{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T19:12:42Z","timestamp":1789067562939,"version":"build-2803163510"},"reference-count":91,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T00:00:00Z","timestamp":1693180800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>Psoriasis is a chronic inflammatory skin disease with keratinocyte hyperproliferation and T cells as key mediators of lesional and systemic inflammatory changes. To date, no suitable differential biomarkers are available for the disease diagnosis. More recently, microRNAs have been identified as critical regulators of lesional and systemic immune changes in psoriasis with diagnostic potential. We have performed expression profiling of T cell-specific miRNAs in 38 plasma samples from psoriasis vulgaris patients and an equal number of age- and gender-matched healthy subjects. Our findings have identified a panel of five blood-based circulatory miRNAs with a significant change in their expression levels, comprising miR-215, miR-148a, miR-125b-5p, miR-223, and miR-142-3p, which can differentiate psoriasis vulgaris patients from healthy individuals. The receiver operating characteristic (ROC) curves for all five miRNAs individually and in combination exhibited a significant disease discriminatory area under the curve with an AUC of 0.762 and a <jats:italic>p<\/jats:italic> &amp;lt; 0.0001 for all the miRNAs together. Statistically, all five miRNAs in combination depicted the best-fit model in relation to disease severity (PASI) compared with individual miRNAs, with the highest R<jats:sup>2<\/jats:sup> value of 0.94 and the lowest AIC score of 131.8. Each of the miRNAs also exhibited a significant association with at least one of the other miRNAs in the panel. Importantly, the five miRNAs in the panel regulate one or more immune-inflammation pathways based on target prediction, pathway network analysis, and validated roles in the literature. The miRNA panel provides a rationalized combination of biomarkers that can be tested further on an expanded cohort of patients for their diagnostic value.<\/jats:p>","DOI":"10.3389\/fmed.2023.1207993","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T08:24:36Z","timestamp":1693211076000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["A panel of blood-based circulatory miRNAs with diagnostic potential in patients with psoriasis"],"prefix":"10.3389","volume":"10","author":[{"given":"Priyanka","family":"Madaan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uttam","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nipanshi","family":"Tyagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balvinder Kaur","family":"Brar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivani","family":"Bansal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemant Rituraj","family":"Kushwaha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harmanpreet Singh","family":"Kapoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aklank","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manju","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,8,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1056\/NEJMra0804595","article-title":"Psoriasis","volume":"361","author":"Nestle","year":"2009","journal-title":"N Engl J Med."},{"key":"B2","doi-asserted-by":"publisher","first-page":"e4","DOI":"10.1111\/bjd.15610","article-title":"The global state of psoriasis disease epidemiology: a workshop report","volume":"177","author":"Griffiths","year":"2017","journal-title":"Br J Dermatol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1038\/cmi.2012.15","article-title":"New insights of T cells in the pathogenesis of psoriasis","volume":"9","author":"Cai","year":"2012","journal-title":"Cell Mol Immunol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"7692024","DOI":"10.1155\/2016\/7692024","article-title":"Helper cell subsets in clinical manifestations of psoriasis","volume":"2016","author":"Diani","year":"2016","journal-title":"J Immunol Res."},{"key":"B5","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.autrev.2014.01.008","article-title":"Diagnosis and classification of psoriasis","volume":"13","author":"Raychaudhuri","year":"2014","journal-title":"Autoimmun Rev."},{"key":"B6","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1371\/journal.pone.0000610","article-title":"MicroRNAs: novel regulators involved in the pathogenesis of psoriasis?","volume":"2","author":"Sonkoly","year":"2007","journal-title":"PLoS ONE."