{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T09:26:51Z","timestamp":1792402011766,"version":"4.4.0"},"reference-count":195,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T00:00:00Z","timestamp":1685404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Many eye diseases, such as diabetic retinopathy (DR), age-related macular degeneration (AMD), and cataracts are preventable and treatable with lifestyle. The objective of this review is to assess the most recent research on the ideal dietary approach to prevent or support the treatment of DR, AMD, and cataracts, as well as to construct a food pyramid that makes it simple for people who are at risk of developing these pathologies to decide what to eat. The food pyramid presented here proposes what should be consumed every day: 3 portions of low glycemic index (GI) grains (for fiber and zinc content), 5 portions (each portion: \u2265200 g\/day) of fruits and vegetables (spinach, broccoli, zucchini cooked, green leafy vegetables, orange, kiwi, grapefruit for folic acid, vitamin C, and lutein\/zeaxanthin content, at least \u226542 \u03bcg\/day, are to be preferred), extra virgin olive (EVO) oil (almost 20 mg\/day for vitamin E and polyphenols content), nuts or oil seeds (20\u201330 g\/day, for zinc content, at least \u226515.8 mg\/day); weekly: fish (4 portions, for omega-3 content and eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA) 0.35\u20131.4 g\/day), white meat (3 portions for vitamin B12 content), legumes (2 portions for vegetal proteins), eggs (2 portions for lutein\/zeaxanthin content), light cheeses (2 portions for vitamin B6 content), and almost 3\u20134 times\/week microgreen and spices (saffron and curcumin). At the top of the pyramid, there are two pennants: one green, which indicates the need for personalized supplementation (if daily requirements cannot be met through diet, omega-3, and L-methylfolate supplementation), and one red, which indicates that certain foods are prohibited (salt and sugar). Finally, 3\u20134 times per week, 30\u201340 min of aerobic and resistance exercises are required.<\/jats:p>","DOI":"10.3389\/fmed.2023.1168560","type":"journal-article","created":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T12:33:56Z","timestamp":1685536436000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":25,"title":["Diet and ideal food pyramid to prevent or support the treatment of diabetic retinopathy, age-related macular degeneration, and cataracts"],"prefix":"10.3389","volume":"10","author":[{"given":"Mariangela","family":"Rondanelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Gasparri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Riva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Petrangolini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetan Claude","family":"Barrile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Cavioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Razza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Tartara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Perna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,5,30]]},"reference":[{"key":"B1","volume-title":"World Report on Vision","year":"2019"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1038\/s41433-018-0081-8","article-title":"Physical activity, visual impairment, and eye disease","volume":"32","author":"Ong","year":"2018","journal-title":"Eye."},{"key":"B3","doi-asserted-by":"publisher","first-page":"2862","DOI":"10.3390\/nu12092862","article-title":"Dietary patterns, carbohydrates, and age-related eye diseases","volume":"12","author":"Francisco","year":"2020","journal-title":"Nutrients."},{"key":"B4","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/S0197-2456(99)00031-8","volume":"20","year":"1999","journal-title":"Control Clin Trials."},{"key":"B5","first-page":"2005","volume-title":"JAMA.","year":"2013"},{"key":"B6","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.preteyeres.2015.10.003","article-title":"Lutein, zeaxanthin, and meso-zeaxanthin: the basic and clinical science underlying carotenoid-based nutritional interventions against ocular disease","volume":"50","author":"Bernstein","year":"2016","journal-title":"Prog Retin Eye Res."},{"key":"B7","first-page":"1795","article-title":"Dietary modification of human macular pigment density","volume":"38","author":"Hammond","year":"1997","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.abb.2006.09.032","article-title":"Xanthophyll accumulation in the human retina during supplementation with lutein or zeaxanthin \u2013 the LUXEA (LUtein Xanthophyll Eye Accumulation) study","volume":"458","author":"Schalch","year":"2007","journal-title":"Arch Biochem Biophys."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1093\/ajcn\/87.5.1521","article-title":"The influence of supplemental lutein and docosahexaenoic acid on serum, lipoproteins, and macular pigmentation","volume":"87","author":"Johnson","year":"2008","journal-title":"Am J Clin Nutr."},{"key":"B10","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1006\/exer.1997.0309","article-title":"A one year study of the macular pigment: the effect of 140 days of a lutein supplement","volume":"65","author":"Landrum","year":"1997","journal-title":"Exp Eye Res."},{"key":"B11","doi-asserted-by":"publisher","first-page":"120","DOI":"10.3390\/nu9020120","article-title":"Lutein and zeaxanthin\u2014food sources, bioavailability and dietary variety in age-related macular degeneration protection","volume":"9","author":"Eisenhauer","year":"2017","journal-title":"Nutrients."},{"key":"B12","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.jfca.2008.07.006","article-title":"Xanthophyll (lutein, zeaxanthin) content in fruits, vegetables and corn and egg products","volume":"22","author":"Perry","year":"2009","journal-title":"J Food Compos Anal."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1002\/jsfa.6478","article-title":"The effect of cooking on the phytochemical content of vegetables","volume":"94","author":"Palermo","year":"2014","journal-title":"J Sci Food Agric."},{"key":"B14","doi-asserted-by":"publisher","first-page":"7644","DOI":"10.1021\/jf300459b","article-title":"Assessment of vitamin and carotenoid concentrations of emerging food products: edible microgreens","volume":"60","author":"Xiao","year":"2012","journal-title":"J Agric Food Chem."},{"key":"B15","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/0002-8223(93)91553-3","article-title":"Carotenoid content of fruits and vegetables: an evaluation of analytic data","volume":"93","author":"Mangels","year":"1993","journal-title":"J Am Diet Assoc."},{"key":"B16","doi-asserted-by":"publisher","first-page":"608","DOI":"10.3382\/ps.0670608","article-title":"Carotenoid composition of serum and egg yolks of hens fed diets varying in carotenoid composition","volume":"67","author":"Schaeffer","year":"1988","journal-title":"Poult Sci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"240","DOI":"10.2174\/157340108786263685","article-title":"Bioavailability of non-provitamin A carotenoids","volume":"4","author":"Bohn","year":"2008","journal-title":"Curr Nutr Food Sci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1093\/jn\/130.3.503","article-title":"dietary factors that affect the bioavailability of carotenoids","volume":"130","author":"van het Hof","year":"2000","journal-title":"J Nutr."