{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T08:10:31Z","timestamp":1793693431309,"version":"4.5.1"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T00:00:00Z","timestamp":1689638400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>This study aimed to explore the relationship between neuraxial labor analgesia and intrapartum fever and to demonstrate the influence of maternal fever on perinatal outcomes within 6 weeks after birth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a secondary analysis of a multicenter prospective cohort study that enrolled women with single- and full-term cephalic pregnancy in northern China. Intrapartum maternal fever was defined as the highest axillary temperature during labor \u226537.5\u00b0C. Data on baseline characteristics, maternal variables, and neonatal outcomes were all collected. The association between neuraxial labor analgesia and intrapartum maternal fever was analyzed with logistic regression models, and the cutoff point was identified by the receiver operating characteristic curve.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 577 parturients, 74 (12.8%) developed intrapartum fever. Neuraxial analgesia was associated with an increased risk of maternal intrapartum fever with or without adjusting for confounding factors (adjusted OR = 2.68; 95% CI: 1.32\u20135.47;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.007). Further analysis showed that neuraxial analgesia of &amp;lt;5 h did not increase the risk of intrapartum fever compared with no analgesia (OR = 1.52; 95% CI: 0.63\u20133.64;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.35), and longer neuraxial labor analgesia time (over 5 h) significantly increased the risk of fever (OR = 3.38; 95% CI: 1.63\u20137.01;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.001). Parturients with intrapartum fever suffered more maternal adverse outcomes compared with those without fever (\n                      <jats:italic>p<\/jats:italic>\n                      <jats:bold>&amp;lt;<\/jats:bold>\n                      0.001). Neonates of women with intrapartum fever had slightly higher rates of composite adverse neonatal outcomes compared with those without fever; however, the difference was not statistically significant (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.098).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In women with low-risk pregnancies, a longer time of neuraxial labor analgesia was associated with an increased risk of intrapartum maternal fever. Intrapartum fever was related to adverse maternal outcomes but did not significantly affect neonatal outcomes within 6 weeks after delivery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fmed.2023.1208570","type":"journal-article","created":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T04:17:55Z","timestamp":1689653875000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Effects of neuraxial labor analgesia on intrapartum maternal fever in full-term pregnancy and its influence on birth outcomes"],"prefix":"10.3389","volume":"10","author":[{"given":"Zhen","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Mei","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Hui","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,7,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1080\/14767058.2017.1317740","article-title":"Intrapartum fever and the risk for perinatal complications\u2014The effect of fever duration and positive cultures","volume":"31","author":"Ashwal","year":"2018","journal-title":"J Maternal-Fetal Neonatal Med J Eur Assoc Peri Med Fed Asia Oceania Perinatal Soc Int Soc Perinatal Obstet."},{"key":"B2","doi-asserted-by":"publisher","first-page":"5354","DOI":"10.1080\/14767058.2021.1879042","article-title":"The relationship between epidural analgesia and intrapartum maternal fever and the consequences for maternal and neonatal outcomes: a prospective observational study","volume":"35","author":"Zhao","year":"2022","journal-title":"J Maternal-Fetal Neonatal Med J Eur Assoc Peri Med Fed Asia Oceania Perinatal Soc Int Soc Perinatal Obstet."},{"key":"B3","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1016\/j.bja.2020.09.046","article-title":"Epidural analgesia, intrapartum hyperthermia, and neonatal brain injury: a systematic review and meta-analysis","volume":"126","author":"Morton","year":"2021","journal-title":"Br J Anaesth."},{"key":"B4","doi-asserted-by":"publisher","first-page":"49.e1","DOI":"10.1016\/j.ajog.2007.06.011","article-title":"The relationship between intrapartum maternal fever and neonatal acidosis as risk factors for neonatal encephalopathy","volume":"198","author":"Impey","year":"2008","journal-title":"Am J Obst Gynecol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1159\/000453611","article-title":"Risk factors for intrapartum fever in term gestations and associated maternal and neonatal sequelae","volume":"82","author":"Burgess","year":"2017","journal-title":"Gynecol Obstet Invest."},{"key":"B6","doi-asserted-by":"publisher","first-page":"2179383","DOI":"10.1080\/14767058.2023.2179383","article-title":"Perinatal outcomes and risk factors for epidural analgesia-associated intrapartum maternal fever: a retrospective study","volume":"36","author":"Wang","year":"2023","journal-title":"J Maternal-Fetal Neonatal Med J Eur Assoc Peri Med Fed Asia Oceania Perinatal Soc Int Soc Perinatal Obstet."},{"key":"B7","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1213\/ane.0000000000004576","article-title":"Epidural-related maternal fever: still a hot topic, but what are the burning issues?","volume":"130","author":"Sultan","year":"2020","journal-title":"Anesth Analg."},{"key":"B8","first-page":"38","article-title":"Advances in labor analgesia","volume":"69","author":"Beilin","year":"2002","journal-title":"Mt Sinai J Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1093\/bja\/aer218","article-title":"Jr","volume":"107","author":"de Orange","year":"2011","journal-title":"Br J Anaesth."},{"key":"B10","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1097\/ALN.0b013e31825a30ef","article-title":"What factors affect intrapartum maternal temperature? 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