},{"key":"B7","doi-asserted-by":"publisher","first-page":"4025","DOI":"10.1093\/hmg\/ddr331","article-title":"Deep sequencing of small RNAs from human skin reveals major alterations in the psoriasis miRNAome","volume":"20","author":"Joyce","year":"2011","journal-title":"Hum Mol Genet."},{"key":"B8","doi-asserted-by":"publisher","first-page":"a015354","DOI":"10.1101\/cshperspect.a015354","article-title":"Psoriasis","volume":"4","author":"Di Meglio","year":"2014","journal-title":"Cold Spring Harb Perspect Med"},{"key":"B9","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1152\/physiolgenomics.00157.2013","article-title":"MicroRNAs in normal and psoriatic skin","volume":"46","author":"Xia","year":"2014","journal-title":"Physiol Genomics."},{"key":"B10","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1097\/MD.0000000000002030","article-title":"An exploration of the role of microRNAs in psoriasis: a systematic review of the literature","volume":"94","author":"Huang RY Li","year":"2015","journal-title":"Medicine (Baltimore)."},{"key":"B11","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1111\/exd.13520","article-title":"The contribution of feedback loops between miRNAs, cytokines and growth factors to the pathogenesis of psoriasis","volume":"27","author":"Masalha","year":"2018","journal-title":"Exp Dermatol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1038\/nri3494","article-title":"MicroRNA-mediated regulation of T helper cell differentiation and plasticity","volume":"13","author":"Baumjohann","year":"2013","journal-title":"Nat Rev Immunol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"8","DOI":"10.3389\/fgene.2013.00008","article-title":"Role of miRNAs in CD4 T cell plasticity during inflammation and tolerance","volume":"4","author":"Sethi","year":"2013","journal-title":"Front Genet."},{"key":"B14","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1186\/1471-2164-14-184","article-title":"Differential miRNA expression profiles in proliferating or differentiated keratinocytes in response to gamma irradiation","volume":"14","author":"Joly-Tonetti","year":"2013","journal-title":"BMC Genomics."},{"key":"B15","doi-asserted-by":"publisher","first-page":"e66709","DOI":"10.1371\/journal.pone.0066709","article-title":"miRNA signature of mouse helper T cell hyper-proliferation","volume":"8","author":"Sommers","year":"2013","journal-title":"PLoS ONE."},{"key":"B16","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3390\/ijms21165781","article-title":"The role of microRNAs in epidermal barrier","volume":"21","author":"Lee","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B17","doi-asserted-by":"publisher","first-page":"17442","DOI":"10.1074\/jbc.M110.107821","article-title":"Secretory mechanisms and intercellular transfer of microRNAs in living cells","volume":"285","author":"Kosaka","year":"2010","journal-title":"J Biol Chem."},{"key":"B18","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.cell.2019.02.018","article-title":"exRNA atlas analysis reveals distinct extracellular RNA cargo types and their carriers present across human biofluids","volume":"177","author":"Murillo","year":"2019","journal-title":"Cell"},{"key":"B19","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.jdermsci.2014.01.005","article-title":"Analysis of expression pattern of serum microRNA levels in patients with psoriasis","volume":"74","author":"Koga","year":"2014","journal-title":"J Dermatol Sci."},{"key":"B20","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.jdermsci.2014.05.005","article-title":"MicroRNA-223 and miR-143 are important systemic biomarkers for disease activity in psoriasis","volume":"75","author":"Lovendorf","year":"2014","journal-title":"J Dermatol Sci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1111\/1346-8138.12460","article-title":"miR-424 levels in hair shaft are increased in psoriatic patients","volume":"41","author":"Tsuru","year":"2014","journal-title":"J Dermatol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1561278","DOI":"10.1155\/2020\/1561278","article-title":"Plasma microRNA expression profiles in psoriasis","volume":"2020","author":"Xiao","year":"2020","journal-title":"J Immunol Res."},{"key":"B23","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1684\/ejd.2013.2148","article-title":"Serum and skin levels of miR-369-3p in patients with psoriasis and their correlation with disease severity","volume":"23","author":"Guo","year":"2013","journal-title":"Eur J Dermatol: EJD."