{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:00:35Z","timestamp":1753891235825,"version":"3.41.2"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T00:00:00Z","timestamp":1688428800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Ewing sarcomas (EWS) are highly malignant neoplasms of mesenchymal origin that are rare in the head and neck. Only a few laryngeal EWS have been reported in the literature. We report a 47\u2009years-old man who visited our hospital for medical help after 5\u2009months of hoarseness and sore throat. Computed tomography (CT) showed uneven thickening of the epiglottis fold, right vocal cord, and anterior union. In addition, fluoro-18-fluorodeoxyglucose positron emission tomography (<jats:sup>18<\/jats:sup>F-FDG PET)\/CT has confirmed high activity in the already known laryngeal and nodal lesions, and has revealed otherwise unknown skeletal metastases. We also reviewed the published clinical features, histopathology, and imaging findings of nine patients with laryngeal EWS confirmed by pathology. The main clinical manifestations of laryngeal EWS are rapidly growing lumps, hoarseness, acute respiratory distress, and aphonia. The EWS tumor cells usually express CD99, vimentin, synaptophysin (Syn), and neuron-specific enolase (NSE) but do not express common antigen (LCA), CD20, and chromaffin granin (CgA). Laryngeal EWS\u2019 CT imaging characteristics are mainly homogeneous, well-bounded soft-tissue masses. Our case suggests that EWS should be considered a differential diagnosis of laryngeal cancer, especially when PET\/CT reveals distant bone metastasis, which is more likely to indicate EWS.<\/jats:p>","DOI":"10.3389\/fmed.2023.1167350","type":"journal-article","created":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T15:23:44Z","timestamp":1688484224000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Fluoro-18-fluorodeoxyglucose positron emission tomography\/computed tomography detects Ewing\u2019s sarcoma of the larynx with multiple distant bone metastases: a case report and literature review"],"prefix":"10.3389","volume":"10","author":[{"given":"Xianwen","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dandan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiong","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,7,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1007\/s00066-013-0356-8","article-title":"Ewing\u2019s sarcoma of the larynx. Effective treatment with organ preservation","volume":"189","author":"Wygoda","year":"2013","journal-title":"Strahlenther Onkol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1056\/NEJMra2028910","article-title":"Ewing\u2019s sarcoma","volume":"384","author":"Riggi","year":"2021","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1016\/j.bjps.2006.01.046","article-title":"Extraskeletal Ewing\u2019s sarcoma of the submandibular gland","volume":"60","author":"Agir","year":"2007","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"e32189","DOI":"10.1097\/MD.0000000000032189","article-title":"Experience of CT diagnosis and management of primary renal Ewing\u2019s sarcoma: a retrospective analysis of 6 cases and a literature review","volume":"101","author":"Hu","year":"2022","journal-title":"Medicine"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1035800","DOI":"10.3389\/fonc.2022.1035800","article-title":"Case report: primary intracranial EWs\/PNET in adults: clinical experience and literature review","volume":"12","author":"Hu","year":"2022","journal-title":"Front Oncol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"574","DOI":"10.3747\/co.26.5001","article-title":"Primary Ewing sarcoma of the larynx with distant metastasis: a case report and review of the literature","volume":"26","author":"Maroun","year":"2019","journal-title":"Curr Oncol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1726","DOI":"10.1002\/1097-0142(19830501)51:9<1726::aid-cncr2820510928>3.0.co;2-w","article-title":"Sarcoma of the larynx in a newborn","volume":"51","author":"Abramowsky","year":"1983","journal-title":"Cancer"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1001\/archotol.1995.01890120050009","article-title":"Peripheral primitive neuroectodermal tumors of the head and neck","volume":"121","author":"Jones","year":"1995","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1258\/002221504322731682","article-title":"Extraskeletal Ewing\u2019s sarcoma of the larynx","volume":"118","author":"Yang","year":"2004","journal-title":"J