{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T23:02:13Z","timestamp":1769554933266,"version":"3.49.0"},"reference-count":46,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:00:00Z","timestamp":1696896000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Recently, the application of the amniotic membrane (AM) in ophthalmology is gradually expanding from the anterior to the posterior segment of the eye. Its characteristics of anti-inflammation, anti-bacterial, anti-vascularization, immune regulation, anti-fibrosis, pro-epithelialization, and so forth have made it a hot topic in ophthalmic research. AM has been confirmed to repair photoreceptors, restore normal retinal structures, and close the abnormal structures in the optic disc. Currently, the application areas mainly include retinal hole, retinal detachment, optic disc pit, retinal degenerative diseases, and choroidal hole. This article reviews the current literature applying AM transplantation in the treatment of various posterior segment diseases while comparing the clinical outcomes with other techniques.<\/jats:p>","DOI":"10.3389\/fmed.2023.1206577","type":"journal-article","created":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T07:03:58Z","timestamp":1696921438000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Application progress of human amniotic membrane in vitreoretinopathy: a literature review"],"prefix":"10.3389","volume":"10","author":[{"given":"Huawei","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyue","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anhuai","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,10,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.ajog.2006.10.908","article-title":"Natural antimicrobial production by the amnion","volume":"196","author":"Stock","year":"2007","journal-title":"Am J Obstetr Gynecol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1111\/wrr.12188","article-title":"Amniotic membrane: New concepts for an old dressing: amniotic membrane: the new old dressing","volume":"22","author":"Litwiniuk","year":"2014","journal-title":"Wound Repair Regener"},{"key":"B3","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1136\/bjo.85.4.444","article-title":"Suppression of interleukin 1alpha and interleukin 1beta in human limbal epithelial cells cultured on the amniotic membrane stromal matrix","volume":"85","author":"Solomon","year":"2001","journal-title":"Br J Ophthalmol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1002\/(SICI)1097-4652(199906)179:3<325::AID-JCP10>3.0.CO;2-X","article-title":"Suppression of transforming growth factor-beta isoforms, TGF-beta receptor type II, and myofibroblast differentiation in cultured human corneal and limbal fibroblasts by amniotic membrane matrix","volume":"179","author":"Tseng","year":"1999","journal-title":"J Cell Physiol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/S0301-2115(00)00345-6","article-title":"Antibacterial properties of human amnion and chorion in vitro","volume":"94","author":"Kjaergaard","year":"2001","journal-title":"Eur J Obstetr Gynecol Reprod Biol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/0143-4004(91)90010-D","article-title":"Antibacterial properties of human amniotic membranes","volume":"12","author":"Talmi","year":"1991","journal-title":"Placenta"},{"key":"B7","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/295325a0","article-title":"Expression of HLA antigens, \u03b22-microglobulin and enzymes by human amniotic epithelial cells","volume":"295","author":"Adinolfi","year":"1982","journal-title":"Nature"},{"key":"B8","first-page":"1539","article-title":"Immunogenicity of human amniotic membrane in experimental xenotransplantation","volume":"42","author":"Kubo","year":"2001","journal-title":"Investig Ophthalmol Vis Sci"},{"key":"B9","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1097\/00003226-200005000-00018","article-title":"Identification of antiangiogenic and antiinflammatory proteins in human amniotic membrane","volume":"19","author":"Hao","year":"2000","journal-title":"Cornea"},{"key":"B10","doi-asserted-by":"publisher","first-page":"41","DOI":"10.3109\/08820538.2012.730105","article-title":"Clinical outcomes of amniot\u0131c membrane transplantat\u0131on in patients with corneal and conjunctival disorders","volume":"28","author":"Celik","year":"2013","journal-title":"Semin Ophthalmol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"88","DOI":"10.22203\/eCM.v015a07","article-title":"Properties of the amniotic membrane for potential use in tissue engineering","volume":"15","author":"Niknejad","year":"2008","journal-title":"Eur Cells Mater"},{"key":"B12","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1126\/science.7531366","article-title":"Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix","volume":"267","author":"Boudreau","year":"1995","journal-title":"Science"},{"key":"B13","doi-asserted-by":"publisher","first-page":"S95","DOI":"10.1097\/IAE.0000000000002320","article-title":"A