{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:10:20Z","timestamp":1790035820374,"version":"4.0.1"},"reference-count":53,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:00:00Z","timestamp":1700697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Inverted Internal Limiting Membrane (ILM)-flap technique demonstrated its effectiveness, in terms of anatomical closure rate and visual acuity recovery for high myopic macular holes. We evaluated macular function after a successful inverted ILM-flap for macular holes in high myopic eyes (hMMH) using microperimetry to predict visual prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study on 23 eyes of 23 patients after surgical closure of hMMH, was performed. All patients underwent inverted ILM-flap and gas tamponade. Cataract surgery was performed in phakic eyes. Study outcomes including best-corrected visual acuity (BCVA), retinal sensitivity (RS) at central 12\u00b0, central retinal sensitivity (CRS) at central 4\u00b0 and mean deviation (MD), and fixation behavior as bivariate contour ellipse area (BCEA, degrees2) measured by microperimetry, were evaluated over 6\u2009months. A mixed-effects model was used to evaluate and compare the repeated measurements of outcomes between phakic and pseudophakic eyes. A regression model was performed to assess the relationship between BCVA at 6\u2009months and independent variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall mean BCVA improved from 0.98\u2009\u00b1\u20090.21 logMAR at baseline to 0.47\u2009\u00b1\u20090.31 logMAR at the last follow-up (<jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001). Over 6\u2009months, overall sensitivity measurements improved (RS, <jats:italic>p<\/jats:italic>\u2009=\u20090.001; CRS, <jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.0001; MD, <jats:italic>p<\/jats:italic>\u2009=\u20090.03), and the BCEA decreased in dimension, although not significantly (<jats:italic>p<\/jats:italic>\u2009\u2265\u20090.05). The mixed model revealed a significantly better effect of inverted ILM-flap combined with cataract surgery on BCVA and CRS in phakic eyes than inverted ILM-flap alone in pseudophakic ones. The regression model revealed a relationship of 6-month BCVA with pre-operative BCVA (<jats:italic>\u03b2<\/jats:italic>\u2009=\u20090.60, <jats:italic>p<\/jats:italic>\u2009=\u20090.02) and RS (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22120.03, <jats:italic>p<\/jats:italic>\u2009=\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The inverted ILM-flap technique significantly improved visual acuity and retinal sensitivity after the hMMH closure, particularly when combined with cataract extraction. Pre-operative visual acuity and retinal sensitivity at central 12\u00b0 may predict post-surgical visual acuity.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2023.1276502","type":"journal-article","created":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T10:13:01Z","timestamp":1700820781000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Microperimetric evaluation and predictive factors of visual recovery after successful inverted internal limiting membrane-flap technique for macular hole in high myopic eyes"],"prefix":"10.3389","volume":"10","author":[{"given":"Alessandra","family":"Sborgia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Boscia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Niro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Landini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Pastore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Albano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Piepoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Donghia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Dore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Viggiano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Buonamassa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Di Pardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Molfetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Eye Clinic Research Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Coassin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Dell\u2019Omo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Boscia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Alessio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giancarlo","family":"Sborgia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,11,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1136\/bjo.86.11.1269","article-title":"Macular hole and myopic refraction","volume":"86","author":"Kobayashi","year":"2002","journal-title":"Br J Ophthalmol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1097\/IAE.0b013e318255062c","article-title":"Macular vitreoretinal interface abnormalities in highly myopic eyes with posterior staphyloma","volume":"32","author":"Ripandelli","year":"2012","journal-title":"Retina"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1007\/s00417-015-2986-2","article-title":"Vitreo-retinal