},{"key":"B19","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.nutres.2007.04.002","article-title":"Xanthophyll carotenoids are more bioaccessible from fruits than dark green vegetables","volume":"27","author":"O'Connell","year":"2007","journal-title":"Nutr Res."},{"key":"B20","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1093\/jn\/129.2.349","article-title":"The food matrix of spinach is a limiting factor in determining the bioavailability of \u03b2-carotene and to a lesser extent of lutein in humans","volume":"129","author":"Castenmiller","year":"1999","journal-title":"J Nutr."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.3390\/nu13051703","article-title":"Vitamin a update: forms, sources, kinetics, detection, function, deficiency, therapeutic use and toxicity","volume":"13","author":"Carazo","year":"2021","journal-title":"Nutrients."},{"key":"B22","doi-asserted-by":"publisher","first-page":"2069","DOI":"10.3390\/nu4122069","article-title":"Retina, retinol, retinal and the natural history of vitamin A as a light sensor","volume":"4","author":"Zhong","year":"2012","journal-title":"Nutrients."},{"key":"B23","doi-asserted-by":"publisher","first-page":"d5094","DOI":"10.1136\/bmj.d5094","article-title":"Vitamin A supplements for preventing mortality, illness, and blindness in children aged under 5: systematic review and meta-analysis","volume":"343","author":"Mayo-Wilson","year":"2011","journal-title":"BMJ."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1093\/jn\/131.6.1647","article-title":"The discovery of the visual function of vitamin A","volume":"131","author":"Wolf","year":"2001","journal-title":"J Nutr."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1016\/j.nut.2014.02.025","article-title":"Association of vitamin A and \u03b2-carotene with risk for age-related cataract: a meta-analysis","volume":"30","author":"Wang","year":"2014","journal-title":"Nutrition."},{"key":"B26","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1093\/ajcn\/nqy270","article-title":"Dietary vitamin and carotenoid intake and risk of age-related cataract","volume":"109","author":"Jiang","year":"2019","journal-title":"Am J Clin Nutr."},{"key":"B27","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1093\/oxfordjournals.aje.a115023","article-title":"Factors associated with age-related macular degeneration. An analysis of data from the first National Health and Nutrition Examination Survey","volume":"128","author":"Goldberg","year":"1988","journal-title":"Am J Epidemiol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1001\/archopht.117.10.1384","article-title":"Age-related macular degeneration and antioxidant status in the POLA study. POLA Study Group. Pathologies Oculaires Li\u00e9es \u00e0 l'Age","volume":"117","author":"Delcourt","year":"1999","journal-title":"Arch Ophthalmol."},{"key":"B29","doi-asserted-by":"crossref","first-page":"p. 487","DOI":"10.1002\/9780470693926","volume-title":"Systematic Reviews in Health Care : Meta-Analysis in Context","author":"Egger","year":"2001"},{"key":"B30","doi-asserted-by":"publisher","first-page":"2134","DOI":"10.2337\/dc15-1117","article-title":"Mediterranean diet, retinopathy, nephropathy, and microvascular diabetes complications: a post hoc analysis of a randomized trial","volume":"38","author":"Diaz-Lopez","year":"2015","journal-title":"Diabetes Care."},{"key":"B31","doi-asserted-by":"publisher","first-page":"14","DOI":"10.2337\/dc10-1288","article-title":"Reduction in the incidence of type 2 diabetes with the Mediterranean DietResults of the PREDIMED-Reus nutrition intervention randomized trial","volume":"34","author":"Salas-Salvad\u00f3","year":"2011","journal-title":"Diabetes Care."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1001\/jamaophthalmol.2016.2906","article-title":"Dietary marine \u03c9-3 fatty acids and incident sight-threatening retinopathy in middle-aged and older individuals with type 2 diabetes: prospective investigation from the PREDIMED trial","volume":"134","author":"Sala-Vila","year":"2016","journal-title":"JAMA Ophthalmol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s41043-017-0115-z","article-title":"Association of dietary patterns with diabetes complications among type 2 diabetes patients in Gaza Strip, Palestine: a cross sectional study","volume":"36","author":"el Bilbeisi","year":"2017","journal-title":"J Health Popul Nutr."},{"key":"B34","doi-asserted-by":"crossref","unstructured":"TanakaS\n            YoshimuraY\n            KawasakiR\n          23348071JSTORFruit intake incident diabetic retinopathy with type 2 diabetes2013","DOI":"10.1097\/EDE.0b013e318281725e"},{"key":"B35","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1093\/ajcn\/76.1.93","article-title":"Fruit and vegetable intake and risk of cardiovascular disease in US adults: the first National Health and Nutrition Examination Survey Epidemiologic Follow-up Study","volume":"76","author":"Bazzano","year":"2002","journal-title":"Am J Clin Nutr."},{"key":"B36","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1093\/ajcn\/nqz328","article-title":"Effect of a 2-year diet intervention with walnuts on cognitive decline. The Walnuts And Healthy Aging (WAHA) study: a randomized controlled trial","volume":"111","author":"Sala-Vila","year":"2020","journal-title":"Am J Clin Nutr."},{"key":"B37","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.nut.2017.12.010","article-title":"Adherence to a Mediterranean diet and its association with age-related macular degeneration. The Coimbra Eye Study\u2013Report 4","volume":"2","author":"Nunes","year":"2018","journal-title":"Nutrition."},{"key":"B38","doi-asserted-by":"publisher","first-page":"231570","DOI":"10.1155\/2015\/231570","article-title":"Regular Chinese green tea consumption is protective for diabetic retinopathy: a clinic-based case-control study","volume":"2015","author":"Ma","year":"2015","journal-title":"J Diabetes Res."},{"key":"B39","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1097\/EDE.0b013e31821083e3","article-title":"Boiled coffee intake and subsequent risk for type 2 diabetes","volume":"22","author":"Hjellvik","year":"2011","journal-title":"Epidemiology."},{"key":"B40","unstructured":"TuomilehtoJ\n            HuG\n            BidelS\n            Lindstr\u00f6mJ\n          10.1001\/jama.291.10.121315010442Coffee consumption and risk of type 2 diabetes mellitus among middle-aged Finnish men and women"},{"key":"B41","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1017\/S0007114508006545","article-title":"Plasma carotenoids and diabetic retinopathy","volume":"101","author":"Brazionis","year":"2008","journal-title":"Br J Nutr."},{"key":"B42","doi-asserted-by":"publisher","first-page":"637","DOI":"10.5301\/EJO.2010.6212","article-title":"A 5-year follow-up of antioxidant supplementation in type 2 diabetic retinopathy","volume":"21","author":"Garcia-Medina","year":"2011","journal-title":"Eur J Ophthalmol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"406","DOI":"10.6133\/APJCN.032016.13","article-title":"Effect of lutein supplementation on visual function in nonproliferative diabetic retinopathy","volume":"26","author":"Zhang","year":"2017","journal-title":"Asia Pac J Clin Nutr."