{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T15:41:45Z","timestamp":1773416505049,"version":"3.50.1"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T00:00:00Z","timestamp":1684108800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate the differences between 0.2 and 0.15% brimonidine tartrate eye drops for anti-mydriatic effects and the optical quality under different light conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective study involved 80 consecutive high myopia patients undergoing implantation of a V4c ICL. The patients were randomly instilled with brimonidine 0.2 and 0.15% 2\u2009weeks postoperatively. Visual quality, pupil center, pupil size, and refraction under different light conditions were measured before and 0.5\u2009h after brimonidine administration. A symptom questionnaire was also evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no statistical difference in the static and dynamic pupil diameters and velocity after LS between the two groups (<jats:italic>p<\/jats:italic>\u2009&amp;gt;\u20090.05). The 0.2% group had significant changes in pupil center before and after treatment, while there was no obvious movement of the 0.15% group under all illumination condition (<jats:italic>p<\/jats:italic>\u2009&amp;gt;\u20090.05). The OSI after treatment of the 0.15% group was lower than that of 0.2% group (<jats:italic>p<\/jats:italic>\u2009=\u20090.012). The PVA9% and PVA100% of the 0.15% group was higher than that of 0.2% group in the dark (<jats:italic>p<\/jats:italic>\u2009=\u20090.009, <jats:italic>p<\/jats:italic>\u2009=\u20090.012). The HOA RMS of the 0.15% group was lower than that of 0.2% group (<jats:italic>p<\/jats:italic>\u2009=\u20090.016). The QIRC score in the 0.15% group was significantly higher than that in the 0.2% group (<jats:italic>p<\/jats:italic>\u2009=\u20090.043).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>0.15 and 0.2% brimonidine tartrate eye drops had similar anti-mydriatic ability, while 0.15% group had better visual quality than 0.2% concentration, and hardly introduced pupil shift. 0.15% brimonidine tartrate eye drops may be more suitable for patients with nocturnal glare symptoms in the early postoperative period after ICL implantation.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2023.1160414","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T04:38:36Z","timestamp":1684125516000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of brimonidine tartrate 0.2 and 0.15% ophthalmic solution on the static and dynamic pupil characteristics"],"prefix":"10.3389","volume":"10","author":[{"given":"Jing","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhui","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wentao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinge","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiqun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,5,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2779","DOI":"10.4103\/ijo.IJO_2995_20","article-title":"Phakic 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