{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T21:13:42Z","timestamp":1782422022255,"version":"3.54.5"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T00:00:00Z","timestamp":1694476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the safety, efficacy, patients\u2019 satisfaction and acceptability of Rexon-Eye electrotherapy in treating Asian severe dry eye disease (DED) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective parallel-arm pilot study recruiting 40 DED Chinese patients with &amp;gt;moderate recalcitrant DED (Contact Lens Research Unit [CCLRU] &amp;gt; grade 2). Subjects were randomized into 2 groups, undergoing four weekly treatment sessions each: group 1 received full treatment power; group 2 received control treatment (power 1 treatment). Non-invasive tear break-up time (NIBUT), cornea fluorescein staining graded via CCLRU and Schirmer\u2019s I test were compared pre- and 2 months post-treatment. The SPEED and QUEST questionnaires that evaluated subjective symptoms and treatment satisfaction, respectively, at baseline and 2 weeks post-treatment were carried out. Tear cytokine levels in both groups were examined at 2 weeks post-treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The amount of improvement in post-treatment corneal staining in the inferior corneal zone was significant in Group 1 (<jats:italic>p<\/jats:italic> = 0.038) but not in Group 2 (<jats:italic>p<\/jats:italic> = 0.832). Group 1 eyes with worse baseline staining (total score &amp;gt;9.8) had a significantly greater reduction of corneal staining than those with better baseline staining (\u221211.7 \u00b1 1.98 vs. \u22124.6 \u00b1 2.89, <jats:italic>p<\/jats:italic> &amp;lt; 0.001). There were no other significant differences in NIBUT, Schirmer\u2019s 1 and cornea fluorescein staining grading within or between the groups.: Group 1 (<jats:italic>n<\/jats:italic> = 24) had improved subjective dryness scores compared to Group 2 (<jats:italic>n<\/jats:italic> = 16) (SPEED score: 6.38 + 4.16 vs. 10.0 + 6.36, <jats:italic>p<\/jats:italic> = 0.04). No significant differences were seen in 11 tear cytokine levels at 2 weeks post-treatment between the 2 groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In Asian DED patients treated with Rexon-Eye, inferior cornea staining showed significant improvement compared to placebo, and eyes with greater cornea staining at baseline achieved a greater improvement in staining. There were no other significant improvements in NIBUT and Schirmer\u2019s 1. Rexon-Eye also improved subjective DED scores in 41.7% of eyes without any adverse effects.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2023.1209886","type":"journal-article","created":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T06:33:58Z","timestamp":1694586838000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Quantum molecular resonance electrotherapy (Rexon-Eye) for recalcitrant dry eye in an Asian population"],"prefix":"10.3389","volume":"10","author":[{"given":"Valencia Hui 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