relationship and post-operative outcome of macular hole repair in eyes with high myopia","volume":"254","author":"Wu","year":"2016","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1136\/bjo.2011.203232","article-title":"Retinoschisis: a predictive factor in vitrectomy for macular holes without retinal detachment in highly myopic eyes","volume":"96","author":"Jo","year":"2012","journal-title":"Br J Ophthalmol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.1016\/j.ophtha.2005.06.028","article-title":"Prevalence of asymptomatic macular holes in highly myopic eyes","volume":"112","author":"Copp\u00e9","year":"2005","journal-title":"Ophthalmology"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/3230695","article-title":"Macular hole in myopic eyes: a narrative review of the current surgical techniques","volume":"2019","author":"De Giacinto","year":"2019","journal-title":"J Ophthalmol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1136\/bjophthalmol-2018-313311","article-title":"Foveal microstructure and visual outcomes of myopic macular hole surgery with or without the inverted internal limiting membrane flap technique","volume":"103","author":"Hu","year":"2019","journal-title":"Br J Ophthalmol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1097\/IAE.0000000000002368","article-title":"Anatomical and visual outcomes of inverted internal limiting membrane flap technique versus internal limiting membrane peeling in myopic macular hole without retinal detachment: a preliminary retrospective study","volume":"40","author":"Bov\u00e9","year":"2020","journal-title":"Retina"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.1097\/IAE.0000000000001446","article-title":"Inverted internal limiting membrane flap technique versus complete internal limiting membrane removal in myopic macular hole surgery: a comparative study","volume":"37","author":"Mete","year":"2017","journal-title":"Retina"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1016\/j.ophtha.2014.02.005","article-title":"Low-luminance visual acuity and microperimetry in age-related macular degeneration","volume":"121","author":"Wu","year":"2014","journal-title":"Ophthalmology"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1167\/iovs.63.11.13","article-title":"Association of Retinal Sensitivity with Optical Coherence Tomography Microstructure in highly myopic patients","volume":"63","author":"Park","year":"2022","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref12","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-540-33672-3_1","article-title":"Microperimetry in macular disease","volume-title":"Medical Retina. Essentials in Ophthalmology","author":"Rohrschneider","year":"2007"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1097\/ICB.0000000000000465","article-title":"SD-OCT and microperimetric correlated changes in progressive x-linked retinoschisis after vitrectomy: a case report","volume":"12","author":"Sborgia","year":"2018","journal-title":"Retinal cases & brief reports"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1097\/ICB.0000000000000731","article-title":"Inverted internal limiting membrane-flap technique for optic disk pit maculopathy: morphologic and functional analysis","volume":"15","author":"Sborgia","year":"2021","journal-title":"Retinal cases & brief reports"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1186\/s12886-023-03056-3","article-title":"Microperimetric evaluation for different methods of epiretinal membrane surgery","volume":"23","author":"Nam","year":"2023","journal-title":"BMC Ophthalmol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s40942-019-0195-6","article-title":"Inverted internal limiting membrane-flap technique for large macular hole: a microperimetric study","volume":"5","author":"Sborgia","year":"2019","journal-title":"Int J Retina Vitr"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1186\/s12886-015-0098-8","article-title":"Postoperative anatomical and functional outcomes of different stages of high myopia macular hole","volume":"15","author":"Shao","year":"2015","journal-title":"BMC Ophthalmol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.4103\/ijo.IJO_1119_17","article-title":"Retrospective study of changes in ocular coherence tomography characteristics after failed macular hole surgery and outcomes of fluid-gas exchange for persistent macular hole","volume":"66","author":"Vishal","year":"2018","journal-title":"Indian J Ophthalmol"},{"key":"ref19","first-page":"229","article-title":"Technical insights in the interpretation of automatic microperimetry","volume-title":"Perimetry and the fundus: An introduction to Microperimetry","author":"Convento","year":"2007"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1163\/187847611X620955","article-title":"Quantifying eye stability during a fixation task: a review of definitions and methods","volume":"25","author":"Castet","year":"2012","journal-title":"Seeing