{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:29:45Z","timestamp":1793312985611,"version":"4.5.0"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T00:00:00Z","timestamp":1684886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001842","name":"Department of Higher Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001842","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Hepatitis B virus (HBV) infection is a major health threat worldwide, especially in developing countries. We aimed to investigate the impact of hepatitis B carrier on pregnancy complications in pregnant women, in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study was conducted by using data from the EHR system of Longhua District People\u2019s Hospital in Shenzhen, China, from January 2018 to June 2022. Binary logistic regression was used to evaluate the relationship between HBsAg carrier status and pregnancy complications and pregnancy outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 2095 HBsAg carriers (exposed group) and 23,019 normal pregnant women (unexposed group). Pregnant women in the exposed group were older than the pregnant women in the unexposed group (29 (27,32) vs. 29 (26,32), <jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001). In addition, the incidence of some adverse pregnancy complications in the exposure group was lower than that in the unexposed group, including hypothyroidism of pregnancy (adjusted odds ratio [aOR], 0.779; 95% confidence interval [CI], 0.617\u20130.984; <jats:italic>p<\/jats:italic>\u2009=\u20090.036), hyperthyroidism of pregnancy (aOR, 0.388; 95% CI, 0.159\u20130.984; <jats:italic>p<\/jats:italic>\u2009=\u20090.038), pregnancy induced hypertension (aOR, 0.699; 95% CI, 0.551\u20130.887; <jats:italic>p<\/jats:italic>\u2009=\u20090.003), antepartum hemorrhage (aOR, 0.294; 95% CI, 0.093\u20130.929; <jats:italic>p<\/jats:italic>\u2009=\u20090.037). However, compared with the unexposed group, the exposed group had a higher risk of lower birth weight (aOR, 1.12; 95% CI, 1.02\u20131.23; <jats:italic>p<\/jats:italic>\u2009=\u20090.018) and intrahepatic cholestasis of pregnancy (aOR, 2.888, 95% CI, 2.207\u20133.780; <jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence rate of HBsAg carriers in pregnant women in Longhua District of Shenzhen was 8.34%. Compared with normal pregnant women, HBsAg carriers have a higher risk of ICP, a lower risk of gestational hypothyroidism and PIH, and a lower birth weight of their infants.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2023.1166530","type":"journal-article","created":{"date-parts":[[2023,5,24]],"date-time":"2023-05-24T13:46:22Z","timestamp":1684935982000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Effects of HBsAg carriers on pregnancy complications in pregnant women: a retrospective cohort 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to 2030: eliminating hepatitis B disease","volume":"97","author":"Liu","year":"2019","journal-title":"China Bull World Health Organ"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/j.ijid.2022.06.017","article-title":"Trends in the disease burden of HBV and HCV infection in China from 1990-2019","volume":"122","author":"Yue","year":"2022","journal-title":"Int J Infect Dis"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"100267","DOI":"10.1016\/j.lanwpc.2021.100267","article-title":"Hepatitis B virus infection among 90 million pregnant women in 2853 Chinese counties, 2015-2020: a national observational study","volume":"16","author":"Liu","year":"2021","journal-title":"Lancet Reg Health West Pac"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1080\/14740338.2016.1211106","article-title":"Prophylaxis of vertical HBV infection","volume":"15","author":"Pawlowska","year":"2016","journal-title":"Expert Opin Drug 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