},{"key":"B44","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s40662-017-0088-4","article-title":"Effect of carotenoids dietary supplementation on macular function in diabetic patients","volume":"4","author":"Moschos","year":"2017","journal-title":"Eye Vis."},{"key":"B45","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1093\/ajcn\/79.5.865","article-title":"Relation between intake of vitamins C and E and risk of diabetic retinopathy in the Atherosclerosis Risk in Communities Study","volume":"79","author":"Millen","year":"2004","journal-title":"Am J Clin Nutr."},{"key":"B46","doi-asserted-by":"publisher","first-page":"2264","DOI":"10.1016\/S0161-6420(98)91227-1","article-title":"Antioxidant nutrient intake and diabetic retinopathy: the San Luis Valley Diabetes Study","volume":"105","author":"Mayer-Davis","year":"","journal-title":"Ophthalmology"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12933-016-0434-1","article-title":"Adequate vitamin D status is associated with the reduced odds of prevalent diabetic retinopathy in African Americans and Caucasians","volume":"15","author":"Millen","year":"2016","journal-title":"Cardiovasc Diabetol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"e281","DOI":"10.1038\/nutd.2017.30","article-title":"Glycated hemoglobin A1C and vitamin D and their association with diabetic retinopathy severity","volume":"7","author":"Long","year":"2017","journal-title":"Nutr Diab."},{"key":"B49","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/j.jdiacomp.2014.06.011","article-title":"Influence of flavonoid-rich fruit and vegetable intake on diabetic retinopathy and diabetes-related biomarkers","volume":"28","author":"Mahoney","year":"2014","journal-title":"J Diabetes Complic."},{"key":"B50","doi-asserted-by":"publisher","first-page":"e0218433","DOI":"10.1371\/journal.pone.0218433","article-title":"Association of vitreous vitamin C depletion with diabetic macular ischemia in proliferative diabetic retinopathy","volume":"14","author":"Park","year":"2019","journal-title":"PLoS ONE."},{"key":"B51","doi-asserted-by":"publisher","first-page":"S23","DOI":"10.3928\/23258160-20190108-06","article-title":"Role of statins and ascorbic acid in the natural history of diabetic retinopathy: a new, affordable therapy?","volume":"50","author":"Gurreri","year":"2019","journal-title":"Ophthalmic Surg Lasers Imaging Retina."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.12659\/MSM.893192","article-title":"Antioxidant vitamin C prevents decline in endothelial function during sitting","volume":"21","author":"Thosar","year":"2015","journal-title":"Med Sci Monitor."},{"key":"B53","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1620\/tjem.212.247","article-title":"High serum homocysteine levels correlate with a decrease in the blood flow velocity of the ophthalmic artery in highway toll collectors","volume":"212","author":"Memisogullari","year":"2007","journal-title":"Tohoku J Exp Med."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1007\/s00394-019-02014-4","article-title":"Vitamin B6 intake and incidence of diabetic retinopathy in Japanese patients with type 2 diabetes: analysis of data from the Japan Diabetes Complications Study (JDCS)","volume":"59","author":"Horikawa","year":"2020","journal-title":"Eur J Nutr."},{"key":"B55","doi-asserted-by":"publisher","first-page":"129","DOI":"10.3945\/ajcn.112.057091","article-title":"Homocysteine, folate, vitamin B-12, and 10-y incidence of age-related macular degeneration","volume":"98","author":"Gopinath","year":"2013","journal-title":"Am J Clin Nutr."},{"key":"B56","doi-asserted-by":"publisher","first-page":"7473","DOI":"10.1167\/iovs.15-17485","article-title":"The associations of dietary intake of polyunsaturated fatty acids with diabetic retinopathy in well-controlled diabetes","volume":"56","author":"Sasaki","year":"2015","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"B57","first-page":"584","article-title":"Effect of alpha-lipoic acid on blood glucose, insulin resistance and glutathione peroxidase of type 2 diabetic patients","volume":"32","author":"Ansar","year":"2011","journal-title":"Saudi Med J."},{"key":"B58","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1111\/j.1365-2265.2007.03099.x","article-title":"The antioxidant alpha-lipoic acid improves endothelial dysfunction induced by acute hyperglycaemia during OGTT in impaired glucose tolerance","volume":"68","author":"Xiang","year":"2008","journal-title":"Wiley Online Library."},{"key":"B59","doi-asserted-by":"publisher","first-page":"3276","DOI":"10.4103\/0366-6999.171357","article-title":"Relationship between serum zinc level and microvascular complications in patients with type 2 diabetes","volume":"128","author":"Luo","year":"2015","journal-title":"Chin Med J."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1023747","DOI":"10.3389\/fpubh.2022.1023747","article-title":"Lower hydration status increased diabetic retinopathy among middle-aged adults and older adults: results from NHANES 2005-2008","volume":"10","author":"Zhang","year":"2022","journal-title":"Front Public Health."},{"key":"B61","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/j.jdiacomp.2016.06.027","article-title":"Physical activity and its correlation to diabetic retinopathy","volume":"31","author":"Praidou","year":"2017","journal-title":"J Diabetes Complic."},{"key":"B62","doi-asserted-by":"publisher","first-page":"e0239214","DOI":"10.1371\/journal.pone.0239214","article-title":"Effect of physical activity on reducing the risk of diabetic retinopathy progression: 10-year prospective findings from the 45 and Up Study","volume":"16","author":"Yan","year":"2021","journal-title":"PLoS ONE."},{"key":"B63","doi-asserted-by":"publisher","first-page":"e0172890","DOI":"10.1371\/journal.pone.0172890","article-title":"Higher levels of physical activity are independently associated with a lower incidence of diabetic retinopathy in Japanese patients with type 2 diabetes: a prospective cohort study, Diabetes Distress and Care Registry at Tenri (DDCRT15)","volume":"12","author":"Kuwata","year":"2017","journal-title":"PLoS ONE."},{"key":"B64","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1186\/1471-2431-12-92","article-title":"Effect of physical activity and sun exposure on vitamin D status of Saudi children and adolescents","volume":"12","author":"Al-Othman","year":"2012","journal-title":"BMC Pediatr."},{"key":"B65","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1111\/j.1365-2265.2010.03858.x","article-title":"A prospective study of the associations between 25-hydroxy-vitamin D, sarcopenia progression and physical activity in older adults","volume":"73","author":"Scott","year":"2010","journal-title":"Clin Endocrinol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1136\/jech-2014-204632","article-title":"Objectively measured physical activity and vitamin D status in older people from Germany","volume":"69","author":"Klenk","year":"2015","journal-title":"J Epidemiol Community Health."