{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:22:57Z","timestamp":1792009377556,"version":"4.4.0"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T00:00:00Z","timestamp":1699315200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Background\/aims<\/jats:title><jats:p>Colonic diverticular bleeding (CDB) is a common cause of acute lower gastrointestinal bleeding. Patients with CDB are at increased risk for recurrence. Here, we aimed to evaluate the clinical course of patients with CDB and identify risk factors for recurrent CDB (rCDB).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included patients who were hospitalized at a single tertiary center for management of CDB between January 2005 and March 2020. A Cox proportional hazards regression analysis was performed to evaluate the risk factors of patients with rCDB as follows: model 1 adjusted by age, Charlson comorbidity index (CCI), and presence of bilateral colon diverticula; model 2 adjusted by age, CCI, and presence of left side colon diverticula; model 3 adjusted by age, CCI, and presence of sigmoid colon diverticula.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 219 patients (mean age, 68.0\u2009years; 55 females), 56 and 163 had definite and presumptive CDB, respectively. During the median period of 506\u2009days, 62 patients (28.3%) experienced rCDB. CCI score\u2009\u2265\u20094 was independently associated with rCDB in models 1, 2 and 3 (all <jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05). Age\u2009\u2265\u200975\u2009years was independently associated with rCDB in models 1 and 2 (both <jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05). The presence of bilateral colon and sigmoid colon diverticula were independently associated with rCDB in models 1 and 3, respectively (both <jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>rCDB frequently occurred at any time in patients with previous CDB. High CCI scores and distribution of colon diverticula were associated with rCDB. Clinicians should consider a possible rCDB for a patient considering age, comorbidity, and distribution of colon diverticula.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2023.1195051","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T08:03:40Z","timestamp":1699344220000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Risk factors for patients hospitalized with recurrent colon diverticular bleeding: a single center experience"],"prefix":"10.3389","volume":"10","author":[{"given":"Hye-Su","family":"You","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seo-Yeon","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seon-Young","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Hwan","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Soo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Kyu","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,11,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1038\/ajg.2009.164","article-title":"Time trends and impact of upper and lower gastrointestinal bleeding and perforation in clinical practice","volume":"104","author":"Lanas","year":"2009","journal-title":"Am J Gastroenterol"},{"key":"ref2","first-page":"419","article-title":"Epidemiology and outcome of patients hospitalized with acute lower gastrointestinal hemorrhage: a population-based study","volume":"92","author":"Longstreth","year":"1997","journal-title":"Am J Gastroenterol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"440","DOI":"10.4292\/wjgpt.v7.i3.440","article-title":"Increase in colonic diverticular hemorrhage and confounding factors","volume":"7","author":"Kinjo","year":"2016","journal-title":"World J Gastrointest Pharmacol Ther"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1111\/j.1463-1318.2011.02611.x","article-title":"Recurrence of colonic diverticular bleeding and associated risk factors","volume":"14","author":"Niikura","year":"2012","journal-title":"Color Dis"},{"key":"ref5","first-page":"20","article-title":"Risk factors associated with recurrent hemorrhage after the initial improvement of colonic diverticular bleeding","volume":"76","author":"Nishikawa","year":"2013","journal-title":"Acta Gastroenterol Belg"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"e8090","DOI":"10.1097\/MD.0000000000008090","article-title":"Analysis of risk factors for colonic diverticular bleeding and recurrence","volume":"96","author":"Taki","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1111\/j.1365-2036.2010.04362.x","article-title":"Natural history of acute colonic diverticular bleeding: a prospective study in 133 consecutive patients","volume":"32","author":"Poncet","year":"2010","journal-title":"Aliment Pharmacol Ther"},{"key":"ref8","volume-title":"International statistical classification of diseases and related health problems: Tabular list","year":"2004"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"573","DOI":"10.5124\/jkma.2018.61.9.573","article-title":"Cause-of-death statistics in 2016 in the Republic of Korea","volume":"61","author":"Shin","year":"2018","journal-title":"J Korean Med Assoc"},{"key":"ref10","first-page":"255","article-title":"Diverticular disease with acute hemorrhage","volume-title":"Principles of Surgery","author":"Goldberg","year":"1989"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1097\/00000658-199411000-00008","article-title":"Bleeding colonic diverticula. 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