Perceiving"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1038\/s41433-019-0490-3","article-title":"Morphologic and functional outcomes of different optical coherence tomography patterns of myopic foveoschisis after vitrectomy and inner limiting membrane peeling","volume":"33","author":"Sborgia","year":"2019","journal-title":"Eye (Lond)"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1007\/s00417-021-05082-7","article-title":"Inverted internal limiting membrane flap technique in eyes with large idiopathic full-thickness macular hole: long-term functional and morphological outcomes","volume":"259","author":"Bleidi\u00dfel","year":"2021","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1097\/IAE.0b013e318242b81a","article-title":"Morphologic and functional evaluation before and after successful macular hole surgery using spectral-domain optical coherence tomography combined with microperimetry","volume":"32","author":"Chen","year":"2012","journal-title":"Retina"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"15832","DOI":"10.1038\/s41598-020-72774-1","article-title":"Inverted ILM-flap techniques variants for macular hole surgery: randomized clinical trial to compare retinal sensitivity and fixation stability","volume":"10","author":"Cacciamani","year":"2020","journal-title":"Sci Rep"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/j.survophthal.2021.02.010","article-title":"Inverted internal limiting membrane flap technique for myopic macular hole: a meta-analysis","volume":"66","author":"Chatziralli","year":"2021","journal-title":"Surv Ophthalmol"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"4847","DOI":"10.1167\/iovs.17-21756","article-title":"The role of inverted internal limiting membrane flap in macular hole closure","volume":"58","author":"Shiode","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000343701","article-title":"Macular hole surgery in a patient who cannot maintain facedown positioning","volume":"4","author":"Michalewska","year":"2013","journal-title":"Case Rep Ophthalmol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"e324","DOI":"10.1111\/aos.14575","article-title":"Factors predicting normal visual acuity following anatomically successful macular hole surgery","volume":"99","author":"Fallico","year":"2021","journal-title":"Acta Ophthalmol"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s00417-013-2555-5","article-title":"Anatomical and visual outcomes in high myopic macular hole (HM-MH) without retinal detachment: a review","volume":"252","author":"Alkabes","year":"2014","journal-title":"Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"4258","DOI":"10.1038\/s41598-022-08277-y","article-title":"Inverted internal limiting membrane flap technique for retinal detachment due to macular holes in high myopia with axial length\u2009\u2265\u200930 mm","volume":"12","author":"Xu","year":"2022","journal-title":"Sci Rep"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.ajo.2016.03.002","article-title":"Inverted internal limiting membrane insertion for macular hole\u2013associated retinal detachment in high myopia","volume":"165","author":"Theodossiadis","year":"2016","journal-title":"Am J Ophthalmol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1097\/IAE.0000000000001010","article-title":"Inverted internal limiting membrane flap technique for macular holes in high myopia with axial length \u226530 mm","volume":"36","author":"Ole\u00f1ik","year":"2016","journal-title":"Retina"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"2444","DOI":"10.1097\/IAE.0000000000000252","article-title":"Foveal microstructure in macular holes surgically closed by inverted internal limiting membrane flap technique","volume":"34","author":"Hayashi","year":"2014","journal-title":"Retina"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"e222","DOI":"10.1111\/j.1755-3768.2010.01898.x","article-title":"Retinal sensitivity and fixation changes 1 year after triamcinolone acetonide assisted internal limiting membrane peeling for macular hole surgery: a MP-1 microperimetric study","volume":"88","author":"Ozdemir","year":"2010","journal-title":"Acta Ophthalmol"},{"key":"ref35","first-page":"15","article-title":"Normal values of retinal sensitivity determined by macular integrity assessment","volume":"118","author":"Fujiwara","year":"2014","journal-title":"Nippon Ganka Gakkai Zasshi"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1111\/opo.12304","article-title":"Central perimetric sensitivity estimates are directly influenced by the fixation target","volume":"36","author":"Denniss","year":"2016","journal-title":"Ophthalmic Physiol Opt"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1097\/IAE.0b013e3182019be2","article-title":"Normative data set identifying properties of the macula across age groups: integration of visual function and retinal structure with microperimetry and spectral-domain optical coherence tomography","volume":"31","author":"Sabates","year":"2011","journal-title":"Retina"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"3464","DOI":"10.1167\/iovs.08-2926","article-title":"Test\u2013retest