{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T06:17:23Z","timestamp":1783577843332,"version":"3.55.0"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013285","name":"Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013285","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to test the inter-examiner and intra-examiner reliability of macular vascular density (VD) measurement of retinal and choriocapillaris plexuses in healthy children using optical coherence tomography angiography (OCTA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Ninety-two school children were prospectively recruited. Macular OCTA images (6 \u00d7 6 mm<jats:sup>2<\/jats:sup>) were obtained thrice by two examiners using the RTVue-XR Avanti OCT system. The coefficient of variation (COV), intraclass correlation coefficient (ICC), and Bland\u2013Altman plots were used to evaluate the repeatability and reproducibility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety participants aged 6\u201315 years were enrolled; two participants were excluded because of low-quality images. In the retina, the reproducibility and repeatability of VD became poorer from superficial to deep retinal capillary plexus (superficial: COV\u2009=\u20094.61\u201311.11%; intermediate: COV\u2009=\u20097.73\u201314.15%; deep: COV\u2009=\u200914.60\u201332.28%). For both reproducibility and repeatability, the ICC ranged from moderate to high (superficial plexus: ICC\u2009=\u20090.570\u20130.976; intermediate plexus: ICC\u2009=\u20090.720\u20130.968; deep plexus: ICC\u2009=\u20090.628\u20130.954). In the choroid, the inter-examiner reproducibility and intra-examiner repeatability of the VD measurement of choriocapillaris were excellent in the macula, fovea, parafovea, and perifovea (COV\u2009=\u20091.00\u20136.10%; ICC\u2009=\u20090.856\u20130.950). The parameters of the foveal avascular zone (FAZ) also showed significant reproducibility and repeatability (COV\u2009=\u20090.01\u20130.21%; ICC\u2009=\u20090.743\u20130.994).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The VD measurements of the choriocapillaris and FAZ parameters using OCTA showed excellent inter-examiner and intra-examiner reliability in school children. The reproducibility and repeatability of the VD of three retinal capillary plexuses depended on the depth of the retinal capillary plexus.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2023.1161942","type":"journal-article","created":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T05:15:21Z","timestamp":1685596521000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Inter-examiner and intra-examiner reliability of optical coherence tomography angiography in vascular density measurement of retinal and choriocapillaris plexuses in healthy children aged 6\u201315 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