{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:02:17Z","timestamp":1753891337847,"version":"3.41.2"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T00:00:00Z","timestamp":1683590400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome is a rare musculoskeletal disease characterized by dermatological and osteoarticular lesions. However, SAPHO syndrome is difficult to be diagnosed due to the rarity and complexity. Additionally, there is no standard treatment for SAPHO syndrome based on limited experience. Percutaneous vertebroplasty (PVP) has rarely been reported to treat SAPHO syndrome. We reported a 52-year-old female patient who had a sex-month history of back pain. Palmoplantar pustulosis appeared on the hands and feet. Vertebral destruction was observed on computed tomography (CT) scanning. Laboratory examination showed that erythrocyte sedimentation rate (ESR) and C-reactive protein were elevated. Finally, the patient was diagnosed with SAPHO syndrome and treated with PVP. After the surgery, the back pain was significantly relieved. In this study, we mainly discussed the treatment methods of SAPHO syndrome, and provided a potential treatment for SAPHO syndrome, especially with vertebral destruction, kyphosis, and even pathological fractures.<\/jats:p>","DOI":"10.3389\/fmed.2023.1175787","type":"journal-article","created":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T05:01:47Z","timestamp":1683608507000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Percutaneous vertebroplasty for SAPHO syndrome with vertebral destruction: a case report and literature review"],"prefix":"10.3389","volume":"10","author":[{"given":"Yuanpei","family":"Cheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junhan","family":"Mu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jialin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,5,9]]},"reference":[{"key":"B1","first-page":"187","article-title":"Acne-pustulosis-hyperostosis-osteitis syndrome. 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A new syndrome among the spondyloarthropathies?.","volume":"6","author":"Benhamou","year":"1988","journal-title":"Clin Exp Rheumatol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/j.semarthrit.2013.10.010","article-title":"Disease burden, disease manifestations and current treatment regimen of the SAPHO syndrome in Germany: results from a nationwide patient survey.","volume":"43","author":"Witt","year":"2014","journal-title":"Semin Arthritis Rheum."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-019-2410-x","article-title":"SAPHO syndrome with pathological fractures of vertebral bodies: a case report.","volume":"20","author":"Li","year":"2019","journal-title":"BMC Musculoskelet Disord."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2018-225929","article-title":"SAPHO syndrome with enthesopathy.","volume":"12","author":"Su","year":"2019","journal-title":"BMJ Case Rep."},{"key":"B13","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1055\/s-2007-1024251","article-title":"Vertebral destruction with sever pain in the SAPHO syndrome.","volume":"124","author":"Hagemann","year":"1999","journal-title":"Dtsch Med Wochenschr."},{"key":"B14","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1111\/ijd.13740","article-title":"SAPHO syndrome associated with hidradenitis suppurativa and pyoderma gangrenosum successfully treated with adalimumab and methotrexate: a case report and review of the literature.","volume":"57","author":"Vekic","year":"2018","journal-title":"Int J Dermatol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"184","DOI":"10.24953\/turkjped.2017.02.011","article-title":"Successful treatment of a childhood synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome with subcutaneous methotrexate: a case report.","volume":"59","author":"Akcaboy","year":"2017","journal-title":"Turk J Pediatr."},{"key":"B16","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1111\/jdv.15849","article-title":"Successful treatment of co-existent SAPHO syndrome and hidradenitis suppurativa with adalimumab and methotrexate.","author":"Genovese","year":"2019","journal-title":"J Eur Acad Dermatol Venereol."},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000016045","article-title":"Long-term remarkable remission of SAPHO syndrome in response to short-term systemic corticosteroids treatment in an immunoglobulin E elevated patient: a case report.","volume":"98","author":"Wang","year":"2019","journal-title":"Medicine."},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000005724","article-title":"The coexistence of SAPHO syndrome and rheumatoid arthritis: a case report.","volume":"96","author":"Xu","year":"2017","journal-title":"Medicine."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.3109\/14397595.2013.874744","article-title":"Severe inflammation associated with synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome was markedly ameliorated by single use of minocycline.","volume":"24","author":"Takizawa","year":"2014","journal-title":"Mod Rheumatol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"2547","DOI":"10.2147\/ccid.S384346","article-title":"SAPHO Syndrome with palmoplantar pustulosis as the first manifestation successfully treated with adalimumab.","volume":"15","author":"Yang","year":"2022","journal-title":"Clin Cosmet Investig Dermatol."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000030065","article-title":"Exceptional response of skin symptoms to secukinumab treatment in a patient with SAPHO syndrome: case report and literature review.","volume":"101","author":"Ji","year":"2022","journal-title":"Medicine."},{"key":"B22","doi-asserted-by":"publisher","first-page":"55","DOI":"10.2165\/11593250-000000000-00000","article-title":"Long-term treatment of severe SAPHO syndrome with adalimumab: case report and a review of the literature.","volume":"13","author":"Garcovich","year":"2012","journal-title":"Am J Clin Dermatol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"267","DOI":"10.22603\/ssrr.2018-0035","article-title":"Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome with destructive spondylitis: a case report.","volume":"3","author":"Nakamae","year":"2019","journal-title":"Spine Surg Relat Res."},{"key":"B24","article-title":"Successful treatment of SAPHO syndrome with leflunomide. 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