{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:04:55Z","timestamp":1753891495340,"version":"3.41.2"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T00:00:00Z","timestamp":1691107200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>The Drug Rash with Eosinophilia and Systemic Symptoms (DRESS) syndrome can be potentially life-threatening. The diagnosis is sometimes difficult since the clinical manifestations may be incomplete or non-specific. Insulinoma is a rare functioning neuroendocrine tumor (NET) of the pancreas. Medical therapy may be needed when surgery is contraindicated, delayed or refused. Diazoxide is widely used to control hypoglycemia in patients with insulinoma. We report a clinical case of an insulinoma in a 85-year-old patient treated with diazoxide with a fatal outcome due to a delayed diagnosis of a DRESS syndrome. This is the first case of DRESS syndrome reported after using diazoxide for insulinoma treatment in our knowledge.<\/jats:p>","DOI":"10.3389\/fmed.2023.1196041","type":"journal-article","created":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T08:33:14Z","timestamp":1691137994000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["A posteriori diagnosis of DRESS syndrome induced by diazoxide in a patient with an insulinoma: a case report and review of the literature"],"prefix":"10.3389","volume":"10","author":[{"given":"Najoua","family":"Lassoued","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wafa","family":"Alaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sondos","family":"Arfa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mouna","family":"Korbi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ines","family":"Lassoued","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soumaya Ben","family":"Amor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma","family":"Zaouali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zayneb","family":"Farhat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jihen","family":"Chelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Habib Sfar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,8,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.amjmed.2011.01.017","article-title":"The DRESS syndrome: a literature review","volume":"124","author":"Cacoub","year":"2011","journal-title":"Am J Med"},{"key":"B2","doi-asserted-by":"publisher","first-page":"30","DOI":"10.4103\/ijd.IJD_582_17","article-title":"Drug reaction with eosinophilia and systemic symptoms: an update and review of recent literature","volume":"63","author":"De","year":"2018","journal-title":"Indian J Dermatol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1097\/MD.0b013e3181a4d1a1","article-title":"Drug-induced hypersensitivity syndrome: clinical and biologic disease patterns in 24 patients","volume":"88","author":"Ben M'rad","year":"2009","journal-title":"Medicine (Baltimore)"},{"key":"B4","doi-asserted-by":"publisher","first-page":"229","DOI":"10.2217\/fon.09.165","article-title":"Insulinoma: pathophysiology, localization and management","volume":"6","author":"Shin","year":"2010","journal-title":"Future Oncol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"20","DOI":"10.21037\/gs.2017.10.08","article-title":"Management of functional neuroendocrine tumors of the pancreas","volume":"7","author":"\u00d6berg","year":"2018","journal-title":"Gland. Surg"},{"key":"B6","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1159\/000443171","article-title":"ENETS consensus guidelines update for the management of patients with functional pancreatic neuroendocrine tumors and non-functional pancreatic neuroendocrine tumors","volume":"103","author":"Falconi","year":"2016","journal-title":"Neuroendocrinology."},{"key":"B7","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.lpm.2013.08.007","article-title":"Recommandations pour la prise en charge de l'insulinome malin","volume":"43","author":"Baudin","year":"2014","journal-title":"Presse Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/ncpendmet1046","article-title":"Advances in the diagnosis and management of hyperinsulinemic hypoglycemia","volume":"5","author":"Kapoor","year":"2009","journal-title":"Nat Clin Pract Endocrinol Metab"},{"key":"B9","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1507\/endocrj.EJ15-0428","article-title":"Safety and tolerability of diazoxide in Japanese patients with hyperinsulinemic hypoglycemia","volume":"63","author":"Komatsu","year":"2016","journal-title":"Endocr J."},{"key":"B10","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1530\/EDM-20-0132","article-title":"Successful medical management of insulinoma with diazoxide for 27 years","volume":"20","author":"Warren","year":"2020","journal-title":"Endocrinol Diabetes Metab Case Rep."