},{"key":"B24","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1684\/ejd.2011.1600","article-title":"Increased serum levels of miR-1266 in patients with psoriasis vulgaris","volume":"22","author":"Ichihara","year":"2012","journal-title":"Eur J Dermatol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"102472","DOI":"10.1016\/j.jaut.2020.102472","article-title":"Utility of circulating serum miRNA profiles to evaluate the potential risk and severity of immune-mediated inflammatory disorders","volume":"111","author":"Mart\u00ednez-Hern\u00e1ndez","year":"2020","journal-title":"J Autoimmun."},{"key":"B26","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1111\/bjd.12381","article-title":"Changes in the level of serum microRNAs in patients with psoriasis after antitumour necrosis factor-alpha therapy","volume":"169","author":"Pivarcsi","year":"2013","journal-title":"Br J Dermatol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.adengl.2014.04.003","article-title":"Abnormal levels of expression of plasma microRNA-33 in patients with psoriasis","volume":"105","author":"Garcia-Rodriguez","year":"2014","journal-title":"Actas Dermosifiliogr."},{"key":"B28","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1615\/CritRevImmunol.2013006858","article-title":"MicroRNA regulation of T-lymphocyte immunity: modulation of molecular networks responsible for T cell activation, differentiation, and development","volume":"33","author":"Podshivalova","year":"2013","journal-title":"Crit Rev Immunol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"2148","DOI":"10.3389\/fimmu.2018.02148","article-title":"Control of immunoregulatory molecules by miRNAs in T cell activation","volume":"9","author":"Rodriguez-Galan","year":"2018","journal-title":"Front Immunol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1038\/ni.2057","article-title":"Distinct microRNA signatures in human lymphocyte subsets and enforcement of the naive state in CD4+ T cells by the microRNA miR-125b","volume":"12","author":"Rossi","year":"2011","journal-title":"Nat Immunol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1093\/intimm\/dxt065","article-title":"MiR-568 inhibits the activation and function of CD4(+) T cells and Treg cells by targeting NFAT5","volume":"26","author":"Li","year":"2014","journal-title":"Int Immunol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/j.bbrc.2017.09.123","article-title":"MicroRNA-590 promotes pathogenic Th17 cell differentiation through targeting Tob1 and is associated with multiple sclerosis","volume":"493","author":"Liu","year":"2017","journal-title":"Biochem Biophys Res Commun."},{"key":"B33","doi-asserted-by":"publisher","first-page":"6648","DOI":"10.1182\/blood-2008-09-181156","article-title":"microRNA 184 regulates expression of NFAT1 in umbilical cord blood CD4+ T cells","volume":"113","author":"Weitzel","year":"2009","journal-title":"Blood."},{"key":"B34","doi-asserted-by":"publisher","first-page":"2584","DOI":"10.1016\/j.celrep.2017.08.060","article-title":"miR-150 regulates memory CD8 T cell differentiation via c-Myb","volume":"20","author":"Chen","year":"2017","journal-title":"Cell Rep."},{"key":"B35","doi-asserted-by":"publisher","first-page":"7053","DOI":"10.1182\/blood-2010-12-326629","article-title":"Modulation of microRNA expression in human T cell development: targeting of NOTCH3 by miR-150","volume":"117","author":"Ghisi","year":"2011","journal-title":"Blood."},{"key":"B36","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1111\/1346-8138.14338","article-title":"Asian consensus on assessment and management of mild to moderate plaque psoriasis with topical therapy","volume":"45","author":"Imafuku","year":"2018","journal-title":"J Dermatol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat Protoc."},{"key":"B38","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1111\/cas.14199","article-title":"Circulating microRNA-590-5p functions as a liquid biopsy marker in non-small cell lung cancer","volume":"111","author":"Khandelwal","year":"2020","journal-title":"Cancer Sci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1097\/JTO.0b013e3181ec173d","article-title":"Receiver operating characteristic curve in diagnostic test assessment","volume":"5","author":"Mandrekar","year":"2010","journal-title":"J Thorac Oncol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1890","DOI":"10.1159\/000430158","article-title":"Wnt\/\u03b2-catenin and Wnt5a\/Ca pathways regulate proliferation and apoptosis of keratinocytes in psoriasis lesions","volume":"36","author":"Zhang","year":"2015","journal-title":"Cell Physiol Biochem."