{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T18:43:01Z","timestamp":1793126581734,"version":"4.5.0"},"reference-count":70,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T00:00:00Z","timestamp":1690502400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Glaucoma, the leading cause of irreversible blindness, is a common disorder that contributes to gradual optic nerve degeneration. The beneficial impacts of uric acid (UA) have been reported in some neurodegenerative conditions such as Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis. But the results of current studies about the association between serum UA level and glaucoma are conflicting. The present meta-analysis was conducted to provide a better understanding of the association between serum UA level and glaucoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched the databases of PubMed, Scopus, Web of Science, and Google Scholar systematically until November 20, 2022 to identify case-control studies, comparing the serum UA concentrations of the patients with glaucoma and controls. The mean \u00b1 standard division difference was used to assess the difference in serum UA concentrations between the glaucoma patients and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six studies involving 1,221 glaucoma patients and 1,342 control group were included in the present meta-analysis. This meta-analysis using a random effect model indicated that the mean UA level in glaucoma patients was 0.13 (<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> = 91.92%, 95% CI = \u22120.42 to 0.68) higher than the controls; however, it was not statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings provide evidence that glaucoma patients have a higher serum UA level compared to the controls, but this difference is not statistically significant. Prospective studies are needed to determine the possible association between increased UA and glaucoma pathogenesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Systematic review registration<\/jats:title><jats:p><jats:ext-link>https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?ID=CRD42022364055<\/jats:ext-link>, identifier: CRD42022364055.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2023.1159316","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T11:22:18Z","timestamp":1690543338000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Uric acid and glaucoma: a systematic review and meta-analysis"],"prefix":"10.3389","volume":"10","author":[{"given":"Mohammad","family":"Mohammadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeleh","family":"Yarmohammadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Salehi-Abargouei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamidreza","family":"Ghasemirad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Shirvani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamed","family":"Ghoshouni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,7,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e144","DOI":"10.1016\/S2214-109X(20)30489-7","article-title":"Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the Right to Sight: an analysis for the Global Burden of Disease Study","volume":"9","author":"Steinmetz","year":"2021","journal-title":"Lancet Global Health."},{"key":"B2","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.jneuroim.2016.12.010","article-title":"Alteration of CD39+Foxp3+ CD4 T cell and cytokine levels in EAE\/MS following anti-CD52 treatment","volume":"303","author":"Pant","year":"2017","journal-title":"J Neuroimmunol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"16023","DOI":"10.1038\/sigtrans.2016.23","article-title":"Erratum: genetic and environmental factors strongly influence risk, severity and progression of age-related macular degeneration","volume":"1","author":"Wang","year":"2016","journal-title":"Signal Transduct Target Ther."},{"key":"B4","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis","volume":"121","author":"Tham YC Li","year":"2014","journal-title":"Ophthalmology."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1016\/j.ophtha.2012.11.043","article-title":"How does glaucoma look?","volume":"120","author":"Crabb","year":"2013","journal-title":"Ophthalmology."},{"key":"B6","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/S0002-9394(00)00538-9","article-title":"The relationship between control of intraocular pressure and visual field deterioration. 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