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1017\/S000711451400186X","article-title":"Vitamin D status and predictors of serum 25-hydroxyvitamin D concentrations in Western Australian adolescents","volume":"112","author":"Black","year":"2014","journal-title":"Br J Nutr."},{"key":"B68","doi-asserted-by":"publisher","first-page":"521","DOI":"10.2337\/dc14-0180","article-title":"Serum 25-hydroxyvitamin d: a predictor of macrovascular and microvascular complications in patients with type 2 diabetes","volume":"38","author":"Herrmann","year":"2015","journal-title":"Diabetes Care."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1800","DOI":"10.2337\/diacare.15.11.1800","article-title":"Ten-year experience with an exercise-based outpatient life-style modification program in the treatment of diabetes mellitus","volume":"15","author":"Schneider","year":"1992","journal-title":"Diabetes Care."},{"key":"B70","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1007\/s10654-017-0338-8","article-title":"Diet and risk of diabetic retinopathy: a systematic review","volume":"33","author":"Dow","year":"2018","journal-title":"Eur J Epidemiol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"e0186582","DOI":"10.1371\/journal.pone.0186582","article-title":"Dietary intake and diabetic retinopathy: a systematic review","volume":"13","author":"Wong","year":"2018","journal-title":"PLoS ONE."},{"key":"B72","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1097\/MCO.0000000000000508","article-title":"Beneficial effects of walnut consumption on human health: role of micronutrients","volume":"21","author":"Ros","year":"2018","journal-title":"Curr Opin Clin Nutr Metab Care."},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.3945\/jn.113.184838","article-title":"Role of walnuts in maintaining brain health with age","author":"Poulose","year":"2014","journal-title":"J Nutr."},{"key":"B74","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.3390\/foods10061231","article-title":"Searching for the antioxidant, anti-inflammatory, and neuroprotective potential of natural food and nutritional supplements for ocular health in the mediterranean","volume":"10","author":"Valero-Vello","year":"2021","journal-title":"Foods."},{"key":"B75","doi-asserted-by":"publisher","first-page":"170","DOI":"10.3390\/antiox8060170","article-title":"Effects and mechanisms of tea for the prevention and management of diabetes mellitus and diabetic complications: an updated review","volume":"8","author":"Meng","year":"2019","journal-title":"Antioxidants."},{"key":"B76","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1111\/j.1753-4887.2012.00470.x","article-title":"Role of coffee in modulation of diabetes risk","volume":"70","author":"Natella","year":"2012","journal-title":"Nutr Rev."},{"key":"B77","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.nut.2013.11.020","article-title":"Effects of coffee on type 2 diabetes mellitus","volume":"30","author":"Akash","year":"2014","journal-title":"Nutrition."},{"key":"B78","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1093\/nutrit\/nuy014","article-title":"Coffee consumption and reduced risk of developing type 2 diabetes: a systematic review with meta-analysis","volume":"76","author":"Carlstr\u00f6m","year":"2018","journal-title":"Nutr Rev."},{"key":"B79","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1001\/archopht.124.7.995","article-title":"Cigarette smoking, fish consumption, omega-3 fatty acid intake, and associations with age-related macular degeneration: the US Twin Study of Age-Related Macular Degeneration","volume":"124","author":"Seddon","year":"2006","journal-title":"Arch Ophthalmol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1001\/archopht.124.7.981","article-title":"Dietary fatty acids and the 5-year incidence of age-related maculopathy","volume":"124","author":"Chua","year":"2006","journal-title":"Arch Ophthalmol."},{"key":"B81","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1001\/archophthalmol.2009.76","article-title":"Dietary fatty acids and the 10-year incidence of age-related macular degeneration: the Blue Mountains Eye Study","volume":"127","author":"Tan","year":"2009","journal-title":"Arch Ophthalmol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1001\/archopht.125.9.1225","article-title":"The relationship of dietary carotenoid and vitamin A, E, and C intake with age-related macular degeneration in a case-control study: AREDS Report No","volume":"125","author":"SanGiovanni","year":"2007","journal-title":"Arch Ophthalmol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"720","DOI":"10.3129\/i07-116","article-title":"Dietary lutein, zeaxanthin, and fats and the progression of age-related macular degeneration","volume":"42","author":"Robman","year":"2007","journal-title":"Can J Ophthalmol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1038\/sj.ejcn.1602685","article-title":"Dietary fat and the risk of age-related maculopathy: the POLANUT study","volume":"61","author":"Delcourt","year":"2007","journal-title":"Eur J Clin Nutr."},{"key":"B85","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1001\/archopht.119.8.1191","article-title":"Dietary fat and risk for advanced age-related macular degeneration","volume":"119","author":"Seddon","year":"2001","journal-title":"Arch Ophthalmol."},{"key":"B86","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1136\/bjo.2008.143412","article-title":"Does eating particular diets alter the risk of age-related macular degeneration in users of the Age-Related Eye Disease Study supplements?","volume":"93","author":"Chiu","year":"2009","journal-title":"Br J Ophthalmol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1001\/jama.272.18.1413","article-title":"Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. Eye Disease Case-Control Study Group","volume":"272","author":"Seddon","year":"1994","journal-title":"JAMA."},{"key":"B88","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1034\/j.1600-0420.2002.800404.x","article-title":"Neovascular age-related macular degeneration and its relationship to antioxidant intake","volume":"80","author":"Snellen","year":"2002","journal-title":"Acta Ophthalmol Scand."},{"key":"B89","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/S0009-8981(02)00056-6","article-title":"Serum oxidative and antioxidant parameters in a group of Italian patients with age-related maculopathy","volume":"320","author":"Simonelli","year":"2002","journal-title":"Clinica Chimica Acta."},{"key":"B90","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1001\/archopht.119.10.1417","article-title":"A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no","volume":"119","author":"Kassoff","year":"2001","journal-title":"Arch Ophthalmol."},{"key":"B91","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1016\/j.ophtha.2007.09.011","article-title":"Supplements and age-related eye conditions the beaver dam eye study","volume":"115","author":"Klein","year":"2008","journal-title":"Ophthalmology."