},{"key":"B41","doi-asserted-by":"publisher","first-page":"2193","DOI":"10.4049\/jimmunol.1800633","article-title":"The role of WNT signaling in mature T cells: T cell factor is coming home","volume":"201","author":"van Loosdregt","year":"2018","journal-title":"J Immunol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1515\/med-2018-0029","article-title":"Pathway involved in epidermal terminal differentiation of normal human epidermal keratinocytes","volume":"13","author":"Meng","year":"2018","journal-title":"Open Med. (Warsaw, Poland)."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1038\/jid.2011.55","article-title":"MiR-125b, a microRNA downregulated in psoriasis, modulates keratinocyte proliferation by targeting FGFR2","volume":"131","author":"Xu","year":"2011","journal-title":"J Invest Dermatol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/S0952-7915(00)00224-7","article-title":"MAP-kinase signaling pathways in T cells","volume":"13","author":"Rinc\u00f3n","year":"2001","journal-title":"Curr Opin Immunol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/jid.2009.252","article-title":"role for TGFbeta signaling in the pathogenesis of psoriasis","volume":"130","author":"Han","year":"2010","journal-title":"J Invest Dermatol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"3973","DOI":"10.4049\/jimmunol.1301843","article-title":"TGF-\u03b2: guardian of T cell function","volume":"191","author":"Oh","year":"2013","journal-title":"J Immunol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"371","DOI":"10.2340\/00015555-1737","article-title":"Phosphoinositide-3 kinase\/protein kinase-B\/mammalian target of rapamycin pathway in psoriasis pathogenesis. A potential therapeutic target?","volume":"94","author":"Huang","year":"2014","journal-title":"Acta Dermato-Venereologica."},{"key":"B48","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.lfs.2019.05.045","article-title":"MiR-223 regulates proliferation and apoptosis of IL-22-stimulated HaCat human keratinocyte cell lines via the PTEN\/Akt pathway","volume":"230","author":"Wang","year":"2019","journal-title":"Life Sci."},{"key":"B49","doi-asserted-by":"publisher","first-page":"245","DOI":"10.3389\/fimmu.2012.00245","article-title":"The role of the PI3K signaling pathway in CD4(+) T cell differentiation and function","volume":"3","author":"Han","year":"2012","journal-title":"Front Immunol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"2786","DOI":"10.3389\/fimmu.2018.02786","article-title":"Epidermal mTORC1 signaling contributes to the pathogenesis of psoriasis and could serve as a therapeutic target","volume":"9","author":"Buerger","year":"2018","journal-title":"Front Immunol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.it.2014.11.005","article-title":"Regulation of T cells by mTOR: the known knowns and the known unknowns","volume":"36","author":"Pollizzi","year":"2015","journal-title":"Trends Immunol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1111\/exd.14188","article-title":"MicroRNA-215-5p inhibits the proliferation of keratinocytes and alleviates psoriasis-like inflammation by negatively regulating DYRK1A and its downstream signalling pathways","volume":"30","author":"Liu","year":"2021","journal-title":"Exp Dermatol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"101573","DOI":"10.1016\/j.mcp.2020.101573","article-title":"Repression of miR-142-3p alleviates psoriasis-like inflammation by repressing proliferation and promoting apoptosis of keratinocytes via targeting Sema3A","volume":"52","author":"Zhang","year":"2020","journal-title":"Mol Cell Probes."},{"key":"B54","doi-asserted-by":"publisher","first-page":"5227","DOI":"10.3892\/mmr.2019.10187","article-title":"miR125bmediated regulation of cell proliferation through the Jagged1\/Notch signaling pathway by inhibiting BRD4 expression in psoriasis","volume":"19","author":"Pan","year":"2019","journal-title":"Mol Med Rep."