{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T07:44:20Z","timestamp":1769154260356,"version":"3.49.0"},"reference-count":17,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T00:00:00Z","timestamp":1688342400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the dose\u2013response of nitroglycerin in preventing pituitrin-induced hypertension in patients undergoing laparoscopic myomectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Hundred patients scheduled for elective laparoscopic myomectomy were randomly allocated into one of five groups (<jats:italic>n<\/jats:italic>\u2009=\u200920) to receive intravenous bolus of prophylactic nitroglycerin at 0, 50, 75, 100, and 125\u2009\u03bcg one minute following administration of 3\u2009IU of pituitrin into the myometrium. The patients were monitored for pituitrin-induced hypertension with the primary outcome to determine the effective dose of prophylactic nitroglycerin, defined as complete prevention of pituitrin-induced hypertension during the study period. Probit analysis was used to calculate the median effective dose (ED<jats:sub>50<\/jats:sub>) and 95% effective dose (ED<jats:sub>95<\/jats:sub>) of prophylactic nitroglycerin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hypertension occurred in 19\/20, 10\/20, 8\/20, 2\/20, and 1\/20 in patients who received 0, 50, 75, 100, and 125 ug of prophylactic nitroglycerin, respectively. The calculated ED<jats:sub>50<\/jats:sub> and ED<jats:sub>95<\/jats:sub> of nitroglycerin for preventing hypertension were 54\u2009\u03bcg (95%CI: 35~66\u2009\u03bcg) and 136\u2009\u03bcg (95%CI: 105~289\u2009\u03bcg).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A prophylactic bolus of nitroglycerin administered immediately following injection of pituitrin into the myometrium during laparoscopic myomectomy effectively prevented pituitrin-induced hypertension, with the ED<jats:sub>50<\/jats:sub> and ED<jats:sub>95<\/jats:sub> of 54\u2009\u03bcg and 136\u2009\u03bcg, respectively. This information would be useful for clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical trial registration<\/jats:title><jats:p><jats:ext-link>www.chictr.org.cn<\/jats:ext-link>, Identifier ChiCTR2200062282.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2023.1186041","type":"journal-article","created":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T07:52:53Z","timestamp":1688370773000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Dose\u2013response study of prophylactic nitroglycerin for prevention of pituitrin-induced hypertension during laparoscopic myomectomy: a prospective, randomized study"],"prefix":"10.3389","volume":"10","author":[{"given":"Jin","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,7,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1111\/1471-0528.14179","article-title":"Dilute versus concentrated vasopressin administration during laparoscopic myomectomy: a randomised controlled trial","volume":"124","author":"Cohen","year":"2017","journal-title":"BJOG"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.ejogrb.2015.10.003","article-title":"Use of vasopressin vs epinephrine to reduce haemorrhage during myomectomy: a randomized controlled trial","volume":"195","author":"Song","year":"2015","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"3125","DOI":"10.3892\/mmr.2017.6963","article-title":"Protective effects of Shexiang Tongxin dropping pill on pituitrin-induced acute myocardial ischemia in rats","volume":"16","author":"Lin","year":"2017","journal-title":"Mol Med Rep"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"2073","DOI":"10.1016\/j.jmig.2021.06.008","article-title":"Optimal dose of Pituitrin in laparoscopic uterine myomectomy: a double-blinded, randomized controlled trial","volume":"28","author":"Guo","year":"2021","journal-title":"J Minim Invasive Gynecol"},{"key":"ref5","first-page":"363","article-title":"Vasopressin as a hemostatic in gynecologic surgery; 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