Laryngol Otol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.3892\/ol.2015.4013","article-title":"A peripheral primitive neuroectodermal tumor in the larynx: a case report and literature review","volume":"11","author":"Ijichi","year":"2016","journal-title":"Oncol Lett"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/s12105-013-0492-6","article-title":"Extraskeletal Ewing\u2019s sarcoma arising in the larynx","volume":"8","author":"Lynch","year":"2014","journal-title":"Head Neck Pathol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1003393","DOI":"10.3389\/fonc.2022.1003393","article-title":"Laryngeal extraskeletal Ewing sarcoma treated with DC-CTL immunotherapy: a case report and review of the literature","volume":"12","author":"Wang","year":"2022","journal-title":"Front Oncol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"65","DOI":"10.5152\/tao.2020.4839","article-title":"Ewing sarcoma of larynx: a rare case in a 5-year-old boy","volume":"58","author":"Pasha","year":"2020","journal-title":"Turk Arch Otorhinolaryngol"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.ijporl.2018.11.026","article-title":"Pediatric Ewing sarcoma of the head and neck: a retrospective survival analysis","volume":"117","author":"Martin","year":"2019","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.jbo.2018.04.002","article-title":"Trends in incidence of Ewing sarcoma of bone in India\u2014evidence from the National Cancer Registry Programme (1982\u20132011)","volume":"12","author":"Chakraborty","year":"2018","journal-title":"J Bone Oncol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"NP203","DOI":"10.1177\/0145561320953696","article-title":"Extraosseous Ewing sarcoma of the cervical esophagus: case report and literature review","volume":"101","author":"Wang","year":"2022","journal-title":"Ear Nose Throat J"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1093\/jjco\/hys027","article-title":"Extraskeletal Ewing\u2019s sarcoma family of tumors in adults: prognostic factors and clinical outcome","volume":"42","author":"Tural","year":"2012","journal-title":"Jpn J Clin Oncol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1007\/s00256-022-04182-7","article-title":"Molecular imaging of sarcomas with FDG PET","volume":"52","author":"Mendoza","year":"2022","journal-title":"Skelet Radiol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"857","DOI":"10.3760\/cma.j.issn.1673-0860.2017.11.014","article-title":"PET-CT suggested laryngeal cancer with bone metastasis but diagnosed with multiple myeloma","volume":"52","author":"Zhao","year":"2017","journal-title":"Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1200\/JCO.2017.74.7402","article-title":"Rhabdomyosarcoma, Ewing sarcoma, and other round cell sarcomas","volume":"36","author":"Pappo","year":"2018","journal-title":"J Clin Oncol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.canep.2014.12.012","article-title":"Prognostic factors for survival in patients with Ewing\u2019s sarcoma using the surveillance, epidemiology, and end results (SEER) program database","volume":"39","author":"Duchman","year":"2015","journal-title":"Cancer Epidemiol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"3084","DOI":"10.1245\/s10434-022-12992-1","article-title":"Prognostic factors and clinical outcomes in extraskeletal Ewing sarcoma: a cohort study","volume":"30","author":"Mathew","year":"2022","journal-title":"Ann Surg Oncol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1002\/pbc.25830","article-title":"Management and outcome of Ewing sarcoma of the head and neck","volume":"63","author":"Grevener","year":"2016","journal-title":"Pediatr Blood Cancer"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1159\/000475806Data","article-title":"Systemic therapy outcomes in adult patients with Ewing sarcoma family of tumors","volume":"10","author":"Valdes","year":"2017","journal-title":"Case Rep Oncol"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2023.1167350\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T15:23:54Z","timestamp":1688484234000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2023.1167350\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,4]]},"references-count":24,"alternative-id":["10.3389\/fmed.2023.1167350"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2023.1167350","relation":{},"ISSN":["2296-858X"],"issn-type":[{"type":"electronic","value":"2296-858X"}],"subject":[],"published":{"date-parts":[[2023,7,4]]},"article-number":"1167350"}}