},{"key":"B55","doi-asserted-by":"publisher","first-page":"190187","DOI":"10.1098\/rsob.190187","article-title":"Notch signalling in T cell homeostasis and differentiation","volume":"9","author":"Brandstadter","year":"2019","journal-title":"Open Biol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"8","DOI":"10.3390\/medicina57080754","article-title":"The role of chemokines in psoriasis-an overview","volume":"57","author":"Zdanowska","year":"2021","journal-title":"Medicina"},{"key":"B57","doi-asserted-by":"publisher","first-page":"155535","DOI":"10.1016\/j.cyto.2021.155535","article-title":"STAT3\/SH3PXD2A-AS1\/miR-125b\/STAT3 positive feedback loop affects psoriasis pathogenesis via regulating human keratinocyte proliferation","volume":"144","author":"Yang","year":"2021","journal-title":"Cytokine."},{"key":"B58","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1038\/s41577-018-0020-8","article-title":"Regulatory mechanisms in T cell receptor signalling","volume":"18","author":"Gaud","year":"2018","journal-title":"Nat Rev Immunol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1046\/j.1468-3083.2003.00720.x","article-title":"The role of T cells in psoriasis","volume":"17","author":"Prinz","year":"2003","journal-title":"JEADV."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1038\/nm.1995","article-title":"Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis","volume":"15","author":"Caruso","year":"2009","journal-title":"Nat Med."},{"key":"B61","doi-asserted-by":"publisher","first-page":"3501","DOI":"10.4049\/jimmunol.1301454","article-title":"IL-21-producing Th cells in immunity and autoimmunity","volume":"191","author":"Liu","year":"2013","journal-title":"J Immunol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"7780","DOI":"10.1038\/s41598-017-07853-x","article-title":"Identification of the novel 3\u2032 UTR sequences of human IL-21 mRNA as potential targets of miRNAs","volume":"7","author":"Enomoto","year":"2017","journal-title":"Sci Rep."},{"key":"B63","doi-asserted-by":"publisher","first-page":"409","DOI":"10.2147\/ITT.S240891","article-title":"The role of IL-17 cytokines in psoriasis","volume":"10","author":"Mosca","year":"2021","journal-title":"Immuno Targets Ther."},{"key":"B64","doi-asserted-by":"publisher","first-page":"e114647","DOI":"10.1371\/journal.pone.0114647","article-title":"IL-17\/miR-192\/IL-17Rs regulatory feedback loop facilitates multiple myeloma progression","volume":"9","author":"Sun","year":"2014","journal-title":"PLoS ONE."},{"key":"B65","doi-asserted-by":"publisher","first-page":"4817","DOI":"10.18632\/oncotarget.6736","article-title":"miR-215 promotes malignant progression of gastric cancer by targeting RUNX1","volume":"7","author":"Li","year":"2016","journal-title":"Oncotarget."},{"key":"B66","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1111\/bjd.18178","article-title":"Psoriatic epidermis is associated with upregulation of CDK2 and inhibition of CDK4 activity","volume":"182","author":"Henri","year":"2020","journal-title":"Br J Dermatol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"2825","DOI":"10.1172\/JCI78753","article-title":"Mature T cell responses are controlled by microRNA-142","volume":"125","author":"Sun","year":"2015","journal-title":"J Clin Invest."},{"key":"B68","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1159\/000018394","article-title":"Apoptosis in established and healing psoriasis","volume":"200","author":"Laporte","year":"2000","journal-title":"Dermatology."},{"key":"B69","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.canlet.2014.11.028","article-title":"Curcumin promotes apoptosis by activating the p53-miR-192-5p\/215-XIAP pathway in non-small cell lung cancer","volume":"357","author":"Ye","year":"2015","journal-title":"Cancer Lett."},{"key":"B70","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1089\/cbr.2019.3011","article-title":"MicroRNA-215 regulates the apoptosis of HCT116 colon cancer cells by inhibiting x-linked inhibitor of apoptosis protein","volume":"36","author":"Lu","year":"2021","journal-title":"Cancer Biother Radiopharm."},{"key":"B71","unstructured":""},{"key":"B72","unstructured":""},{"key":"B73","unstructured":""},{"key":"B74","unstructured":""},{"key":"B75","unstructured":""},{"key":"B76","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/nri3198","article-title":"Regulation and function of mTOR signalling in T cell fate decisions","volume":"12","author":"Chi","year":"2012","journal-title":"Nat Rev Immunol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.det.2014.09.002","article-title":"The immunopathogenesis of psoriasis","volume":"33","author":"Kim","year":"2015","journal-title":"Dermatol Clin."