},{"key":"B11","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1007\/BF01655532","article-title":"Diazoxide in the management of patients with insulinoma","volume":"10","author":"Goode","year":"1986","journal-title":"World J Surg"},{"key":"B12","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1136\/pgmj.73.864.640","article-title":"Diazoxide treatment for insulinoma: a national UK survey","volume":"73","author":"Gill","year":"1997","journal-title":"Postgrad Med J."},{"key":"B13","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1111\/j.1749-6632.1968.tb19045.x","article-title":"Diazoxide and the treatment of hypoglycemia: an historical review","volume":"150","author":"Black","year":"1968","journal-title":"Ann N Y Acad Sci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/0026-0495(64)90133-7","article-title":"Drug therapy in leucine-sensitive hypoglycemia","volume":"13","author":"Drash","year":"1964","journal-title":"Metabolism."},{"key":"B15","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1159\/000497458","article-title":"Rate of serious adverse events associated with diazoxide treatment of patients with hyperinsulinism","volume":"91","author":"Thornton","year":"2019","journal-title":"Horm Res Paediatr"},{"key":"B16","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1111\/j.1749-6632.1968.tb19059.x","article-title":"The therapeutic application of diazoxide in pediatric hypoglycemic states","volume":"150","author":"Drash","year":"1968","journal-title":"Ann NY Acad Sci"},{"key":"B17","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1186\/s13023-015-0367-x","article-title":"Long-term medical treatment in congenital hyperinsulinism: a descriptive analysis in a large cohort of patients from different clinical centers","volume":"10","author":"Welters","year":"2015","journal-title":"Orphanet J Rare Dis"},{"key":"B18","doi-asserted-by":"publisher","first-page":"40","DOI":"10.4103\/idoj.idoj_196_21","article-title":"RegiSCAR DRESS (drug reaction with eosinophilia and systemic symptoms) validation scoring system and japanese consensus group criteria for atypical drug-induced hypersensitivity syndrome (DiHS): a comparative analysis","volume":"13","author":"Sasidharanpillai","year":"2022","journal-title":"Indian Dermatol Online J"},{"key":"B19","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1507\/endocrj.EJ18-0353","article-title":"Clinical outcomes of 20 Japanese patients with insulinoma treated with diazoxide","volume":"66","author":"Niitsu","year":"2019","journal-title":"Endocr J"},{"key":"B20","first-page":"326","article-title":"Hypertrichosis lanuginosa and a lichenoid eruption due to diazoxide therapy","volume":"66","author":"Menter","year":"1973","journal-title":"Proc R Soc Med."},{"key":"B21","first-page":"688","article-title":"Drug reaction with eosinophilia and systemic symptoms","volume":"6","author":"Tehrany","year":"2016","journal-title":"Rev Med Suisse."},{"key":"B22","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/j.annder.2010.04.024","article-title":"Management of drug reaction with eosinophilia and systemic symptoms (DRESS)","volume":"137","author":"Descamps","year":"2010","journal-title":"Ann Dermatol Venereol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"391","DOI":"10.2165\/00002018-200932050-00003","article-title":"Patch testing for the diagnosis of anticonvulsant hypersensitivity syndrome: a systematic review","volume":"32","author":"Elzagallaai","year":"2009","journal-title":"Drug Saf."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1111\/j.1398-9995.2007.01553.x","article-title":"Utility of the lymphocyte transformation test in the diagnosis of drug sensitivity: dependence on its timing and the type of drug eruption","volume":"62","author":"Kano","year":"2007","journal-title":"Allergy"},{"key":"B25","doi-asserted-by":"publisher","first-page":"229","DOI":"10.18176\/jiaci.0480","article-title":"Spanish guidelines for diagnosis, management, treatment, and prevention of DRESS syndrome","volume":"30","author":"Caba\u00f1as","year":"2020","journal-title":"J Investig Allergol Clin Immunol."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2023.1196041\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,4]],"date-time":"2023-08-04T08:33:27Z","timestamp":1691138007000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2023.1196041\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,4]]},"references-count":25,"alternative-id":["10.3389\/fmed.2023.1196041"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2023.1196041","relation":{},"ISSN":["2296-858X"],"issn-type":[{"type":"electronic","value":"2296-858X"}],"subject":[],"published":{"date-parts":[[2023,8,4]]},"article-number":"1196041"}}