{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T05:17:43Z","timestamp":1792819063690,"version":"4.5.0"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T00:00:00Z","timestamp":1704672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To determine the 90 percent effective dose (ED90) of intrathecal sufentanil combined with ropivacaine 2.5\u2009mg for labor analgesia and observe its safety for parturients and neonates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a prospective, double-blind, biased coin up-and-down study. We injected a fixed 2.5\u2009mg ropivacaine combined with a designated dose of sufentanil intrathecally to observe the labor analgesic effect. The initial dose of sufentanil was assigned 1.0\u2009\u03bcg, and the remaining doses were assigned as per the biased coin up-and-down method. The criterion of successful response was defined as VAS\u2009\u2264\u200930\u2009mm after intrathecal injection at 10\u2009min. Safety was evaluated in terms of maternal and neonatal outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The ED90 dose of intrathecal sufentanil combined with ropivacaine 2.5\u2009mg (0.1%, 2.5\u2009mL) was 2.61\u2009\u03bcg (95% CI, 2.44 to 2.70\u2009\u03bcg) by isotonic regression. No respiratory depression, hypotension, or motor block was observed. Thirty-one (77.5%) parturients complained of pruritus, and 14 (35.0%) suffered nausea and vomiting. Three neonates reported a 1\u2009min Apgar score of \u22647, and none reported a 5\u2009min Apgar score of \u22647.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The ED90 of intrathecal sufentanil combined with ropivacaine 2.5\u2009mg for labor analgesia was 2.61\u2009\u03bcg. The dose is safe for parturients and neonates.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2023.1275605","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T05:47:57Z","timestamp":1704692877000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["A biased coin up-and-down sequential allocation trial to determine the ED90 of intrathecal sufentanil combined with ropivacaine 2.5\u2009mg for labor analgesia"],"prefix":"10.3389","volume":"10","author":[{"given":"Qiaoli","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqin","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,1,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e208","DOI":"10.1097\/AOG.0000000000003132","article-title":"ACOG 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Analg"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1093\/bja\/87.5.733","article-title":"Intrathecal ropivacaine or bupivacaine with fentanyl for labour","volume":"87","author":"Hughes","year":"2001","journal-title":"Br J Anaesth"},{"key":"ref19","first-page":"7001","article-title":"Effect of ropivacaine and sufentanil in epidural labor analgesia","volume-title":"Am J Transl Res","author":"Wen","year":"2021"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1007\/s00540-022-03061-8","article-title":"Versus conventional epidural analgesia for labor: a systematic review and meta-analysis of randomized controlled studies","volume":"36","author":"Yin","year":"2022","journal-title":"J Anesth"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1213\/ANE.0000000000001412","article-title":"The effect of combined spinal-epidural versus epidural analgesia in laboring women on nonreassuring fetal heart rate tracings: 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