{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T23:22:51Z","timestamp":1770420171618,"version":"3.49.0"},"reference-count":14,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:00:00Z","timestamp":1695945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To examine primary open-angle glaucoma patients after undergoing combined cataract surgery with microhook ab interno trabeculotomy (\u03bcLOT-Phaco) or iStent inject W implantation (iStent-Phaco), and then evaluate the surgical outcomes after a minimum of 6\u2009months of follow-up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between October 2020 and July 2022, 39 \u03bcLOT-Phaco eyes and 55 iStent-Phaco eyes that underwent surgery were evaluated in this retrospective, multicenter comparative case series. Data that included preoperative and postoperative intraocular pressure (IOP), number of glaucoma medications, and occurrence of complications were collected from medical records and then examined. Surgical failure was defined as patients exhibiting <jats:italic>a<\/jats:italic>\u2009&amp;lt;\u200920% reduction in the preoperative IOP or an IOP\u2009&amp;gt;\u200918\u2009mmHg on two consecutive follow-up visits, or when patients were required to undergo reoperation. Success rates were determined based on a Kaplan\u2013Meier survival analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 3, 6 and 12\u2009months postoperatively, there was a significant postoperative reduction in the IOP (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001) and in the medications scores (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001) for both of the groups. In the \u03bcLOT-Phaco and iStent-Phaco groups, the probabilities of success at 6 and 12\u2009months were 55.3 and 45.5%, and 48.4 and 45.5% (<jats:italic>p<\/jats:italic>\u2009=\u20090.38; log-rank test), respectively. In the iStent-Phaco group, there was a significant decrease in the hyphema.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Comparable surgical outcomes occurred for both the \u03bcLOT and iStent inject W procedures.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2023.1266532","type":"journal-article","created":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T21:45:31Z","timestamp":1696110331000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Comparison of surgical outcomes between iStent inject W implantation and microhook ab interno trabeculotomy in combination with phacoemulsification in primary open-angle glaucoma patients"],"prefix":"10.3389","volume":"10","author":[{"given":"Hiromitsu","family":"Onoe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyuki","family":"Hirooka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Namiguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiro","family":"Mizoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Hosokawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Mochizuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Okada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kana","family":"Tokumo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Okumichi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiaki","family":"Kiuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,9,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1136\/bjo.2005.081224","article-title":"The number of people with glaucoma worldwide in 2010 and 2020","volume":"90","author":"Quigley","year":"2006","journal-title":"Br J Ophthalmol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1001\/archopht.126.8.1030","article-title":"Canadian Glaucoma study: 2. Risk factors for the progression of open-angle glaucoma","volume":"126","author":"Chauhan","year":"2008","journal-title":"Arch Ophthalmol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1001\/archopht.120.10.1268","article-title":"Reduction of intraocular pressure and glaucoma progression: results from the early manifest Glaucoma trial","volume":"120","author":"Heijl","year":"2002","journal-title":"Arch Ophthalmol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1001\/archopht.1963.00960040789022","article-title":"Experimental aqueous perfusion in enucleated human eyes","volume":"69","author":"Grant","year":"1963","journal-title":"Arch Ophthalmol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1001\/archopht.1993.01090120075025","article-title":"Surgical effects of trabeculotomy ab externo on adult eyes with primary open angle glaucoma and psedoexfoliaion syndrome","volume":"111","author":"Tanihara","year":"1993","journal-title":"Arch Ophthalmol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.3390\/jcm10102129","article-title":"Fellow-eye comparison between phaco-microhook ab-interno trabeculotomy and phaco-iStent trabecular micro^bypass stent","volume":"10","author":"Takayanagi","year":"2021","journal-title":"J Clin Med"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.18240\/ijo.2022.07.07","article-title":"Comparison of minimally invasive glaucoma surgery with trabecular micro-bypass stent and microhook ab interno trabeculotomy performed in conjunction with cataract surgery","volume":"15","author":"Tokuda","year":"2022","journal-title":"Int J Ophthalmol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"941","DOI":"10.18240\/ijo.2020.06.13","article-title":"Performance of glaucoma operations with Kahook dual blade or iStent combined with phacoemulsification in Japanese open angle glaucoma patients","volume":"13","author":"Iwasaki","year":"2020","journal-title":"Int J Ophthalmol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"558","DOI":"10.3390\/jcm12020558","article-title":"Comparison of mid-term outcomes between microhook ab interno trabeculotomy and goniotomy with the Kahook dual blade","volume":"12","author":"Okada","year":"2023","journal-title":"J Clin Med"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"3327","DOI":"10.3390\/jcm10153327","article-title":"Effects of preoperative intraocular pressure levels on surgical results of microhook ab interno trabeculotomy","volume":"10","author":"Tanito","year":"2021","journal-title":"J Clin Med"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s40123-019-0166-x","article-title":"Intermediate results of iStent or iStent inject implantation combined with cataract surgery in a real-world setting: a longitudinal retrospective study","volume":"8","author":"Guedes","year":"2019","journal-title":"Ophthalmol Ther"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1007\/s40123-019-00214-z","article-title":"One-year outcomes of second-generation trabecular micro-bypass stent (iStent inject) implantation with cataract surgery in different glaucoma subtypes and severities","volume":"8","author":"Salimi","year":"2019","journal-title":"Ophthalmol Ther"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"5541","DOI":"10.3390\/jcm10235541","article-title":"Comparison of postoperative hyphemas between microhook ab interno trabeculotomy and iStent using a new hyphema scoring system","volume":"10","author":"Ishida","year":"2021","journal-title":"J Clin Med"},{"key":"ref14","first-page":"15","article-title":"Consensus of definitions of success","volume-title":"Guidelines on design and reporting of surgical trials","author":"Heuer","year":"2009"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2023.1266532\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T21:45:35Z","timestamp":1696110335000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2023.1266532\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,29]]},"references-count":14,"alternative-id":["10.3389\/fmed.2023.1266532"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2023.1266532","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,29]]},"article-number":"1266532"}}