{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:06:05Z","timestamp":1753891565619,"version":"3.41.2"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T00:00:00Z","timestamp":1704672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Med."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The impact of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on patients with bronchiectasis in terms of symptoms, self-management and medical resource utilization was unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To describe the impact of infection by SARS-CoV-2 on fluctuation of symptoms, self-management and medical resource utilization of patients with bronchiectasis during the pandemic of COVID-19.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a single-center cross-sectional questionnaire study performed in Peking University Third Hospital. An online questionnaire investigation addressing the impact of SARS-CoV-2 infection on respiratory symptoms, self-management and medical resource utilization was conducted among patients with bronchiectasis during the COVID-19 surge in December 2022 in Beijing, China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five hundred patients with bronchiectasis, with 285 (57%) females, and a mean (<jats:inline-formula><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mo>\u00b1<\/mml:mo><mml:mi>S<\/mml:mi><mml:mi>D<\/mml:mi><\/mml:math><\/jats:inline-formula>) age of 57.9 <jats:inline-formula><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mo>\u00b1<\/mml:mo><\/mml:math><\/jats:inline-formula> 15.1\u2009years, completed the telephone questionnaire. The reported prevalence of COVID-19 was 81.2% (406\/500). Of the 406 COVID-19 patients, 89.2% experienced fever lasting mostly for no more than 3\u2009days, 70.6 and 61.8% reported exacerbated cough and sputum production respectively, and 17.7% reported worsened dyspnea. Notable 37.4% of the patients with COVID-19 experienced symptoms consistent with the definition of an acute exacerbation of bronchiectasis. However, 76.6% (311\/406) of the infected patients did not seek medical care but managed at home. Of the patients who visited hospitals, 26.3% (25\/95) needed hospitalization and 2.1% (2\/95) needed ICU admission. Multi-factors logistic regression analysis showed that younger age (<jats:italic>p<\/jats:italic> =\u20090.012) and not using a bronchodilator agent(<jats:italic>p<\/jats:italic> =\u20090.022) were independently associated with SARS-CoV-2 infection, while a history of exacerbation of bronchiectasis in the past year (<jats:italic>p<\/jats:italic> =\u20090.006) and daily use of expectorants (<jats:italic>p<\/jats:italic> =\u20090.002) were associated with emergency visit and\/or hospitalization for patients with bronchiectasis after SARS-CoV-2 infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>During the COVID-19 surge, the infection rate of SARS-CoV-2 in patients with bronchiectasis was high, and most of the patients experienced new-onset or exacerbated respiratory symptoms, but only a minority needed medical visits. Our survey results further underscore the importance of patients\u2019 disease awareness and self-management skills during a pandemic like COVID-19.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fmed.2023.1276763","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T05:46:50Z","timestamp":1704692810000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Symptoms and medical resource utilization of patients with bronchiectasis after SARS-CoV-2 infection"],"prefix":"10.3389","volume":"10","author":[{"given":"Jun","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqi","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongchang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,1,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1186\/s12931-022-02023-8","article-title":"Increasing prevalence and burden of bronchiectasis in urban Chineseadults, 2013-2017: a nationwide population-based cohort study","volume":"23","author":"Feng","year":"2022","journal-title":"Respir Res"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1002\/jcph.1878","article-title":"Pharmacological predictors of morbidity and mortality in COVID-19","volume":"61","author":"Oddy","year":"2021","journal-title":"J Clin Pharmacol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"102007","DOI":"10.1016\/j.pupt.2021.102007","article-title":"Inhaled bronchodilators use and clinical course of adult inpatients with Covid-19 pneumonia in Spain: a retrospective cohort study","volume":"69","author":"Villama\u00f1\u00e1n","year":"2021","journal-title":"Pulm Pharmacol Ther"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1038\/s41586-020-2521-4","article-title":"Factors associated with COVID-19-related death using OpenSAFELY","volume":"584","author":"Williamson","year":"2020","journal-title":"Nature"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1164\/rccm.202008-3266OC","article-title":"Asthma in adult patients with COVID-19. 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