variability of Microperimetry using the Nidek MP1 in patients with macular disease","volume":"50","author":"Chen","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"273","DOI":"10.4103\/tjo.tjo_90_20","article-title":"Changes in retinal sensitivity following inverted internal limiting membrane flap technique for large macular holes","volume":"11","author":"Huang","year":"2021","journal-title":"Taiwan J Ophthalmol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1159\/000507450","article-title":"Effect of cataract extraction on retinal sensitivity measurements","volume":"64","author":"Palkovits","year":"2021","journal-title":"Ophthalmic Res"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1097\/IAE.0b013e3182437e86","article-title":"Swelling of the arcuate nerve fiber layer after internal limiting membrane peeling","volume":"32","author":"Clark","year":"2012","journal-title":"Retina"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1167\/iovs.08-2342","article-title":"Fixation stability, fixation location, and visual acuity after successful macular hole surgery","volume":"50","author":"Tarita-Nistor","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1186\/s12886-021-02164-2","article-title":"Frequently assessed and used prognostic factors for outcome after macular hole surgery: which is better?","volume":"21","author":"Roth","year":"2021","journal-title":"BMC Ophthalmol"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1016\/j.oret.2018.04.022","article-title":"The visual outcomes of macular hole surgery: a registry-based study by the Australian and new Zealand Society of Retinal Specialists","volume":"2","author":"Essex","year":"2018","journal-title":"Ophthalmol Retin"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1038\/s41433-020-0844-x","article-title":"Factors affecting anatomical and visual outcome after macular hole surgery: findings from a large prospective UK cohort","volume":"35","author":"Steel","year":"2021","journal-title":"Eye"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1136\/bjo.86.4.390","article-title":"Macular hole size as a prognostic factor in macular hole surgery","volume":"86","author":"Ullrich","year":"2002","journal-title":"Br J Ophthalmol"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1136\/bjo.85.1.96","article-title":"Predicting visual outcome after macular hole surgery using scanning laser ophthalmoscope microperimetry","volume":"85","author":"Amari","year":"2001","journal-title":"Br J Ophthalmol"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1097\/IAE.0000000000003642","article-title":"Comparison of air versus perfluoropropane intraocular tamponade combined with vitrectomy for the treatment of macular hole in high myopia","volume":"43","author":"Zhang","year":"2023","journal-title":"Retina"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1097\/IAE.0000000000001992","article-title":"Preoperative factors influencing visual recovery after vitrectomy for myopic foveoschisis","volume":"39","author":"Lehmann","year":"2019","journal-title":"Retina (Philadelphia, Pa)"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2022\/9293347","article-title":"Factors affecting visual prognosis of myopic Foveoschisis after macular buckling","volume":"2022","author":"Zhao","year":"2022","journal-title":"J Ophthalmol"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.1007\/s10792-018-1032-x","article-title":"MP-3 measurement of retinal sensitivity in macular hole area and its predictive value on visual prognosis","volume":"39","author":"Wang","year":"2019","journal-title":"Int Ophthalmol"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"779602","DOI":"10.3389\/fmed.2021.779602","article-title":"Ellipsoid zone and external limiting membrane-related parameters on spectral domain-optical coherence tomography and their relationships with visual prognosis after successful macular hole surgery","volume":"8","author":"Yang","year":"2021","journal-title":"Front Med"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1186\/s12886-023-03006-z","article-title":"Microstructural and microperimetric comparison of internal lim-iting membrane peeling and insertion in large idiopathic macular hole","volume":"23","author":"Liu","year":"2023","journal-title":"BMC Ophthalmol"}],"container-title":["Frontiers in Medicine"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2023.1276502\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,24]],"date-time":"2023-11-24T10:13:08Z","timestamp":1700820788000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fmed.2023.1276502\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,23]]},"references-count":53,"alternative-id":["10.3389\/fmed.2023.1276502"],"URL":"https:\/\/doi.org\/10.3389\/fmed.2023.1276502","relation":{},"ISSN":["2296-858X"],"issn-type":[{"value":"2296-858X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,23]]},"article-number":"1276502"}}