},{"key":"B78","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1038\/jid.2009.399","article-title":"Circulating Th17, Th22, and Th1 cells are increased in psoriasis","volume":"130","author":"Kagami","year":"2010","journal-title":"J Invest Dermatol."},{"key":"B79","first-page":"8978","article-title":"miR-215 controls proliferation, invasion, and apoptosis of human retinoblastoma cells by regulating RB1 expression","volume":"11","author":"Zhang","year":"2018","journal-title":"Int J Clin Exp Med."},{"key":"B80","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.3892\/ol.2015.3587","article-title":"miR-215 functions as a tumor suppressor and directly targets ZEB2 in human non-small cell lung cancer retraction in\/10","volume":"10","author":"Hou","year":"2015","journal-title":"Oncol Lett"},{"key":"B81","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1111\/j.1365-2133.2011.10497.x","article-title":"microRNA-mediated keratinocyte hyperproliferation in psoriasis vulgaris","volume":"165","author":"Ichihara","year":"2011","journal-title":"Br J Dermatol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1111\/imr.12055","article-title":"Role of microRNAs and long-non-coding RNAs in CD4+T cell differentiation","volume":"253","author":"Pagani","year":"2013","journal-title":"Immunol Rev."},{"key":"B83","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1002\/eji.201444633","article-title":"miR-148a is upregulated by Twist1 and T-bet and promotes Th1-cell survival by regulating the proapoptotic gene Bim","volume":"45","author":"Haftmann","year":"2015","journal-title":"Eur J Immunol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1172\/jci.insight.133721","article-title":"MicroRNA-148a facilitates inflammatory dendritic cell differentiation and autoimmunity by targeting MAFB","volume":"5","author":"Meng","year":"2020","journal-title":"JCI Insight"},{"key":"B85","doi-asserted-by":"publisher","first-page":"371","DOI":"10.22074\/cellj.2016.4565","article-title":"Upregulation of CD4(+) T cell derived MiR-223 in the relapsing phase of multiple sclerosis patients","volume":"18","author":"Hosseini","year":"2016","journal-title":"Cell J."},{"key":"B86","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1111\/cei.12374","article-title":"Increased miR-223 expression in T cells from patients with rheumatoid arthritis leads to decreased insulin-like growth factor-1-mediated interleukin-10 production","volume":"177","author":"Lu MC Yu","year":"2014","journal-title":"Clin Exp Immunol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1111\/imm.12611","article-title":"MicroRNA223 promotes pathogenic T cell development and autoimmune inflammation in central nervous system in mice","volume":"148","author":"Satoorian","year":"2016","journal-title":"Immunology."},{"key":"B88","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1111\/exd.12604","article-title":"Laser capture microdissection followed by next-generation sequencing identifies disease-related microRNAs in psoriatic skin that reflect systemic microRNA changes in psoriasis","volume":"24","author":"Lovendorf","year":"2015","journal-title":"Exp Dermatol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1111\/jdv.13861","article-title":"Increased expression of microRNA-155 in peripheral blood mononuclear cells from psoriasis patients is related to disease activity","volume":"31","author":"Garcia-Rodriguez","year":"2017","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"B90","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1038\/embor.2008.224","article-title":"miR-142-3p restricts cAMP production in CD4+CD25- T cells and CD4+CD25+ TREG cells by targeting AC9 mRNA","volume":"10","author":"Huang","year":"2009","journal-title":"EMBO Rep."},{"key":"B91","doi-asserted-by":"publisher","first-page":"172659","DOI":"10.1016\/j.ejphar.2019.172659","article-title":"MiR-125b-5p and miR-181b-5p inhibit keratinocyte proliferation in skin by targeting Akt3","volume":"862","author":"Zheng","year":"2019","journal-title":"Eur J Pharmacol."}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2023.1207993\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T08:24:41Z","timestamp":1693211081000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2023.1207993\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,28]]},"references-count":91,"alternative-id":["10.3389\/fmed.2023.1207993"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2023.1207993","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,28]]},"article-number":"1207993"}}