},{"key":"B92","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.3945\/ajcn.115.111047","article-title":"Adherence to a Mediterranean diet, genetic susceptibility, and progression to advanced macular degeneration: a prospective cohort study 1-3","volume":"102","author":"Merle","year":"2015","journal-title":"Am J Clin Nutr."},{"key":"B93","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.ajo.2018.09.036","article-title":"Intake of vegetables, fruit, and fish is beneficial for age-related macular degeneration","volume":"198","author":"de Koning-Backus","year":"2019","journal-title":"Am J Ophthalmol."},{"key":"B94","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.1167\/iovs.16-20454","article-title":"Visualization of dietary patterns and their associations with age-related macular degeneration","volume":"58","author":"Chiu","year":"2017","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"B95","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1016\/j.ophtha.2014.01.002","article-title":"Dietary patterns and their associations with age-related macular degeneration: the Melbourne collaborative cohort study","volume":"121","author":"Amirul Islam","year":"2014","journal-title":"Ophthalmology."},{"key":"B96","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1093\/ajcn\/81.6.1417","article-title":"Fruit and vegetable intake and the risk of cataract in women","volume":"81","author":"Christen","year":"2005","journal-title":"Am J Clin Nutr."},{"key":"B97","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1001\/archopht.119.7.1009","article-title":"Long-term nutrient intake and early age-related nuclear lens opacities","volume":"119","author":"Jacques","year":"2001","journal-title":"Arch Ophthalmol."},{"key":"B98","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.1093\/jn\/134.7.1812","article-title":"Overall adherence to the dietary guidelines for Americans is associated with reduced prevalence of early age-related nuclear lens opacities in women","volume":"134","author":"Moeller","year":"2004","journal-title":"J Nutr."},{"key":"B99","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1093\/jn\/132.6.1299","article-title":"Vitamin C is associated with reduced risk of cataract in a Mediterranean population","volume":"132","author":"Pastor-Valero","year":"2002","journal-title":"J Nutr."},{"key":"B100","doi-asserted-by":"publisher","first-page":"e22490","DOI":"10.5812\/ircmj.22490","article-title":"Healthy eating index in patients with cataract: a case-control study","volume":"17","author":"Ghanavati","year":"2015","journal-title":"Iran Red Crescent Med J."},{"key":"B101","doi-asserted-by":"publisher","first-page":"586","DOI":"10.18240\/ijo.2017.04.14","article-title":"Nutrient patterns and risk of cataract: a case-control study","volume":"10","author":"Sedaghat","year":"2017","journal-title":"Int J Ophthalmol."},{"key":"B102","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1136\/bjo.73.2.100","article-title":"Dehydrational crises: a major risk factor in blinding cataract","volume":"73","author":"Minassian","year":"1989","journal-title":"Br J Ophthalmol."},{"key":"B103","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/j.ophtha.2008.01.033","article-title":"Multivitamin Supplements and cataract prevention","volume":"115","author":"Chong","year":"2008","journal-title":"Ophthalmology."},{"key":"B104","doi-asserted-by":"publisher","first-page":"643","DOI":"10.18240\/ijo.2020.04.18","article-title":"Physical activity and risk of age-related cataract","volume":"13","author":"Jiang","year":"2020","journal-title":"Int J Ophthalmol."},{"key":"B105","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1111\/ceo.12546","article-title":"Hydration, fluid regulation and the eye: in health and disease","volume":"43","author":"Sherwin","year":"2015","journal-title":"Clin Exp Ophthalmol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/S0140-6736(09)62124-3","article-title":"Diabetic retinopathy","volume":"376","author":"Cheung","year":"2010","journal-title":"Lancet."},{"key":"B107","doi-asserted-by":"publisher","first-page":"556","DOI":"10.2337\/dc11-1909","article-title":"Global prevalence and major risk factors of diabetic retinopathy","volume":"35","author":"Yau","year":"2012","journal-title":"Diabetes Care"},{"key":"B108","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1007\/s11892-012-0283-6","article-title":"Current epidemiology of diabetic retinopathy and diabetic macular edema","volume":"12","author":"Ding","year":"2012","journal-title":"Curr Diab Rep."},{"key":"B109","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1007\/s00417-017-3608-y","article-title":"Microbial flora and resistance in ophthalmology: a review","volume":"255","author":"Grzybowski","year":"2017","journal-title":"Graefe's Arch Clin Exp Ophthalmol."},{"key":"B110","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/s00592-009-0113-8","article-title":"Association of obesity with diabetic retinopathy: Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetics Study (SN-DREAMS Report no","volume":"47","author":"Raman","year":"2010","journal-title":"Acta Diabetol."},{"key":"B111","doi-asserted-by":"publisher","first-page":"293","DOI":"10.4103\/0974-9233.120007","article-title":"Epidemiological issues in diabetic retinopathy","volume":"20","author":"Scanlon","year":"2013","journal-title":"Middle East Afr J Ophthalmol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.preteyeres.2010.09.001","article-title":"Dietary hyperglycemia, glycemic index and metabolic retinal diseases","volume":"30","author":"Chiu","year":"2011","journal-title":"Prog Retin Eye Res."},{"key":"B113","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.ajo.2005.08.063","article-title":"Diabetic retinopathy in a multi-ethnic cohort in the United States","volume":"141","author":"Wong","year":"2006","journal-title":"Am J Ophthalmol."},{"key":"B114","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1001\/archopht.121.2.245","article-title":"Risk factors for incident retinopathy in a diabetic and nondiabetic population: the Hoorn study","volume":"121","author":"Van Leiden","year":"2003","journal-title":"Arch Ophthalmol."},{"key":"B115","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.jdiacomp.2013.12.008","article-title":"Prevalence and risk factors for diabetic retinopathy in Asian Indians with young onset type 1 and type 2 diabetes","volume":"28","author":"Rajalakshmi","year":"2014","journal-title":"J Diabetes Complic."},{"key":"B116","doi-asserted-by":"publisher","first-page":"2013","DOI":"10.1007\/s00394-017-1406-2","article-title":"Nutrition for diabetic retinopathy: plummeting the inevitable threat of diabetic vision loss","volume":"56","author":"Sharma","year":"2017","journal-title":"Eur J Nutr."},{"key":"B117","unstructured":"A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defects? Elsevier"},{"key":"B118","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.mam.2016.10.002","article-title":"Riboflavin, MTHFR genotype and blood pressure: a personalized approach to prevention and treatment of hypertension","volume":"53","author":"McNulty","year":"2017","journal-title":"Mol Aspects Med."