human amniotic membrane plug to promote retinal breaks repair and recurrent macular hole closure","volume":"39","author":"Rizzo","year":"2019","journal-title":"Retina"},{"key":"B14","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1177\/1120672119891415","article-title":"Amniotic membrane for retinal detachment due to paravascular retinal breaks over patchy chorioretinal atrophy in pathologic myopia","volume":"30","author":"Caporossi","year":"2020","journal-title":"Eur J Ophthalmol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1177\/1120672120953314","article-title":"Human amniotic membrane patch and platelet-rich plasma to promote retinal hole repair in a recurrent retinal detachment","volume":"31","author":"Di Tizio","year":"2021","journal-title":"Eur J Ophthalmol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s40942-020-00264-7","article-title":"Lyophilized amniotic membrane patch (LAMPatch) as a replacement of tamponades in the treatment of primary rhegmatogenous retinal detachment","volume":"6","author":"Saravia","year":"2020","journal-title":"Int J Retina Vitr"},{"key":"B17","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1097\/00006982-199515010-00010","article-title":"Clinicopathologic correlation of an epiretinal membrane associated with a recurrent macular hole","volume":"15","author":"Fekrat","year":"1995","journal-title":"Retina"},{"key":"B18","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1097\/00006982-199212040-00001","article-title":"Clinicopathologic study of bilateral macular holes treated with pars plana vitrectomy and gas tamponade","volume":"12","author":"Funata","year":"1992","journal-title":"Retina"},{"key":"B19","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/S0161-6420(94)31278-4","article-title":"Clinicopathologic correlation of a macular hole treated by cortical vitreous peeling and gas tamponade","volume":"101","author":"Madreperla","year":"1994","journal-title":"Ophthalmology"},{"key":"B20","first-page":"179","article-title":"Outcome Of recurrent macular hole closure with amniotic membrane plug","volume":"33","author":"Saad","year":"2021","journal-title":"J Ayub Med Coll"},{"key":"B21","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1111\/aos.14109","article-title":"human amniotic membrane plug to repair retinal detachment associated with large macular tear","volume":"97","author":"Caporossi","year":"2019","journal-title":"Acta Ophthalmol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.1007\/s00417-020-04665-0","article-title":"The amniotic membrane for retinal pathologies. Insights on the surgical techniques","volume":"258","author":"Caporossi","year":"2020","journal-title":"Graefe Arch Clin Exp Ophthalmol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1159\/000487337","article-title":"Multiple free internal limiting membrane flap insertion in the treatment of macular hole-associated retinal detachment in high myopia","volume":"240","author":"Chen","year":"2018","journal-title":"Ophthalmologica"},{"key":"B24","doi-asserted-by":"publisher","first-page":"e1031","DOI":"10.1111\/aos.15013","article-title":"Comparative analysis of macular microstructure in eyes treated with human amniotic membrane plug or internal limiting membrane transplant for failed macular hole","volume":"100","author":"Pacini","year":"2022","journal-title":"Acta Ophthalmol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.3109\/02713689609017657","article-title":"Photoreceptor repair in response to RPE transplants in RCS rats: outer segment regeneration","volume":"15","author":"Lin","year":"1996","journal-title":"Curr Eye Res"},{"key":"B26","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1177\/112067219900900310","article-title":"Daf\u00e5rd Kopp E. Long-term outcome of RPE allografts in non-immunosuppressed patients with AMD","volume":"9","author":"Algvere","year":"1999","journal-title":"Eur J Ophthalmol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1034\/j.1600-0420.1999.770301.x","article-title":"Long-term outcome of RPE allografts to the subretinal space of rabbits","volume":"77","author":"Crafoord","year":"1999","journal-title":"Acta Ophthalmol Scand"},{"key":"B28","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1034\/j.1600-0420.2003.00076.x","article-title":"Amniotic membrane as support for human retinal pigment epithelium (RPE) cell growth","volume":"81","author":"Cape\u00e1ns","year":"2003","journal-title":"Acta Ophthalmol Scand"},{"key":"B29","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.neulet.2012.12.055","article-title":"Mesenchymal stem cells from trabecular meshwork become photoreceptor-like cells on amniotic membrane","volume":"541","author":"Nadri","year":"2013","journal-title":"Neurosci Lett"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1634\/stemcells.2004-0357","article-title":"Stem