the cytological and immunocytological profile of bronchoalveolar lavage","volume":"5","author":"Costabel","year":"1992","journal-title":"Eur Respir J"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"2513","DOI":"10.1183\/09031936.96.09122513","article-title":"The diagnostic value of bronchoalveolar lavage and transbronchial lung biopsy in cryptogenic organizing pneumonia","volume":"9","author":"Poletti","year":"1996","journal-title":"Eur Respir J"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s12890-019-0780-3","article-title":"Diagnostic yield and risk\/benefit analysis of trans-bronchial lung cryobiopsy in diffuse parenchymal lung diseases: a large cohort of 699 patients","volume":"19","author":"Ravaglia","year":"2019","journal-title":"BMC Pulm Med"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"2244","DOI":"10.1007\/s00330-011-2191-6","article-title":"Organizing pneumonia: a kaleidoscope of concepts and morphologies","volume":"21","author":"Roberton","year":"2011","journal-title":"Eur Radiol"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.3978\/j.issn.2072-1439.2014.08.23","article-title":"Lesion with morphologic feature of organizing pneumonia (OP) in CT-guided lung biopsy samples for diagnosis of bronchiolitis obliterans organizing pneumonia (BOOP): a retrospective study of 134 cases in a single center","volume":"6","author":"Miao","year":"2014","journal-title":"J Thorac Dis"},{"key":"ref59","first-page":"705","article-title":"A comparison of bronchiolitis obliterans with organizing pneumonia, usual interstitial pneumonia, and small airways disease","volume":"135","author":"Guerry-Force","year":"1987","journal-title":"Am Rev Respir Dis"},{"key":"ref60","first-page":"64","article-title":"Spanish group on interstitial lung diseases, SEPAR. Report on the incidence of interstitial lung diseases in Spain","volume":"21","author":"Xaubet","year":"2004","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"ref61","first-page":"864","article-title":"Idiopathic bronchiolitis obliterans organizing pneumonia\/cryptogenic organizing pneumonia with unfavorable outcome: pathologic predictors","volume":"10","author":"Yousem","year":"1997","journal-title":"Mod Pathol"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1001\/archinte.1997.00440330057006","article-title":"Organizing pneumonia. Features and prognosis of cryptogenic, secondary, and focal variants","volume":"157","author":"Lohr","year":"1997","journal-title":"Arch Intern Med"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1159\/000103240","article-title":"Idiopathic organizing pneumonia: a relapsing disease. 19 years of experience in a hospital setting","volume":"74","author":"Barroso","year":"2007","journal-title":"Respiration"},{"key":"ref64","first-page":"689","article-title":"Clinical features in secondary and cryptogenic organising pneumonia","volume":"11","author":"Sveinsson","year":"2007","journal-title":"Int J Tuberc Lung Dis"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1378\/chest.108.1.271","article-title":"Idiopathic bronchiolitis obliterans with organizing pneumonia an acute and life-threatening syndrome","volume":"108","author":"Nizami","year":"1995","journal-title":"Chest"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s12890-018-0764-8","article-title":"Predictive factors for relapse of cryptogenic organizing pneumonia","volume":"19","author":"Saito","year":"2019","journal-title":"BMC Pulm Med"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"65","DOI":"10.2739\/kurumemedj.40.65","article-title":"Low-dose\/long-term erythromycin for treatment of bronchiolitis obliterans organizing pneumonia (BOOP)","volume":"40","author":"Ichikawa","year":"1993","journal-title":"Kurume Med J"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"493","DOI":"10.5603\/ARM.28186","article-title":"Organizing pneumonia-own experiences with clarithromycin treatment","volume":"72","author":"Radzikowska","year":"2004","journal-title":"Pneumonol Alergol Pol"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"3611","DOI":"10.1378\/chest.128.5.3611","article-title":"Macrolides: a treatment alternative for bronchiolitis obliterans organizing pneumonia?","volume":"128","author":"Stover","year":"2005","journal-title":"Chest"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"829","DOI":"10.3892\/etm.2015.2183","article-title":"Macrolide therapy in cryptogenic organizing pneumonia: a case report and literature review","volume":"9","author":"Ding","year":"2015","journal-title":"Exp Ther Med"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1513\/AnnalsATS.201308-261CR","article-title":"Macrolide use leads to clinical and radiological improvement in patients with cryptogenic organizing pneumonia","volume":"11","author":"Pathak","year":"2014","journal-title":"Ann Am Thorac Soc"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"475","DOI":"10.2169\/internalmedicine.50.4237","article-title":"Adjunctive effects of cyclosporine and macrolide in rapidly progressive cryptogenic organizing pneumonia with no prompt response to steroid","volume":"50","author":"Lee","year":"2011","journal-title":"Intern Med"},{"key":"ref73","first-page":"129","article-title":"Organizing pneumonia revisited: insights and uncertainties from a series of 67 patients","volume":"35","author":"Vieira","year":"2018","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"ref74","first-page":"165","article-title":"Seven patients with cryptogenic organizing pneumonia succesfully treated with clarithromycin","volume":"35","author":"Ciftci","year":"2018","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"ref75","first-page":"230","article-title":"A 12-week combination of clarithromycin and prednisone compared to a 24-week prednisone alone treatment in cryptogenic and radiation-induced organizing pneumonia","volume":"35","author":"Petitpierre","year":"2018","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.humpath.2013.09.010","article-title":"Clinicopathologic features associated with relapse in cryptogenic organizing pneumonia","volume":"45","author":"Nishino","year":"2014","journal-title":"Hum Pathol"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"e4073","DOI":"10.1097\/MD.0000000000004073","article-title":"Acute fibrinous and organizing pneumonia: a report of 13 cases in a tertiary university hospital","volume":"95","author":"Gomes","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"2701","DOI":"10.4103\/0366-6999.167293","article-title":"Clinical and radiological profile of acute fibrinous and organizing pneumonia: a retrospective study","volume":"128","author":"Dai","year":"2015","journal-title":"Chin Med J"},{"key":"ref79","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1186\/s12890-019-0861-3","article-title":"Acute fibrinous and organizing pneumonia: two case reports and literature review","volume":"19","author":"Lu","year":"2019","journal-title":"BMC Pulm Med"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"3958","DOI":"10.3892\/etm.2016.3865","article-title":"Acute fibrinous and organizing pneumonia: a case report and literature review","volume":"12","author":"Xu","year":"2016","journal-title":"Exp Ther Med"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"7283","DOI":"10.1007\/s00330-021-07868-z","article-title":"Diagnostic procedures and clinico-radiological findings of acute fibrinous and organizing pneumonia: a systematic review and pooled analysis","volume":"31","author":"Lee","year":"2021","journal-title":"Eur Radiol"},{"key":"ref82","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1111\/his.14427","article-title":"Cicatricial organising pneumonia associated with fibrosing interstitial pneumonia\u2009-\u2009a clinicopathological study","volume":"80","author":"Zaizen","year":"2022","journal-title":"Histopathology"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.humpath.2020.04.013","article-title":"Cicatricial organizing pneumonia: a clinicopathologic and radiologic study on a cohort diagnosed by surgical lung biopsy at a single institution","volume":"101","author":"Woge","year":"2020","journal-title":"Hum Pathol"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2023.1146782\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T18:24:48Z","timestamp":1682015088000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2023.1146782\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,20]]},"references-count":83,"alternative-id":["10.3389\/fmed.2023.1146782"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2023.1146782","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,20]]},"article-number":"1146782"}}