},{"key":"B119","unstructured":"YigitS\n            KarakusN\n            visionAI-M\n          23901246Association of MTHFR gene C677T mutation with diabetic peripheral neuropathy diabetic retinopathy2013"},{"key":"B120","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1002\/jcp.27164","article-title":"A review of the molecular mechanisms of hyperglycemia-induced free radical generation leading to oxidative stress","volume":"234","author":"Yaribeygi","year":"2019","journal-title":"J Cell Physiol."},{"key":"B121","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1161\/CIRCULATIONAHA.107.763730","article-title":"Impaired tissue perfusion","volume":"118","author":"Levy","year":"2008","journal-title":"Circulation."},{"key":"B122","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.2337\/diacare.24.8.1403","article-title":"Fasting plasma homocysteine levels in the insulin resistance syndrome: the Framingham offspring study","volume":"24","author":"Meigs","year":"","journal-title":"Am Diabetes Assoc."},{"key":"B123","doi-asserted-by":"publisher","first-page":"480","DOI":"10.3109\/00498254.2013.845705","article-title":"Folate, folic acid and 5-methyltetrahydrofolate are not the same thing","volume":"44","author":"Scaglione","year":"2014","journal-title":"Xenobiotica."},{"key":"B124","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-017-00034-w","article-title":"Association of alcohol intake with risk of diabetic retinopathy: a meta-analysis of observational studies","volume":"7","author":"Zhu","year":"2017","journal-title":"Sci Rep."},{"key":"B125","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1186\/s12902-020-00588-3","article-title":"Associations between alcohol intake and diabetic retinopathy risk: a systematic review and meta-analysis","volume":"20","author":"Chen","year":"2020","journal-title":"BMC Endocr Disord."},{"key":"B126","doi-asserted-by":"publisher","first-page":"e0139527","DOI":"10.1371\/journal.pone.0139527","article-title":"Prevalence and cardiovascular associations of diabetic retinopathy and maculopathy: results from the Gutenberg health study","volume":"10","author":"Raum","year":"2015","journal-title":"PLoS ONE."},{"key":"B127","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1002\/jcb.23431","article-title":"Cellular and molecular effects of resveratrol in health and disease","volume":"113","author":"Yu","year":"2012","journal-title":"J Cell Biochem."},{"key":"B128","doi-asserted-by":"publisher","first-page":"4422","DOI":"10.1039\/C6FO00372A","article-title":"The antioxidant effect of mulberry and jamun fruit wines by ameliorating oxidative stress in streptozotocin-induced diabetic Wistar rats","volume":"7","author":"Srikanta","year":"2016","journal-title":"Food Funct."},{"key":"B129","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1007\/s00417-004-0880-4","article-title":"Prevalence and risk factors of diabetic retinopathy in adult and elderly subjects: the Casteldaccia Eye Study","volume":"242","author":"Giuffr\u00e8","year":"2004","journal-title":"Graefe's Arch Clin Exp Ophthalmol."},{"key":"B130","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1007\/s00125-008-1091-z","article-title":"Alcohol consumption and risk of microvascular complications in type 1 diabetes patients: the EURODIAB Prospective Complications Study","volume":"51","author":"Beulens","year":"2008","journal-title":"Diabetologia."},{"key":"B131","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1016\/j.jdiacomp.2015.09.001","article-title":"Moderate consumption of white and fortified wine is associated with reduced odds of diabetic retinopathy","volume":"29","author":"Fenwick","year":"2015","journal-title":"J Diabetes Complic."},{"key":"B132","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7326\/M13-1725","article-title":"Prevention of diabetes with Mediterranean diets: a subgroup analysis of a randomized trial","volume":"160","author":"Salas-Salvad\u00f3","year":"2014","journal-title":"Ann Intern Med."},{"key":"B133","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1167\/iovs.05-0580","article-title":"Effect of curcumin on proliferation of human retinal endothelial cells under in vitro conditions","volume":"47","author":"Premanand","year":"2006","journal-title":"Invest Opthalmol Visual Sci."},{"key":"B134","doi-asserted-by":"publisher","first-page":"17295","DOI":"10.1002\/jcp.28347","article-title":"Curcumin prevents high glucose damage in retinal pigment epithelial cells through ERK1\/2-mediated activation of the Nrf2\/HO-1 pathway","volume":"234","author":"Bucolo","year":"2019","journal-title":"J Cell Physiol."},{"key":"B135","doi-asserted-by":"publisher","first-page":"670","DOI":"10.3389\/fphar.2018.00670","article-title":"Retinal protection and distribution of curcumin in vitro and in vivo","volume":"9","author":"Platania","year":"2018","journal-title":"Front Pharmacol."},{"key":"B136","first-page":"901","article-title":"Curcumin protects retinal pigment epithelial cells against oxidative stress via induction of heme oxygenase-1 expression and reduction of reactive oxygen","volume":"18","author":"Woo","year":"2012","journal-title":"Mol Vis."},{"key":"B137","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2018\/5407482","article-title":"Curcumin modulates dna methyltransferase functions in a cellular model of diabetic retinopathy","volume":"2018","author":"Maugeri","year":"2018","journal-title":"Oxid Med Cell Longev."},{"key":"B138","doi-asserted-by":"publisher","first-page":"517","DOI":"10.2337\/diabetes.54.2.517","article-title":"Paradoxical effects of green tea (Camellia sinensis) and antioxidant vitamins in diabetic rats improved retinopathy and renal mitochondrial defects but deterioration of collagen matrix glycoxidation and cross-linking","volume":"54","author":"Mustata","year":"2005","journal-title":"Diabetes."},{"key":"B139","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1167\/iovs.12-10647","article-title":"Green tea is neuroprotective in diabetic retinopathy","volume":"54","author":"Silva","year":"2013","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"B140","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1159\/000330051","article-title":"Green tea prevents hyperglycemia-induced retinal oxidative stress and inflammation in streptozotocin-induced diabetic rats","volume":"47","author":"Kumar","year":"2012","journal-title":"Ophthalmic Res."},{"key":"B141","doi-asserted-by":"publisher","first-page":"3710","DOI":"10.1021\/jf048052l","article-title":"Black and green teas equally inhibit diabetic cataracts in a streptozotocin-induced rat model of diabetes","volume":"53","author":"Vinson","year":"2005","journal-title":"J Agric Food Chem."},{"key":"B142","doi-asserted-by":"publisher","first-page":"111","DOI":"10.4172\/2155-6156.1000111","article-title":"Antioxidants in the prevention and treatment of diabetic retinopathy a review","volume":"1","author":"Silva S","year":"2010","journal-title":"J Diabet Metabol"},{"key":"B143","doi-asserted-by":"publisher","first-page":"128","DOI":"10.3389\/fcell.2019.00128","article-title":"Reprogramming the epigenome with vitamin C","volume":"7","author":"Lee Chong","year":"2019","journal-title":"Front Cell Dev Biol."},{"key":"B144","doi-asserted-by":"publisher","first-page":"2068","DOI":"10.1089\/ars.2013.5205","article-title":"Role of vitamin C in the function of the vascular endothelium","volume":"19","author":"May","year":"2013","journal-title":"Antioxid Redox Signal."