cell characteristics of amniotic epithelial cells","volume":"23","author":"Miki","year":"2005","journal-title":"Stem Cells"},{"key":"B31","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s12015-006-0020-0","article-title":"Amnion-derived pluripotent\/multipotent stem cells","volume":"2","author":"Miki","year":"2006","journal-title":"Stem Cell Rev"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.1177\/0963689718796196","article-title":"Subretinal transplantation of human amniotic epithelial cells in the treatment of autoimmune uveitis in rats","volume":"27","author":"Li","year":"2018","journal-title":"Cell Transplant"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1038\/aps.2018.22","article-title":"Biological characterization of human amniotic epithelial cells in a serum-free system and their safety evaluation","volume":"39","author":"Yang","year":"2018","journal-title":"Acta Pharmacol Sin"},{"key":"B34","doi-asserted-by":"publisher","first-page":"8722","DOI":"10.3390\/ijms23158722","article-title":"Repair of retinal degeneration by human amniotic epithelial stem cell\u2014derived photoreceptor\u2014like cells","volume":"23","author":"Li","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B35","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1016\/j.oret.2020.04.017","article-title":"Human amniotic membrane plug to restore age-related macular degeneration photoreceptor damage","volume":"4","author":"Rizzo","year":"2020","journal-title":"Ophthalmol Retina"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1998","DOI":"10.3390\/life12121998","article-title":"Subretinal transplant of human amniotic membrane in advanced age-related macular degeneration","volume":"12","author":"Caporossi","year":"2022","journal-title":"Life"},{"key":"B37","doi-asserted-by":"publisher","first-page":"e1143","DOI":"10.1111\/aos.15045","article-title":"Management of submacular massive haemorrhage in age-related macular degeneration: comparison between subretinal transplant of human amniotic membrane and subretinal injection of tissue plasminogen activator","volume":"100","author":"Caporossi","year":"2022","journal-title":"Acta Ophthalmol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"247","DOI":"10.22608\/APO.2018473","article-title":"Optic disc pit maculopathy: a review Asia Pac J Ophthalmol","volume":"8","author":"Kalogeropoulos","year":"2019"},{"key":"B39","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1097\/IAE.0000000000002753","article-title":"Management of optic disk pit-associated macular detachment with human amniotic membrane patch","volume":"43","author":"Rizzo","year":"2023","journal-title":"Retina"},{"key":"B40","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.ajo.2022.02.014","article-title":"Optic disk pit maculopathy treatment using a human amniotic membrane patch: one-year results","volume":"240","author":"Caporossi","year":"2022","journal-title":"Am J Ophthalmol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"357","DOI":"10.4103\/0974-9233.120008","article-title":"Inverted autologous internal limiting membrane for management of optic disc pit with macular detachment","volume":"20","author":"Mohammed","year":"2013","journal-title":"Middle East Afr J Ophthalmol"},{"key":"B42","article-title":"Clinical Neuro-ophthalmology","author":"Miller","year":"1982"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1038\/sj.eye.6701545","article-title":"Congenital disorders of the optic nerve: excavations and hypoplasia","volume":"18","author":"Dutton","year":"2004","journal-title":"Eye"},{"key":"B44","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1023\/a:1014498717741","article-title":"Rhegmatogenous retinal detachment in morning glory syndrome pathogenesis and treatment","volume":"24","author":"Ho","year":"2001","journal-title":"Int Ophthalmol"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1097\/ICB.0000000000001303.","article-title":"Management of retinal detachment associated with morning glory syndrome using human amniotic membrane","author":"Caporossi","year":"2022"},{"key":"B46","doi-asserted-by":"publisher","first-page":"e522","DOI":"10.1111\/aos.13516","article-title":"Transplantation of amniotic membrane for choroidal hole to treat suprachoroidal silicone oil migration","volume":"95","author":"Zhu","year":"2017","journal-title":"Acta Ophthalmol"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2023.1206577\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T07:04:01Z","timestamp":1696921441000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2023.1206577\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,10]]},"references-count":46,"alternative-id":["10.3389\/fmed.2023.1206577"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2023.1206577","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,10]]},"article-number":"1206577"}}