{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:46:33Z","timestamp":1790304393864,"version":"4.1.0"},"reference-count":79,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T00:00:00Z","timestamp":1693440000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101084"],"award-info":[{"award-number":["82101084"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060173"],"award-info":[{"award-number":["82060173"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2021M69898"],"award-info":[{"award-number":["2021M69898"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:p>In humans, the lacrimal gland is located in the socket of the frontal bone above the outer orbital area. As an essential part of the eye surface, the gland is fixed to the orbital periosteum by connective tissue. The lacrimal gland passes through the outer tendon membrane, which divides the gland into larger orbital and minor eyelid glands. The lacrimal glands are the main contributors to tear film. They secrete electrolytes, proteins, and water to help nourish and protect the eye\u2019s surface. Furthermore, clinically, lacrimal glands are associated with a variety of inflammatory reactions and immune factors and are also vulnerable sites for tumors. Changes in tear gland morphology or secretory function affect tear film stability and tear secretion quality. Various technological devices have been developed and applied to lacrimal glands. This article systematically reviewed the clinical examination of the lacrimal gland to help inform personalized strategies for the diagnosis of lacrimal gland-related diseases.<\/jats:p>","DOI":"10.3389\/fmed.2023.1257209","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T16:06:24Z","timestamp":1693497984000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["Advances in clinical examination of lacrimal gland"],"prefix":"10.3389","volume":"10","author":[{"given":"Yuan","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huping","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangkun","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,8,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"7542929","DOI":"10.1155\/2016\/7542929","article-title":"Review: the lacrimal gland and its role in dry eye","volume":"2016","author":"Conrady","year":"2016","journal-title":"J Ophthalmol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1002\/dvdy.24551","article-title":"Lacrimal gland development: from signaling interactions to regenerative medicine","volume":"246","author":"Garg","year":"2017","journal-title":"Dev Dyn"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"159","DOI":"10.22608\/APO.201707","article-title":"An update on tumors of the lacrimal gland","volume":"6","author":"Andreasen","year":"2017","journal-title":"Asia Pac J Ophthalmol (Phila)"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1055\/s-0040-1722700","article-title":"Masses of the lacrimal gland: evaluation and treatment","volume":"82","author":"Kim","year":"2021","journal-title":"J Neurol Surg B Skull Base"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1016\/j.survophthal.2016.02.006","article-title":"Is the main lacrimal gland indispensable? 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