},{"key":"B145","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.1002\/jcp.22532","article-title":"Modulation of oxidative stress responses in the human retinal pigment epithelium following treatment with vitamin C","volume":"226","author":"Yin","year":"2011","journal-title":"Wiley Online Library."},{"key":"B146","doi-asserted-by":"publisher","first-page":"9307","DOI":"10.1074\/jbc.M600418200","article-title":"Regulation of intracellular glucose and polyol pathway by thiamine and benfotiamine in vascular cells cultured in high glucose","volume":"281","author":"Berrone","year":"2006","journal-title":"J Biol Chem."},{"key":"B147","doi-asserted-by":"publisher","first-page":"2404","DOI":"10.2337\/diabetes.53.9.2404","article-title":"Studies of rat and human retinas predict a role for the polyol pathway in human diabetic retinopathy","volume":"53","author":"Dagher","year":"","journal-title":"Am Diabetes Assoc."},{"key":"B148","doi-asserted-by":"publisher","first-page":"288","DOI":"10.4239\/wjd.v5.i3.288","article-title":"Evidence for altered thiamine metabolism in diabetes: is there a potential to oppose gluco-and lipotoxicity by rational supplementation?","volume":"5","author":"P\u00e1cal","year":"","journal-title":"World J Diabetes"},{"key":"B149","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1006\/bbrc.1996.0366","article-title":"Thiamine pyrophosphate and pyridoxamine inhibit the formation of antigenic advanced glycation end-products: comparison with aminoguanidine 1","volume":"220","author":"Booth","year":"1996","journal-title":"Biochem Biophys Res Commun."},{"key":"B150","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40662-020-00199-y","article-title":"Nutritional and medical food therapies for diabetic retinopathy","volume":"7","author":"Shi","year":"2020","journal-title":"Eye Vis."},{"key":"B151","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1186\/s13000-014-0167-y","article-title":"Relationship between homocysteine level and diabetic retinopathy: a systematic review and meta-analysis","volume":"9","author":"Xu","year":"2014","journal-title":"Diagn Pathol."},{"key":"B152","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.preteyeres.2006.05.003","article-title":"M\u00fcller cells in the healthy and diseased retina","volume":"25","author":"Bringmann","year":"2006","journal-title":"Prog Retin Eye Res."},{"key":"B153","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.tiv.2017.07.009","article-title":"The vitamin B6 paradox: Supplementation with high concentrations of pyridoxine leads to decreased vitamin B6 function","volume":"44","author":"Vrolijk","year":"2017","journal-title":"Toxicol in Vitro."},{"key":"B154","doi-asserted-by":"publisher","first-page":"1759091419865788","DOI":"10.1177\/1759091419865788","article-title":"Blood flow deficits and cerebrovascular changes in a dietary model of hyperhomocysteinemia","volume":"11","author":"Braun","year":"2019","journal-title":"ASN Neuro."},{"key":"B155","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.biochi.2016.08.009","article-title":"Effect of vitamin B12 and omega-3 fatty acid supplementation on brain neurotrophins and cognition in rats: a multigeneration study","volume":"9","author":"Rathod","year":"2016","journal-title":"Biochimie."},{"key":"B156","unstructured":"2020"},{"key":"B157","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1007\/978-1-4614-5441-0_10","article-title":"Retinopathy in diabetes","volume":"771","author":"Tarr","year":"2013","journal-title":"Adv Exp Med Biol."},{"key":"B158","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.3389\/fendo.2020.621938","article-title":"The role of lipoxidation in the pathogenesis of diabetic retinopathy","volume":"11","author":"Augustine","year":"2021","journal-title":"Front Endocrinol."},{"key":"B159","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1177\/0148607107031005430","article-title":"Advanced glycation and lipoxidation end products\u2013amplifiers of inflammation: the role of food","volume":"31","author":"Bengmark","year":"2007","journal-title":"J Parenteral Enteral Nutr."},{"key":"B160","doi-asserted-by":"publisher","first-page":"3636","DOI":"10.2174\/0929867321666140706141806","article-title":"Physiological effect and therapeutic application of alpha lipoic acid","volume":"21","author":"Park","year":"2014","journal-title":"Curr Med Chem."},{"key":"B161","doi-asserted-by":"publisher","first-page":"4302","DOI":"10.1167\/iovs.04-1098","volume":"46","author":"Voloboueva","year":"2005","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"B162","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1056\/NEJM199309303291401","article-title":"The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus","volume":"329","year":"1993","journal-title":"N Engl J Med."},{"key":"B163","unstructured":"Retinopatia diabetica ed edema maculare\n            Lineeguida per la pratica clinica : gestione delle complicanze oculari del diabete\n          Rodr"},{"key":"B164","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.2337\/db18-0158","article-title":"Restructuring of the Gut microbiome by intermittent fasting prevents retinopathy and prolongs survival in db\/db mice","volume":"67","author":"Beli","year":"2018","journal-title":"Diabetes."},{"key":"B165","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.2337\/dbi18-0022","article-title":"Intermittent fasting and prevention of diabetic retinopathy: where do we go from here?","volume":"67","author":"Haluz\u00edk","year":"2018","journal-title":"Diabetes."},{"key":"B166","doi-asserted-by":"publisher","first-page":"939","DOI":"10.3389\/fendo.2019.00939","article-title":"Combination of oligofructose and metformin alters the gut microbiota and improves metabolic profiles, contributing to the potentiated therapeutic effects on diet-induced obese animals","volume":"10","author":"Li","year":"2020","journal-title":"Front Endocrinol."},{"key":"B167","doi-asserted-by":"publisher","first-page":"3719","DOI":"10.3390\/nu12123719","article-title":"Role of gut microbiota on onset and progression of microvascular complications of type 2 diabetes (T2DM)","volume":"12","author":"Maria Tanase","year":"2020","journal-title":"Nutrients"},{"key":"B168","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1111\/ceo.12306","article-title":"Physical inactivity as a risk factor for diabetic retinopathy? A review","volume":"42","author":"Dirani","year":"2014","journal-title":"Clin Exp Ophthalmol."},{"key":"B169","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1007\/s00592-019-01319-4","article-title":"Physical activity and risk of diabetic retinopathy: a systematic review and meta-analysis","volume":"56","author":"Ren","year":"2019","journal-title":"Acta Diabetol."},{"key":"B170","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1007\/s00592-017-1037-3","article-title":"Physical activity and change in fasting glucose and HbA1c: a quantitative meta-analysis of randomized trials","volume":"54","author":"Boniol","year":"2017","journal-title":"Acta Diabetol."},{"key":"B171","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1113\/EP085207","article-title":"Acute bout of resistance exercise increases vitamin D receptor protein expression in rat skeletal muscle","volume":"100","author":"Makanae","year":"2015","journal-title":"Exp Physiol."},{"key":"B172","doi-asserted-by":"publisher","first-page":"7239639","DOI":"10.1155\/2016\/7239639","article-title":"Exercise modulates oxidative stress and inflammation in aging and cardiovascular diseases","volume":"2016","author":"Sallam","year":"2016","journal-title":"Oxid Med Cell Longev."},{"key":"B173","doi-asserted-by":"publisher","first-page":"21008","DOI":"10.3390\/ijms160921008","article-title":"Treadmill exercise attenuates retinal oxidative stress in naturally-aged mice: an immunohistochemical study","volume":"16","author":"Kim","year":"2015","journal-title":"Int J Mol Sci."},{"key":"B174","doi-asserted-by":"publisher","first-page":"241","DOI":"10.2174\/1389557516666151120114605","article-title":"The role oxidative stress in the pathogenesis of eye diseases: currnt status and a dual role of physical activity","volume":"16","author":"Kruk","year":"2016","journal-title":"Mini Rev Med Chem."},{"key":"B175","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1111\/ejn.13909","article-title":"TrkB signalling pathway mediates the protective effects of exercise in the diabetic rat retina","volume":"47","author":"Allen","year":"2018","journal-title":"Eur J Neurosci."},{"key":"B176","first-page":"5434","article-title":"Exercise inhibits progression of diabetic retinopathy by reducing inflammatory, oxidative stress, and ER stress gene expression in the retina of db\/db mice","volume":"57","author":"Cui","year":"2016","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.2337\/9781580404853","article-title":"Exercise and diabetes: a clinician's guide to prescribing physical activity","author":"Colberg","year":"2013","journal-title":"Am Diabetes Assoc."},{"key":"B178","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1177\/014572179001600312","article-title":"Exercise options for persons with diabetic complications","volume":"16","author":"Graham","year":"1990","journal-title":"Diabetes Educ."},{"key":"B179","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/S0889-8529(05)70220-6","article-title":"Diet and exercise in type 2 diabetes mellitus","volume":"30","author":"Hamdy","year":"2001","journal-title":"Endocrinol Metab Clin North Am."},{"key":"B180","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1152\/jappl.1999.87.3.1075","article-title":"Hypertrophy of skeletal muscle in diabetic rats in response to chronic resistance exercise","volume":"87","author":"Farrell","year":"1999","journal-title":"J Appl Physiol."},{"key":"B181","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1097\/IIO.0b013e31819fd5d7","article-title":"The role of genetics in susceptibility to diabetic retinopathy","volume":"49","author":"Liew","year":"2009","journal-title":"Int Ophthalmol Clin."},{"key":"B182","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/S0004-9514(09)70003-0","article-title":"Progressive resistance exercise improves glycaemic control in people with type 2 diabetes mellitus: a systematic review","volume":"55","author":"Irvine","year":"2009","journal-title":"Austral J Physiother."},{"key":"B183","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.ajo.2014.04.016","article-title":"The relationship of major American dietary patterns to age-related macular degeneration","volume":"158","author":"Chiu","year":"2014","journal-title":"Am J Ophthalmol."},{"key":"B184","doi-asserted-by":"publisher","first-page":"10","DOI":"10.20944\/preprints201810.0369.v1","article-title":"The role of diet, micronutrients and the gut microbiota in age-related macular degeneration: new perspectives from the gut\u2212retina axis","author":"Rinninella","year":"2018","journal-title":"Nutrients."},{"key":"B185","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1055\/s-0029-1245527","article-title":"Mikron\u00e4hrstoffe und ihre Bedeutung f\u00fcr das Auge Wirkungsweise von Lutein\/Zeaxanthin und Omega-3-Fetts\u00e4uren","volume":"228","author":"Schweigert","year":"2011","journal-title":"Klin Monbl Augenheilkd."},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.005744","article-title":"Zinc: an essential but elusive nutrient","author":"King","year":"2011","journal-title":"Am J Clin Nutr."},{"key":"B187","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.ajo.2008.08.014","article-title":"Reduced zinc and copper in the retinal pigment epithelium and choroid in age-related macular degeneration","volume":"147","author":"Erie","year":"2009","journal-title":"Am J Ophthalmol."},{"key":"B188","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.ajo.2017.05.016","article-title":"Physical activity and age-related macular degeneration: a systematic literature review and meta-analysis","volume":"180","author":"McGuinness","year":"2017","journal-title":"Am J Ophthalmol."},{"key":"B189","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1076\/ceyr.16.9.857.5039","article-title":"Vitamin C in human and guinea pig aqueous, lens and plasma in relation to intake","volume":"16","author":"Taylor","year":"1997","journal-title":"Curr Eye Res."},{"key":"B190","first-page":"392","article-title":"Age differences in corneal hydration control","volume":"30","author":"Polse","year":"1989","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"B191","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1159\/000050837","article-title":"Eventual error caused by dehydration with pachometry","volume":"215","author":"Sabetti","year":"2001","journal-title":"Ophthalmologica."},{"key":"B192","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1167\/iovs.07-1151","article-title":"Free and bound water in normal and cataractous human lenses","volume":"49","author":"Heys","year":"2008","journal-title":"Invest Ophthalmol Vis Sci."},{"key":"B193","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1002\/dmrr.1075","article-title":"Diabetic cataracts: mechanisms and management","volume":"26","author":"Obrosova","year":"2010","journal-title":"Diabetes Metab Res Rev."},{"key":"B194","doi-asserted-by":"publisher","first-page":"467130","DOI":"10.1155\/2012\/467130","article-title":"Antioxidant capacity of lenses with age-related cataract","volume":"2012","author":"Kisic","year":"2012","journal-title":"Oxid Med Cell Longev."},{"key":"B195","doi-asserted-by":"publisher","first-page":"366","DOI":"10.3389\/fphys.2013.00366","article-title":"Lipid peroxidation: pathophysiological and pharmacological implications in the eye","volume":"4","author":"Njie-Mbye","year":"2013","journal-title":"Front Physiol."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2023.1168560\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T12:34:08Z","timestamp":1685536448000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2023.1168560\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,30]]},"references-count":195,"alternative-id":["10.3389\/fmed.2023.1168560"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2023.1168560","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,30]]},"article-number":"1168560"}}